Cancer Genomics and Genomic Data Science for East Africa

东非癌症基因组学和基因组数据科学

• 批准号: 10646462
• 负责人: Jackson Orem
• 金额: $ 26.9万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646462
• 关键词: Acceleration; Address; Advanced Malignant Neoplasm; Africa; African; Bioinformatics; Cancer Patient; Collaborations; Communicable Diseases; Communities; Data; Data Science; Dedications; Development; Diagnosis; Doctor' s Degree; Ensure; Fred Hutchinson Cancer Research Center; Generations; Genetic Variation; Genome; Genomics; Health Sciences; Home; Human Genetics; Human Genome; Individual; Infrastructure; Institution; Malignant Neoplasms; Master of Science; Patients; Prevention; Prevention approach; Publications; Reproducibility; Research; Scientist; The Cancer Genome Atlas; Training; Uganda; Universities; anticancer research; cancer genome; cancer genomics; cancer therapy; clinical care; college; genomic data; improved; programs; tumor; whole genome

PROJECT SUMMARY/ABSTRACT The 20 years since publication of the draft human genome sequence in 2001 have been a truly transformational era in the field of cancer research marked by ever more significant scientific milestones and a steadily accelerating rate of progress. Global scientific initiatives focused on comprehensive characterization of tumor genomes – such as The Cancer Genome Atlas (TCGA) and the Pan-Cancer Analysis of Whole Genomes (PCAWG) – are radically transforming our approach to the prevention, diagnosis, and treatment of cancer. Surprisingly, although both TCGA and PCAWG included tumors from patients on many continents, few tumors from Africa were included in their analyses. Moreover, the number of African scientists involved in the two projects was limited. The paucity of African tumors analyzed by TCGA and PCAWG, and the dearth of African scientists involved in their analysis, is concerning given that Africa is home to 1.4 of the world’s 7.9 billion inhabitants, and much of human genetic variation is found only on the African continent. The profound under- representation of African genomes and tumors – and of African scientists – in cancer genomics studies is attributable to many factors, but the lack of requisite infrastructure for genomic research in Africa and the limited number of genomics professionals in Africa who are trained in both the generation and analysis of genomic data are major contributors. To ensure that the transformative benefits of recent advances in cancer genomics to the prevention, diagnosis, and treatment of cancer will be realized in Africa, dedicated initiatives must be undertaken to increase the number of trained genomics professionals in Africa. In this application, the Fred Hutchinson Cancer Research Center in Seattle, WA and the Uganda Cancer Institute in Kampala, Uganda – two premier institutions that have been collaborating since 2004 to conduct cancer research and to increase the capacity for high-quality cancer research, training, and clinical care in Uganda and East Africa – propose to extend their well- established collaboration to address the critical shortage of African genomics professionals who are trained in the generation and the analysis of cancer genomic data. We hypothesize that improving the supply of African professionals who can both generate cancer genomic data of reproducibly high quality and analyze those data rigorously and comprehensively will accelerate the development of an Africa-based cancer genomics community and ensure that the advances of the cancer genomics revolution will maximally benefit African cancer patients. Over a period of 5 years, and in conjunction with the Infectious Diseases Institute of the College of Health Sciences, Makerere University, the Fred Hutch and UCI will support 4 Ugandan or East African individuals who will complete master’s degrees, and 2 who will complete doctoral degrees, in Bioinformatics with a focus on cancer genomics and genomic data science. We anticipate that graduates of the program will become the leaders of the cancer genomics community in Uganda and East Africa.

项目总结/摘要 自2001年人类基因组测序草案发表以来的20年是一个真正的变革性时期。 癌症研究领域的新时代，标志着越来越多的重要科学里程碑和稳步增长。 加快进度。全球科学倡议专注于肿瘤的全面表征 基因组-如癌症基因组图谱（TCGA）和全基因组泛癌症分析 （PCAWG）-正在从根本上改变我们预防、诊断和治疗癌症的方法。 令人惊讶的是，尽管TCGA和PCAWG都包括来自许多大陆的患者的肿瘤，但很少有肿瘤 来自非洲的人也被纳入了他们的分析。此外，参与这两项研究的非洲科学家人数 项目有限。TCGA和PCAWG分析的非洲肿瘤的缺乏，以及非洲肿瘤的缺乏， 参与他们分析的科学家们，考虑到非洲是世界79亿人口中的14亿， 许多人类基因变异仅在非洲大陆发现。深刻的下- 代表非洲基因组和肿瘤-以及非洲科学家-在癌症基因组学研究中， 非洲基因组研究缺乏必要的基础设施， 非洲有许多基因组学专业人员接受过基因组数据生成和分析方面的培训 是主要贡献者。为了确保癌症基因组学最新进展的变革性益处， 为了在非洲实现癌症的预防、诊断和治疗，必须采取专门的举措， 增加非洲训练有素的基因组学专业人员的数量。在此应用程序中，Fred哈钦森 位于华盛顿州西雅图的癌症研究中心和位于乌干达坎帕拉的乌干达癌症研究所--两个 自2004年以来一直合作开展癌症研究并提高 在乌干达和东非开展高质量癌症研究、培训和临床护理， 建立了合作，以解决非洲基因组学专业人员的严重短缺问题， 癌症基因组数据的产生和分析。我们假设，改善非洲的供应 专业人员既可以生成可重复的高质量癌症基因组数据， 严格和全面地将加速非洲癌症基因组学社区的发展 并确保癌症基因组学革命的进展将最大限度地造福非洲癌症患者。 为期5年，并与卫生学院传染病研究所合作， 科学，Makerere大学，Fred Hutch和UCI将支持4名乌干达或东非人， 将完成硕士学位，2谁将完成博士学位，在生物信息学的重点是 癌症基因组学和基因组数据科学。我们预计，该计划的毕业生将成为 乌干达和东非癌症基因组学社区的领导人。