The Changing Epidemiology of Lung Health: Opportunities for Research on Cannabis and HIV Disease (The ORCHID Study)
肺部健康流行病学的变化:大麻和艾滋病毒研究的机会(ORCHID 研究)
基本信息
- 批准号:10650755
- 负责人:
- 金额:$ 20.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdultAffectAmericanAreaBiochemicalBiologicalBiological MarkersCaliforniaCannabisChronicChronic lung diseaseCohort StudiesComplexConsequences of HIVConsumptionDataData ReportingDiseaseDisease ProgressionEngineeringEnvironmentEnvironmental ExposureEpidemiologyExposure toFundingFutureGoalsHIVHIV InfectionsHealthHigh PrevalenceHumanImmuneImpairmentIndustryInterdisciplinary StudyLinkLong-Term EffectsLongitudinal cohortLungMarijuana SmokingMeasurementMeasuresMedical MarijuanaMedicineMentored Patient-Oriented Research Career Development AwardMentorsMethodsModelingNational Heart, Lung, and Blood InstituteOilsOnset of illnessOutcomeParticipantPatient Self-ReportPersonsPopulationPrevalencePreventionPublic HealthRecreationReportingResearchResearch PersonnelRespiratory Signs and SymptomsRiskSamplingSan FranciscoScoring MethodStatistical MethodsSurveysTrainingUnited StatesUnited States National Academy of SciencesUniversitiesUrineVulnerable PopulationsWaxescareercareer developmentcigarette smokingclinical investigationclinical research sitecohortevidence baseexposure to cigarette smokehealth differencehuman diseaseimprovedinjured airwayinnovationinsightinstrumentlung healthmarijuana legalizationmarijuana usemarijuana usernovelpermissivenessprofessorpulmonary functionrespiratory healthsocialtrendvapingwelfare
项目摘要
Project Summary / Abstract
Consumption of cannabis products is increasing in the United States. The prevalence of past month use
among adults has grown from 5.8% in 2007 to 11.5% in 2019. Causes of this increase include an evolving
regulatory environment, product innovations by the cannabis industry, and cultural trends towards greater
permissiveness. The effect of exposure to cannabis products on lung health are not fully understood, so the
public health impact of increased cannabis consumption cannot be fully appreciated. In a recent report, the
National Academy of Science, Engineering, and Medicine highlighted the critical need for more research to
determine whether long term exposure to cannabis leads to chronic lung disease. The overall objective of this
proposal is to examine the effects of cannabis exposure on lung health. This proposal leverages a
longstanding, NHLBI-funded multi-center cohort of adults living with or at risk for HIV infection—the
MACS/WIHS Combined Cohort Study—in which the lifetime prevalence of cannabis exposure exceeds 70%.
The specific aims of the proposal are to: (1) measure the association of self-reported cumulative exposure to
cannabis with lung function in persons living with or without HIV; (2) measure the effect of biochemically-
verified cannabis exposure on the change in lung function in persons living with and without HIV; and (3) pilot a
novel instrument for measuring exposure to different cannabis products among persons living with and without
HIV. The objective and aims of this proposal are in line with the NHLBI’s Strategic Goal to “reduce human
disease” through “clinical investigations that advance the prediction, prevention, preemption, treatment, and
cures of human [lung] diseases.” In particular, this proposal is responsive to Compelling Question 2.CQ.03,
“What biomarkers of… environmental exposure are predictive of disease onset or progression?” and Critical
Challenge 3.CC.04, “Advances in methods and models for assessing and characterizing exposures are
needed to understand differences in health among populations.” The benefits of the proposed research are
expected to accrue broadly to the public health and welfare of current and future Americans. This K23 award
supports mentored career development for Richard Wang, MD MAS, Assistant Professor of Medicine at the
University of California San Francisco (UCSF). Dr. Wang’s long-term career goal is to become an independent
clinician investigator focused on improving the respiratory health of vulnerable populations, including persons
with HIV. His short-term goal is to better understand the risks to respiratory health posed by the rapidly
changing prevalence and practices of cannabis consumption among the American public. This K23 award
supports Dr. Wang to develop expertise in: statistical methods for causal inference from complex observational
data; the biochemical measurement of cannabis metabolites in biological samples; and the measurement of
cannabis use with survey instruments. Dr. Wang benefits from a superb mentoring team with complementary
scientific expertise and a vibrant scientific milieu at UCSF for rigorous multi-disciplinary research and training.
