Administrative Core

行政核心

• 批准号: 10646339
• 负责人: Mina Kay Chung
• 金额: $ 16.1万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646339
• 关键词: Acceleration; Accounting; Address; Animal Experimentation; Animals; Atrial Fibrillation; Awareness; Back; Basic Science; Biological; Cell model; Cells; Clinic; Clinical; Collaborations; Communication; Data; Documentation; Electrophysiology (science); Ensure; Environment; Experimental Designs; Funding; Generations; Genes; Genetic; Genomics; Goals; Grant; Heart Atrium; Human; Human Subject Research; Information Dissemination; Leadership; Link; Maintenance; Manuscripts; Mentors; Metabolism; Monitor; Mus; National Heart, Lung, and Blood Institute; Office of Administrative Management; Oral; Participant; Performance; Pharmaceutical Preparations; Phenotype; Preparation; Preventive; Progress Reports; Reporting; Reproducibility; Research; Research Personnel; Resources; Schedule; Science; Scientist; Services; Systems Biology; Therapeutic; Time; Translating; Visit; Work; Writing; cardiac tissue engineering; design; experimental study; gene interaction; genome wide association study; human subject; meetings; mouse model; operation; professional atmosphere; professor; programs; responsible research conduct; sex; synergism

ADMINISTRATIVE CORE (AC) PROJECT/SUMMARY ABSTRACT The overall goals of the Administrative Core (AC) are to provide organizational, administrative, fiscal, communication, and reporting support to each Project and Core within the Program Project (P01), entitled "Atrial Fibrillation Post-GWAS: Mechanisms to Treatment." Our overall theme is to translate AF genomic discoveries back to the bedside, focusing on genes to mechanisms, genes to drugs, and interactions of genes with metabolism and environment. In conjunction with the Executive Committee (EC), consisting of the Program Director, Project Leads and Core Directors, the AC will promote collaboration and synergy for all P01 components; centrally monitor and evaluate their performance; and facilitate interactions with the Internal Advisory Board (IAB) and External Advisory Board (EAB). The AC will promote integration, efficiency of resource use, and organizational and administrative support. The AC will be essential in coordinating all communications and reviewing all activities among all Projects and all Cores. Importantly, the AC will work closely with the EC and Cores to coordinate generation, maintenance, and experimental use of human cell and mouse models that will optimize experimental design, use of these resources, and integration of all Projects and Cores to efficiently accelerate the Program towards completion of its goals. The aims of the Core are to: 1) Promote collaboration and integration of the Program by providing organizational and administrative support; 2) Facilitate scientific exchange, dissemination of results, and communications; 3) Evaluate and promote research progress; 4) Provide managerial and fiscal grant management; and 5) Ensure and monitor best practices, resource utilization and coordination. The Core will promote best practices for rigor and responsibility, animal and human subjects research, responsible conduct of research, and mentoring and coaching of early stage investigators. The AC will monitor Projects and Scientific Cores and assure that sex as a biological variable has been addressed. In summary, the Administrative Core will function to unify and coordinate activities amongst the Program Project participants. It will facilitate organizational and administrative management of the Program, provide centralized access and coordination for cell and mouse experiment planning, and enhance significance, scope and scale of the projects. The services of this core do not replicate efforts of established cores at Cleveland Clinic, making this core uniquely designed to support P01 investigators.

行政核心（AC） 项目/摘要 行政核心的总体目标是提供组织、行政、财政、 通信和报告支持每个项目和核心计划项目（P01）， GWAS后房颤：治疗机制。“我们的总体主题是将AF基因组 发现回到床边，专注于基因的机制，基因药物，以及相互作用， 基因与新陈代谢和环境的关系。与执行委员会（EC）一起， 项目主任、项目领导和核心主任，AC将促进合作和协同作用， 所有P01组件;集中监控和评估其性能;并促进与 内部咨询委员会（IAB）和外部咨询委员会（EAB）。AC将促进融合， 资源使用效率以及组织和行政支助。AC将是必不可少的， 协调所有项目和所有核心之间的所有沟通并审查所有活动。重要的是， AC将与EC和Cores密切合作，以协调发电、维护和实验 使用人类细胞和小鼠模型，优化实验设计，使用这些资源，以及 整合所有项目和核心，以有效地加速计划实现其目标。 核心的目标是：1）通过提供 组织和行政支持; 2）促进科学交流，传播成果， 交流; 3）评估和促进研究进展; 4）提供管理和财政资助 确保和监测最佳做法、资源利用和协调。芯会 促进严谨和负责的最佳实践，动物和人类受试者研究，负责任 开展研究，并指导和指导早期阶段的调查人员。AC将监控 项目和科学核心，并确保性别作为一个生物变量得到解决。在 总而言之，行政核心将负责统一和协调该计划之间的活动 项目参与者。它将促进该方案的组织和行政管理， 为细胞和小鼠实验规划提供集中访问和协调，并增强 项目的意义、范围和规模。这一核心的服务并不重复 在Cleveland Clinic建立核心，使该核心设计独特，可支持P01研究者。