Administrative Core

行政核心

• 批准号: 10410644
• 负责人: Mina Kay Chung
• 金额: $ 16.1万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410644
• 关键词: Accounting; Address; Animal Experimentation; Animals; Atrial Fibrillation; Awareness; Back; Basic Science; Biological; Cell model; Cells; Clinic; Clinical; Collaborations; Communication; Data; Documentation; Drug Interactions; Electrophysiology (science); Ensure; Environment; Experimental Designs; Funding; Generations; Genes; Genetic; Genomics; Goals; Grant; Heart Atrium; Human; Human Subject Research; Information Dissemination; Leadership; Link; Maintenance; Manuscripts; Mentors; Metabolism; Monitor; Mus; National Heart, Lung, and Blood Institute; Office of Administrative Management; Oral; Participant; Performance; Phenotype; Preparation; Preventive; Progress Reports; Reporting; Reproducibility; Research; Research Personnel; Resources; Schedule; Science; Scientist; Services; Systems Biology; Therapeutic; Time; Translating; Visit; Work; cardiac tissue engineering; design; experimental study; gene interaction; genome wide association study; human subject; meetings; mouse model; operation; professional atmosphere; professor; programs; responsible research conduct; sex; synergism

ADMINISTRATIVE CORE (AC) PROJECT/SUMMARY ABSTRACT The overall goals of the Administrative Core (AC) are to provide organizational, administrative, fiscal, communication, and reporting support to each Project and Core within the Program Project (P01), entitled "Atrial Fibrillation Post-GWAS: Mechanisms to Treatment." Our overall theme is to translate AF genomic discoveries back to the bedside, focusing on genes to mechanisms, genes to drugs, and interactions of genes with metabolism and environment. In conjunction with the Executive Committee (EC), consisting of the Program Director, Project Leads and Core Directors, the AC will promote collaboration and synergy for all P01 components; centrally monitor and evaluate their performance; and facilitate interactions with the Internal Advisory Board (IAB) and External Advisory Board (EAB). The AC will promote integration, efficiency of resource use, and organizational and administrative support. The AC will be essential in coordinating all communications and reviewing all activities among all Projects and all Cores. Importantly, the AC will work closely with the EC and Cores to coordinate generation, maintenance, and experimental use of human cell and mouse models that will optimize experimental design, use of these resources, and integration of all Projects and Cores to efficiently accelerate the Program towards completion of its goals. The aims of the Core are to: 1) Promote collaboration and integration of the Program by providing organizational and administrative support; 2) Facilitate scientific exchange, dissemination of results, and communications; 3) Evaluate and promote research progress; 4) Provide managerial and fiscal grant management; and 5) Ensure and monitor best practices, resource utilization and coordination. The Core will promote best practices for rigor and responsibility, animal and human subjects research, responsible conduct of research, and mentoring and coaching of early stage investigators. The AC will monitor Projects and Scientific Cores and assure that sex as a biological variable has been addressed. In summary, the Administrative Core will function to unify and coordinate activities amongst the Program Project participants. It will facilitate organizational and administrative management of the Program, provide centralized access and coordination for cell and mouse experiment planning, and enhance significance, scope and scale of the projects. The services of this core do not replicate efforts of established cores at Cleveland Clinic, making this core uniquely designed to support P01 investigators.

管理核心(AC) 项目/摘要摘要 行政核心(AC)的总体目标是提供组织、行政、财政、 对方案项目内的每个项目和核心的沟通和报告支持(P01)，题为 “GWA后的房颤：治疗机制。”我们的总体主题是翻译AF基因组 回到床边的发现，集中在基因到机制，基因到药物，以及 基因与新陈代谢和环境有关。与执行委员会(欧委会)合作，由以下机构组成 项目总监、项目负责人和核心总监，AC将促进以下方面的协作和协同 所有P01组件；集中监控和评估其性能；并促进与 内部咨询委员会(IAB)和外部咨询委员会(EAB)。协调委员会将促进融合， 资源使用效率，以及组织和行政支持。空调在未来将是必不可少的 协调所有沟通，审查所有项目和所有核心之间的所有活动。重要的是 AC将与EC和堆芯密切合作，协调发电、维护和实验 使用人类细胞和小鼠模型，将优化实验设计，利用这些资源，以及 整合所有项目和核心，以有效地加速该计划实现其目标。 核心计划的目标是：1)通过提供以下内容促进计划的协作和整合 组织和行政支助；2)促进科学交流、成果传播和 交流；3)评估和促进研究进展；4)提供管理和财政资助 管理；以及5)确保和监测最佳做法、资源利用和协调。核心意志 促进严谨和负责的最佳做法，动物和人类对象研究，负责任 进行研究，并对早期调查人员进行指导和指导。空调将监控 项目和科学核心，并确保性别作为一个生物变量已经得到解决。在……里面 总而言之，行政核心将负责统一和协调计划中的活动 项目参与者。它将促进该方案的组织和行政管理， 为细胞和鼠标实验计划提供集中访问和协调，并增强 项目的意义、范围和规模。此核心的服务不会复制 在克利夫兰诊所建立的核心，使这个核心独特地设计来支持P01调查人员。