项目概要/摘要
美国大麻产品的消费量正在增加。过去一个月的使用率
成年人的死亡率从 2007 年的 5.8% 增长到 2019 年的 11.5%。这种增长的原因包括不断变化的
监管环境、大麻行业的产品创新以及更广泛的文化趋势
宽容。接触大麻产品对肺部健康的影响尚不完全清楚,因此
大麻消费增加对公共健康的影响尚未得到充分认识。在最近的一份报告中,
美国国家科学、工程和医学院强调迫切需要进行更多研究
确定长期接触大麻是否会导致慢性肺部疾病。本次活动的总体目标
提案旨在研究大麻暴露对肺部健康的影响。该提案利用了
由 NHLBI 资助的长期、多中心的艾滋病毒感染者或有感染风险的成年人队列——
MACS/WIHS 联合队列研究——终生接触大麻的患病率超过 70%。
该提案的具体目标是:(1)衡量自我报告的累积暴露与
大麻对感染或未感染艾滋病毒的人具有肺功能; (2) 测量生化效果-
核实大麻暴露对艾滋病毒感染者和未感染者肺功能变化的影响; (3) 试点
用于测量吸食和不吸食大麻的人接触不同大麻产品的新型仪器
艾滋病病毒。该提案的目的和宗旨与 NHLBI 的战略目标“减少人力
通过“临床研究推进预测、预防、抢占、治疗和预防疾病”
治愈人类[肺部]疾病。”特别是,该提案是对引人注目的问题 2.CQ.03 的回应,
“环境暴露的哪些生物标志物可以预测疾病的发作或进展?”和关键
挑战 3.CC.04,“评估和表征暴露的方法和模型的进步
需要了解人群之间健康状况的差异。”拟议研究的好处是
预计将广泛促进当前和未来美国人的公共健康和福利。此次K23奖
支持理查德·王 (Richard Wang) 的职业发展,他是医学博士、医学博士、医学助理教授
加州大学旧金山分校 (UCSF)。王博士的长期职业目标是成为一名独立的
临床研究者专注于改善弱势群体的呼吸健康,包括个人
患有艾滋病毒。他的短期目标是更好地了解快速传播的病毒对呼吸系统健康造成的风险。
改变美国公众大麻消费的流行率和做法。此次K23奖
支持王博士发展以下方面的专业知识:从复杂的观察中进行因果推断的统计方法
数据;生物样品中大麻代谢物的生化测量;和测量
大麻与调查仪器的使用。王博士受益于优秀的导师团队,互补性强
加州大学旧金山分校拥有科学专业知识和充满活力的科学环境,可进行严格的多学科研究和培训。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Race Arithmetic of the Global Lung Function Initiative Global Reference Equations.
全球肺功能倡议全球参考方程的种族算法。
- DOI:10.1164/rccm.202303-0565le
- 发表时间:2024
- 期刊:
- 影响因子:24.7
- 作者:Wang,RichardJ
- 通讯作者:Wang,RichardJ
Beyond Race-Specific Spirometry Reference Equations: What Comes Next?
超越特定种族肺活量测定参考方程:接下来会发生什么?
- DOI:10.1164/rccm.202305-0921le
- 发表时间:2024
- 期刊:
- 影响因子:24.7
- 作者:Wang,RichardJ
- 通讯作者:Wang,RichardJ
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Richard Jin-yuan Wang其他文献
Richard Jin-yuan Wang的其他文献
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{{ truncateString('Richard Jin-yuan Wang', 18)}}的其他基金
The Changing Epidemiology of Lung Health: Opportunities for Research on Cannabis and HIV Disease (The ORCHID Study)
肺部健康流行病学的变化:大麻和艾滋病毒研究的机会(ORCHID 研究)
- 批准号:
10403339 - 财政年份:2022
- 资助金额:
$ 20.12万 - 项目类别:
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