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The Changing Epidemiology of Lung Health: Opportunities for Research on Cannabis and HIV Disease (The ORCHID Study)

肺部健康流行病学的变化：大麻和艾滋病毒研究的机会（ORCHID 研究）

基本信息

批准号：
10650755
负责人：
Richard Jin-yuan Wang
金额：
$ 20.12万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10650755
关键词：
Acute Address Adult Affect American Area Biochemical Biological Biological Markers California Cannabis Chronic Chronic lung disease Cohort Studies Complex Consequences of HIV Consumption Data Data Reporting Disease Disease Progression Engineering Environment Environmental Exposure Epidemiology Exposure to Funding Future Goals HIV HIV Infections Health High Prevalence Human Immune Impairment Industry Interdisciplinary Study Link Long-Term Effects Longitudinal cohort Lung Marijuana Smoking Measurement Measures Medical Marijuana Medicine Mentored Patient-Oriented Research Career Development Award Mentors Methods Modeling National Heart, Lung, and Blood Institute Oils Onset of illness Outcome Participant Patient Self-Report Persons Population Prevalence Prevention Public Health Recreation Reporting Research Research Personnel Respiratory Signs and Symptoms Risk Sampling San Francisco Scoring Method Statistical Methods Surveys Training United States United States National Academy of Sciences Universities Urine Vulnerable Populations Waxes career career development cigarette smoking clinical investigation clinical research site cohort evidence base exposure to cigarette smoke health difference human disease improved injured airway innovation insight instrument lung health marijuana legalization marijuana use marijuana user novel permissiveness professor pulmonary function respiratory health social trend vaping welfare

项目摘要

Project Summary / Abstract Consumption of cannabis products is increasing in the United States. The prevalence of past month use among adults has grown from 5.8% in 2007 to 11.5% in 2019. Causes of this increase include an evolving regulatory environment, product innovations by the cannabis industry, and cultural trends towards greater permissiveness. The effect of exposure to cannabis products on lung health are not fully understood, so the public health impact of increased cannabis consumption cannot be fully appreciated. In a recent report, the National Academy of Science, Engineering, and Medicine highlighted the critical need for more research to determine whether long term exposure to cannabis leads to chronic lung disease. The overall objective of this proposal is to examine the effects of cannabis exposure on lung health. This proposal leverages a longstanding, NHLBI-funded multi-center cohort of adults living with or at risk for HIV infection—the MACS/WIHS Combined Cohort Study—in which the lifetime prevalence of cannabis exposure exceeds 70%. The specific aims of the proposal are to: (1) measure the association of self-reported cumulative exposure to cannabis with lung function in persons living with or without HIV; (2) measure the effect of biochemically- verified cannabis exposure on the change in lung function in persons living with and without HIV; and (3) pilot a novel instrument for measuring exposure to different cannabis products among persons living with and without HIV. The objective and aims of this proposal are in line with the NHLBI’s Strategic Goal to “reduce human disease” through “clinical investigations that advance the prediction, prevention, preemption, treatment, and cures of human [lung] diseases.” In particular, this proposal is responsive to Compelling Question 2.CQ.03, “What biomarkers of… environmental exposure are predictive of disease onset or progression?” and Critical Challenge 3.CC.04, “Advances in methods and models for assessing and characterizing exposures are needed to understand differences in health among populations.” The benefits of the proposed research are expected to accrue broadly to the public health and welfare of current and future Americans. This K23 award supports mentored career development for Richard Wang, MD MAS, Assistant Professor of Medicine at the University of California San Francisco (UCSF). Dr. Wang’s long-term career goal is to become an independent clinician investigator focused on improving the respiratory health of vulnerable populations, including persons with HIV. His short-term goal is to better understand the risks to respiratory health posed by the rapidly changing prevalence and practices of cannabis consumption among the American public. This K23 award supports Dr. Wang to develop expertise in: statistical methods for causal inference from complex observational data; the biochemical measurement of cannabis metabolites in biological samples; and the measurement of cannabis use with survey instruments. Dr. Wang benefits from a superb mentoring team with complementary scientific expertise and a vibrant scientific milieu at UCSF for rigorous multi-disciplinary research and training.

项目摘要/摘要