Duke Radiation Oncology and Radiology Stimulating Access to Research in Residency

杜克大学放射肿瘤学和放射学促进住院医师研究的机会

• 批准号: 10647795
• 负责人: Scott R Floyd
• 金额: $ 55.88万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-05 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10647795
• 关键词: Academic Medical Centers; Address; Advanced Malignant Neoplasm; American; Applications Grants; Area; Basic Science; Biomedical Engineering; Board Certification; Cancer Biology; Cancer Detection; Cancer Patient; Certification; Clinical Research; Clinical Sciences; Communication; Communities; Dedications; Detection; Development; Development Plans; Diagnosis; Diagnostic radiologic examination; Discipline; Doctor of Philosophy; Eligibility Determination; Ensure; Extramural Activities; Faculty; Fellowship; Fostering; Funding; Future; Goals; Grant; Image; Individual; Institution; Interventional radiology; Investigation; Journals; Lead; Malignant Neoplasms; Manuscripts; Mentors; Mission; Pathway interactions; Patients; Physicians; Physicians' Offices; Play; Positioning Attribute; Radiation Oncologist; Radiation Oncology; Radiation therapy; Radiobiology; Radiology Specialty; Research; Research Personnel; Research Priority; Research Project Grants; Research Training; Residencies; Resources; Role; Scholarship; Scientist; Staging; Talents; Therapeutic; Time; Training; Translational Research; Universities; Wages; Writing; anticancer research; cancer diagnosis; cancer therapy; career; career development; clinical development; clinical training; diagnostic strategy; didactic education; early phase clinical trial; experience; image guided; image guided therapy; imaging approach; imaging program; imaging study; improved; innovation; instructor; interest; medical schools; medical specialties; meetings; multidisciplinary; next generation; novel; novel diagnostics; novel therapeutic intervention; oncology program; preclinical imaging; preference; programs; radiologist; response; success; translational study

Advances in imaging and radiation therapy have the potential to spark widespread improvements in cancer diagnosis and treatment. However, a major barrier to progress in Radiation Oncology and Radiology is a shortage of physician-scientists with the necessary training to make transformative discoveries. Therefore, there is an urgent need to develop novel pathways for extended mentored research to retain more radiation oncologists and radiologists in research. To address this gap, we propose a Duke Radiation Oncology and Radiology Stimulating Access to Research in Residency (Duke ROR StARR) Program, with its central mission to cultivate Resident-Investigators in Radiation Oncology and Radiology through protected time to perform mentored research, therefore creating a cadre of physician-scientists who will make future discoveries that advance imaging and treatment of cancer. With a multi-departmental strategy spanning clinical and basic science departments, Resident-Investigators will experience individualized, multifaceted, and continuous training, embedded within a robust, institutional framework for physician scientist support. A team of multi- disciplinary, well-funded faculty Preceptors, as well as a group of talented Rising Preceptors, offer research opportunities in areas along the cancer research continuum from basic radiation and cancer biology, to pre- clinical imaging and translational studies, to early phase clinical trials. These areas address NCI strategic research priorities that include dissecting pathobiological mechanisms of cancer and developing novel diagnostic and therapeutic strategies. The program will consist of five training Aims: (1) Comprehensive didactics on professional development and basic, translational, and clinical research; (2) A research project and individual career development plan; (3) Scholarly activity; (4) Board eligibility for the American Board of Radiology; and (5) A path for continued post-residency mentored research training with sub-specialty clinical development. Led by PI David Kirsch (Radiation Oncology), Associate Program Directors Joseph Lo (Radiology) and Scott Floyd (Radiation Oncology), and departmental Residency Program Directors, the program will support three Resident-Investigators in Radiation Oncology, Diagnostic Radiology and/or Interventional Radiology per year, who will complete 12-24 months of mentored research. Institutional support including resources from the Office of Physician Scientist Development, departmental salary support, a research supplement funded by the School of Medicine, and preferences for a subspecialty fellowship or research-intensive Instructor position at Duke supported by the Duke Cancer Institute will ensure that after completing the program, these individuals will be poised to become the next generation of physicians to lead research in Radiation Oncology and Radiology. Achieving the Program's objectives will fulfill urgent needs for: 1) more physician-scientists in Radiation Oncology and Radiology and 2) innovations in imaging, cancer biology, and radiation oncology to transform the lives of cancer patients.

