The Changing Epidemiology of Lung Health: Opportunities for Research on Cannabis and HIV Disease (The ORCHID Study)

肺部健康流行病学的变化:大麻和艾滋病毒研究的机会(ORCHID 研究)

基本信息

项目摘要

Project Summary / Abstract Consumption of cannabis products is increasing in the United States. The prevalence of past month use among adults has grown from 5.8% in 2007 to 11.5% in 2019. Causes of this increase include an evolving regulatory environment, product innovations by the cannabis industry, and cultural trends towards greater permissiveness. The effect of exposure to cannabis products on lung health are not fully understood, so the public health impact of increased cannabis consumption cannot be fully appreciated. In a recent report, the National Academy of Science, Engineering, and Medicine highlighted the critical need for more research to determine whether long term exposure to cannabis leads to chronic lung disease. The overall objective of this proposal is to examine the effects of cannabis exposure on lung health. This proposal leverages a longstanding, NHLBI-funded multi-center cohort of adults living with or at risk for HIV infection—the MACS/WIHS Combined Cohort Study—in which the lifetime prevalence of cannabis exposure exceeds 70%. The specific aims of the proposal are to: (1) measure the association of self-reported cumulative exposure to cannabis with lung function in persons living with or without HIV; (2) measure the effect of biochemically- verified cannabis exposure on the change in lung function in persons living with and without HIV; and (3) pilot a novel instrument for measuring exposure to different cannabis products among persons living with and without HIV. The objective and aims of this proposal are in line with the NHLBI’s Strategic Goal to “reduce human disease” through “clinical investigations that advance the prediction, prevention, preemption, treatment, and cures of human [lung] diseases.” In particular, this proposal is responsive to Compelling Question 2.CQ.03, “What biomarkers of… environmental exposure are predictive of disease onset or progression?” and Critical Challenge 3.CC.04, “Advances in methods and models for assessing and characterizing exposures are needed to understand differences in health among populations.” The benefits of the proposed research are expected to accrue broadly to the public health and welfare of current and future Americans. This K23 award supports mentored career development for Richard Wang, MD MAS, Assistant Professor of Medicine at the University of California San Francisco (UCSF). Dr. Wang’s long-term career goal is to become an independent clinician investigator focused on improving the respiratory health of vulnerable populations, including persons with HIV. His short-term goal is to better understand the risks to respiratory health posed by the rapidly changing prevalence and practices of cannabis consumption among the American public. This K23 award supports Dr. Wang to develop expertise in: statistical methods for causal inference from complex observational data; the biochemical measurement of cannabis metabolites in biological samples; and the measurement of cannabis use with survey instruments. Dr. Wang benefits from a superb mentoring team with complementary scientific expertise and a vibrant scientific milieu at UCSF for rigorous multi-disciplinary research and training.
项目总结/摘要 美国大麻产品的消费量正在增加。过去一个月的使用率 成年人的比例从2007年的5.8%上升到2019年的11.5%。这种增长的原因包括不断发展的 监管环境、大麻业的产品创新以及大麻生产的文化趋势, 宽容暴露于大麻产品对肺部健康的影响尚未完全了解,因此, 大麻消费量增加对公共卫生的影响无法得到充分认识。在最近的一份报告中 美国国家科学、工程和医学院强调,迫切需要进行更多的研究, 确定长期接触大麻是否会导致慢性肺病。本报告的总体目标 该提案旨在研究大麻暴露对肺部健康的影响。该提案利用了 长期以来,NHLBI资助的多中心队列的成年人生活或艾滋病毒感染的风险, MACS/WIHS联合队列研究-大麻暴露的终生患病率超过70%。 该提案的具体目标是:(1)测量自我报告的累积暴露与 大麻与肺功能的人生活或没有艾滋病毒;(2)测量生物化学的影响- 经核实的大麻暴露对艾滋病毒感染者和非艾滋病毒感染者肺功能变化的影响;以及(3)试点 用于测量有和没有大麻的人接触不同大麻产品的新仪器 艾滋病。该提案的目标和宗旨符合NHLBI的战略目标,即“减少人类死亡”。 疾病”通过“临床研究,推进预测,预防,先发制人,治疗, 治人之病”。特别是,本提案对强制性问题2.CQ.03做出了回应, “环境暴露的哪些生物标志物可预测疾病的发作或进展?”和关键 挑战3.CC.04,“评估和描述暴露的方法和模型的进展, 需要了解不同人群的健康差异。”拟议研究的好处是 预计将对当前和未来美国人的公共健康和福利产生广泛影响。K23奖项 支持理查德王,医学博士MAS,医学助理教授在指导职业发展 加州旧金山弗朗西斯科大学(UCSF)。王博士的长期职业目标是成为一名独立的 临床研究人员专注于改善弱势群体的呼吸系统健康,包括 感染了艾滋病毒他的短期目标是更好地了解快速呼吸道疾病对呼吸系统健康造成的风险。 改变美国公众大麻消费的流行程度和做法。K23奖项 支持王博士发展以下方面的专业知识:从复杂的观察数据中进行因果推断的统计方法 数据;生物样品中大麻代谢物的生物化学测量;以及 使用调查工具。王博士受益于一个优秀的指导团队, 科学专业知识和UCSF充满活力的科学环境,进行严格的多学科研究和培训。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Race Arithmetic of the Global Lung Function Initiative Global Reference Equations.
全球肺功能倡议全球参考方程的种族算法。
Beyond Race-Specific Spirometry Reference Equations: What Comes Next?
超越特定种族肺活量测定参考方程:接下来会发生什么?
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Richard Jin-yuan Wang其他文献

Richard Jin-yuan Wang的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Richard Jin-yuan Wang', 18)}}的其他基金

The Changing Epidemiology of Lung Health: Opportunities for Research on Cannabis and HIV Disease (The ORCHID Study)
肺部健康流行病学的变化:大麻和艾滋病毒研究的机会(ORCHID 研究)
  • 批准号:
    10403339
  • 财政年份:
    2022
  • 资助金额:
    $ 20.12万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 20.12万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 20.12万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 20.12万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 20.12万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 20.12万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 20.12万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 20.12万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 20.12万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 20.12万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 20.12万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了