Advancing and applying peripheral and central auditory findings in HIV/AIDS.

推进和应用艾滋病毒/艾滋病的外周和中枢听觉发现。

• 批准号: 10647813
• 负责人: JAY C BUCKEY
• 金额: $ 71.18万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10647813
• 关键词: Acceleration; Address; Affect; Age; Aging; Anti-Retroviral Agents; Audiology; Auditory; Auditory system; Biometry; Brain; Central Nervous System; Clinical; Cognition; Cognitive; Cognitive deficits; Collaborations; Complex; Data; Development; Digit structure; Education; Evaluation; Future; Goals; HIV; HIV Infections; HIV/AIDS; Hearing; Hearing Tests; Human Resources; Impaired cognition; Individual; International; Longitudinal Studies; Longitudinal cohort; Longitudinal cohort study; Machine Learning; Measures; Mission; National Institute on Deafness and Other Communication Disorders; Neurocognitive; Neurocognitive Deficit; Noise; Otolaryngology; Participant; Patients; Performance; Peripheral; Persons; Pharmaceutical Preparations; Positioning Attribute; Research; Sensitivity and Specificity; Tanzania; Techniques; Test Result; Testing; Time; Training; United States National Institutes of Health; Work; age effect; antiretroviral therapy; auditory processing; clinical practice; cognitive performance; cognitive process; cognitive testing; cohort; comorbidity; comparison control; detection test; experience; follow-up; innovation; interest; literacy; longitudinal dataset; neurocognitive test; ototoxicity; performance tests; programs; response; screening; sound; speech in noise; treatment response

With NIH support, the Ubongo Sikivu cohort of both people living with HIV (PLWH) and uninfected controls was established in Tanzania and has had regular assessments of their peripheral hearing ability over 10+ years with detailed central auditory and neurocognitive assessments added over the last 5 years. This cohort is uniquely positioned to address the issues posed by PAR-20-127 “Advancing HIV/AIDS Research within the Mission of the NIDCD.” Data from the cohort has already answered important questions about the ototoxicity of anti-retrovirals, the effects of HIV infection and treatment on both peripheral and central hearing parameters, and the relationship of central auditory test (CAT) results to neurocognitive performance. By following this cohort longitudinally questions about how CATs could be used to predict or track neurocognitive performance and how age and long-term anti-retroviral treatment affect the auditory system can be answered. To date, the most significant result has been demonstrating that CAT results correlate with cognitive performance. This suggests CAT results might be useful for forecasting or tracking cognitive decline over time. The next important steps are determining whether worsening CAT performance precedes the later development of cognitive deficits in PLWH and which central auditory tests and other variables can predict neurocognitive deficits accurately. Neurocognitive screening tests are often sensitive to education, literacy, and culture. Full neurocognitive test batteries can be difficult to employ, particularly in the developing world where clinician time is limited, few trained personnel are available, and normative data often do not exist. Using CATs would be a major advance for following HIV+ patients because the CATs can be short (a gap detection test takes 5 minutes), easy to explain (the hearing-in-noise test and triple digit task involve identifying words or numbers in background noise), or effortless for the subject (the FFR test requires no subject input at all). This project’s goal is tracking the trajectory of peripheral auditory, central auditory, and neurocognitive performance over time by continuing to follow this cohort. With these longitudinal data machine learning and other statistical techniques will be applied to assess which factors forecast the subsequent development of cognitive deficits and which factors or combination of factors identify those with existing neurocognitive deficits. An international team with experience in central auditory testing and neurocognitive testing in PLWH has been assembled. Dr. Nina Kraus and her Northwestern team are internationally recognized experts in the auditory FFR. The Dar es Salaam team has extensive experience in otolaryngology and performing peripheral auditory, central auditory, and neurocognitive tests. Drs. Roth and Boivin are experts in assessing neurocognitive function. Dr. Gui has diverse biostatistical experience. Dr. Niemczak is an expert in peripheral and central auditory processing. This team and longitudinal cohort offer the unique ability to assess the use of CATs in evaluating cognition as well as the effects of aging and medications on both central and peripheral auditory function in PLWH.

在美国国立卫生研究院的支持下，Ubongo Sikivu队列包括艾滋病毒感染者（PLWH）和未感染的对照者