High efficiency particulate air cleaner intervention to reduce respiratory virus exposure in elementary schools
High efficiency particulate air cleaner intervention to reduce respiratory virus exposure in elementary schools
批准号:
10722583
负责人:
Peggy Sue Lai
金额:
$27.49万
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-07-10 至 2025-06-30
关键词:
AdenovirusesAdherenceAirAllergensAsthmaBehaviorCOVID-19 outbreakCOVID-19 pandemicCOVID-19 patientChildCoronavirusDataDetectionDisinfectantsDoseEnterovirusEnvironmentExposure toFatigueFutureGoalsHandwashingHomeHouseholdHumanHumidityIndividualIndoor environmentInfectionInfection ControlInfluenza A virusInfrastructureIntentionInterventionIntervention StudiesIntervention TrialMasksMeaslesMetapneumovirusMissionMolecularMorbillivirusMumps virusNatureNoseParainfluenzaParticulatePlacebo ControlPredictive FactorPublic HealthPublishingRandomizedRandomized, Controlled TrialsResearchRespiratory syncytial virusRhinovirusRiskRubella virusSARS coronavirusSamplingSchoolsSourceStudentsStudy modelsSurfaceSurveysSymptomsTemperatureTestingUnited States National Institutes of HealthVaccinesViralViral Load resultViral Respiratory Tract InfectionVirusVirus Diseasesair samplingasthma exacerbationasthmaticbuilt environmentcohortdigitaldisease transmissionefficacy evaluationefficacy testingelementary schoolenvironmental interventionevidence basehigh efficiency particulate air filterinfluenzavirusinner cityinnovationmeterpandemic diseasepandemic influenzaportabilitypost-COVID-19protective behaviorpublic health interventionrandomized placebo controlled trialrandomized trialrecruitrespiratory infection virusrespiratory virusschool environmentschool reopeningscreeningsecondary analysistransmission processventilationviral detection
中文摘要
项目总结/文摘
英文摘要
PROJECT SUMMARY/ABSTRACT
There is a fundamental gap in understanding the extent to which the school environment contributes to
respiratory virus exposure, and less is known about effective environmental interventions to reduce exposure.
Our long-term goal is to create healthy indoor school environments for children. The overall objective of this
application is to identify environmental predictors of and potential interventions influencing respiratory virus
exposure in elementary schools. We will extend the robust infrastructure of the School Inner-City Asthma
Intervention Study (SICAS-2, ClinicalTrials.gov NCT02291302), a five-year randomized controlled trial
conducted by our group of a placebo-controlled classroom high efficiency particulate air (HEPA) cleaner
intervention to continue cohort recruitment in the post-COVID-19 pandemic period. We will test our central
hypothesis that modifiable built environment factors influence airborne respiratory virus exposure and infection
in elementary schools through the following specific aims: (1) To determine the efficacy of a randomized
placebo controlled HEPA cleaner intervention in reducing classroom airborne respiratory virus exposure; (2) To
determine the efficacy of a randomized placebo controlled HEPA cleaner intervention in reducing symptomatic
and asymptomatic respiratory viral infections in asthmatic children. The approach is innovative, because we
are simultaneously interrogating all major human respiratory viruses in the context of a school-based
randomized trial focused on an environmental intervention. The proposed research is significant, because if the
HEPA intervention can reduce respiratory virus exposure and infections in schools, it is an immediately
actionable and practical intervention to create safer indoor environments for elementary school children.
Results from this proposal may be generalizable to other public indoor settings.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Molecular epidemiology of respiratory virus exposure in elementary schools
-
批准号:10646577
-
项目类别:
-
资助金额:$26.79万
-
财政年份:2023
-
负责人:Peggy Sue Lai
-
依托单位:
The school microbiome and asthma morbidity in inner-city children
-
批准号:10065492
-
项目类别:
-
资助金额:$79.7万
-
财政年份:2019
-
负责人:Peggy Sue Lai
-
依托单位:
The school microbiome and asthma morbidity in inner-city children
-
批准号:10541838
-
项目类别:
-
资助金额:$68.82万
-
财政年份:2019
-
负责人:Peggy Sue Lai
-
依托单位:
The school microbiome and asthma morbidity in inner-city children
-
批准号:10317083
-
项目类别:
-
资助金额:$66.75万
-
财政年份:2019
-
负责人:Peggy Sue Lai
-
依托单位:
Endotoxin, the airway transcriptome, and obstructive lung disease
-
批准号:9066670
-
项目类别:
-
资助金额:$15.28万
-
财政年份:2013
-
负责人:Peggy Sue Lai
-
依托单位:
Endotoxin, the airway transcriptome, and obstructive lung disease
-
批准号:8852128
-
项目类别:
-
资助金额:$15.28万
-
财政年份:2013
-
负责人:Peggy Sue Lai
-
依托单位:
Endotoxin, the airway transcriptome, and obstructive lung disease
-
批准号:8739644
-
项目类别:
-
资助金额:$15.23万
-
财政年份:2013
-
负责人:Peggy Sue Lai
-
依托单位:
Endotoxin, the airway transcriptome, and obstructive lung disease
-
批准号:8617465
-
项目类别:
-
资助金额:$15.34万
-
财政年份:2013
-
负责人:Peggy Sue Lai
-
依托单位:
Lung disease due to chronic endotoxin exposure in mouse and human models
-
批准号:8608942
-
项目类别:
-
资助金额:$1.48万
-
财政年份:2012
-
负责人:Peggy Sue Lai
-
依托单位:
Lung disease due to chronic endotoxin exposure in mouse and human models
-
批准号:8252322
-
项目类别:
-
资助金额:$6.65万
-
财政年份:2012
-
负责人:Peggy Sue Lai
-
依托单位:
海外基金