成像和放射治疗的进步有可能引发癌症的广泛改善 诊断和治疗。然而，放射肿瘤学和放射学进展的主要障碍是 缺乏经过必要培训的医生科学家，以做出变革性的发现。因此，我们认为， 迫切需要开发新的途径来进行扩展的指导研究，以保留更多的辐射 肿瘤学家和放射学家。为了解决这一差距，我们提出了一个杜克放射肿瘤学和 放射学刺激访问住院医师研究（杜克ROR StARR）计划，其中央 使命是通过受保护的时间培养放射肿瘤学和放射学的住院研究者， 进行指导性研究，从而培养出一批未来将有新发现的医学科学家 从而推动了癌症的成像和治疗。通过跨临床和基础的多部门战略， 科学部门，驻地调查员将体验个性化，多方面和连续的 培训，嵌入在一个强大的，机构框架内的医生科学家的支持。一个多人的团队-- 学科，资金充足的教师预测，以及一组有才华的上升预测，提供研究 机会在领域沿着癌症研究连续体从基础辐射和癌症生物学， 临床成像和转化研究，到早期临床试验。这些领域涉及NCI战略 研究重点，包括解剖癌症的病理生物学机制和开发新的 诊断和治疗策略。该方案将包括五个培训目标：（1）全面 专业发展和基础，转化和临床研究的教学法;（2）研究项目 （3）学术活动;（4）美国董事会的董事会资格; 放射学;和（5）继续住院医师指导的研究培训与亚专业临床 发展由PI大卫基尔希（放射肿瘤学），副项目主任约瑟夫罗 （放射学）和斯科特弗洛伊德（放射肿瘤学），和部门住院医师项目主任， 该计划将支持放射肿瘤学，诊断放射学和/或 介入放射学每年，谁将完成12-24个月的指导研究。体制 支持，包括来自医生科学家发展办公室的资源，部门工资支持， 由医学院资助的研究补充，以及对亚专业奖学金的偏好，或 由杜克癌症研究所支持的杜克研究密集型讲师职位将确保 完成该计划后，这些人将有望成为下一代的医生领导 放射肿瘤学和放射学研究。实现该方案的目标将满足以下方面的迫切需要： 1)更多的放射肿瘤学和放射学的医生科学家和2）成像，癌症 生物学和放射肿瘤学来改变癌症患者的生活。

项目成果

Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases.

• DOI: 10.1016/j.adro.2022.101054
• 发表时间: 2022-11
• 期刊: ADVANCES IN RADIATION ONCOLOGY
• 影响因子: 2.3
• 作者: Lerner, Emily C;Srinivasan, Ethan S;Broadwater, Gloria;Haskell-Mendoza, Aden P;Edwards, Ryan M;Huie, David;Vaios, Eugene J;Floyd, Scott R;Adamson, Justus D;Fecci, Peter E
• 通讯作者: Fecci, Peter E

Combination laser interstitial thermal therapy plus stereotactic radiotherapy increases time to progression for biopsy-proven recurrent brain metastases.

• DOI: 10.1093/noajnl/vdac086
• 发表时间: 2022-01
• 期刊: Neuro-oncology advances

Novel Mechanisms and Future Opportunities for the Management of Radiation Necrosis in Patients Treated for Brain Metastases in the Era of Immunotherapy.

• DOI: 10.3390/cancers15092432
• 发表时间: 2023-04-24
• 期刊: Cancers
• 影响因子: 5.2

Outcomes in Patients with Intact and Resected Brain Metastasis Treated with 5-Fraction Stereotactic Radiosurgery.

采用 5 分次立体定向放射外科治疗的完整脑转移瘤和已切除脑转移瘤患者的结果。

• DOI: 10.1016/j.adro.2022.101166
• 发表时间: 2023-03
• 期刊: Advances in radiation oncology
• 影响因子: 2.3

Prognostic Model for Intracranial Progression after Stereotactic Radiosurgery: A Multicenter Validation Study.

• DOI: 10.3390/cancers14215186
• 发表时间: 2022-10-22
• 期刊: CANCERS
• 影响因子: 5.2
• 作者: Carpenter, David J.;Natarajan, Brahma;Arshad, Muzamil;Natesan, Divya;Schultz, Olivia;Moravan, Michael J.;Read, Charlotte;Lafata, Kyle J.;Giles, Will;Fecci, Peter;Mullikin, Trey C.;Reitman, Zachary J.;Kirkpatrick, John P.;Floyd, Scott R.;Chmura, Steven J.;Hong, Julian C.;Salama, Joseph K.
• 通讯作者: Salama, Joseph K.