The Changing Epidemiology of Lung Health: Opportunities for Research on Cannabis and HIV Disease (The ORCHID Study)
肺部健康流行病学的变化:大麻和艾滋病毒研究的机会(ORCHID 研究)
基本信息
- 批准号:10650755
- 负责人:
- 金额:$ 20.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdultAffectAmericanAreaBiochemicalBiologicalBiological MarkersCaliforniaCannabisChronicChronic lung diseaseCohort StudiesComplexConsequences of HIVConsumptionDataData ReportingDiseaseDisease ProgressionEngineeringEnvironmentEnvironmental ExposureEpidemiologyExposure toFundingFutureGoalsHIVHIV InfectionsHealthHigh PrevalenceHumanImmuneImpairmentIndustryInterdisciplinary StudyLinkLong-Term EffectsLongitudinal cohortLungMarijuana SmokingMeasurementMeasuresMedical MarijuanaMedicineMentored Patient-Oriented Research Career Development AwardMentorsMethodsModelingNational Heart, Lung, and Blood InstituteOilsOnset of illnessOutcomeParticipantPatient Self-ReportPersonsPopulationPrevalencePreventionPublic HealthRecreationReportingResearchResearch PersonnelRespiratory Signs and SymptomsRiskSamplingSan FranciscoScoring MethodStatistical MethodsSurveysTrainingUnited StatesUnited States National Academy of SciencesUniversitiesUrineVulnerable PopulationsWaxescareercareer developmentcigarette smokingclinical investigationclinical research sitecohortevidence baseexposure to cigarette smokehealth differencehuman diseaseimprovedinjured airwayinnovationinsightinstrumentlung healthmarijuana legalizationmarijuana usemarijuana usernovelpermissivenessprofessorpulmonary functionrespiratory healthsocialtrendvapingwelfare
项目摘要
Project Summary / Abstract
Consumption of cannabis products is increasing in the United States. The prevalence of past month use
among adults has grown from 5.8% in 2007 to 11.5% in 2019. Causes of this increase include an evolving
regulatory environment, product innovations by the cannabis industry, and cultural trends towards greater
permissiveness. The effect of exposure to cannabis products on lung health are not fully understood, so the
public health impact of increased cannabis consumption cannot be fully appreciated. In a recent report, the
National Academy of Science, Engineering, and Medicine highlighted the critical need for more research to
determine whether long term exposure to cannabis leads to chronic lung disease. The overall objective of this
proposal is to examine the effects of cannabis exposure on lung health. This proposal leverages a
longstanding, NHLBI-funded multi-center cohort of adults living with or at risk for HIV infection—the
MACS/WIHS Combined Cohort Study—in which the lifetime prevalence of cannabis exposure exceeds 70%.
The specific aims of the proposal are to: (1) measure the association of self-reported cumulative exposure to
cannabis with lung function in persons living with or without HIV; (2) measure the effect of biochemically-
verified cannabis exposure on the change in lung function in persons living with and without HIV; and (3) pilot a
novel instrument for measuring exposure to different cannabis products among persons living with and without
HIV. The objective and aims of this proposal are in line with the NHLBI’s Strategic Goal to “reduce human
disease” through “clinical investigations that advance the prediction, prevention, preemption, treatment, and
cures of human [lung] diseases.” In particular, this proposal is responsive to Compelling Question 2.CQ.03,
“What biomarkers of… environmental exposure are predictive of disease onset or progression?” and Critical
Challenge 3.CC.04, “Advances in methods and models for assessing and characterizing exposures are
needed to understand differences in health among populations.” The benefits of the proposed research are
expected to accrue broadly to the public health and welfare of current and future Americans. This K23 award
supports mentored career development for Richard Wang, MD MAS, Assistant Professor of Medicine at the
University of California San Francisco (UCSF). Dr. Wang’s long-term career goal is to become an independent
clinician investigator focused on improving the respiratory health of vulnerable populations, including persons
with HIV. His short-term goal is to better understand the risks to respiratory health posed by the rapidly
changing prevalence and practices of cannabis consumption among the American public. This K23 award
supports Dr. Wang to develop expertise in: statistical methods for causal inference from complex observational
data; the biochemical measurement of cannabis metabolites in biological samples; and the measurement of
cannabis use with survey instruments. Dr. Wang benefits from a superb mentoring team with complementary
scientific expertise and a vibrant scientific milieu at UCSF for rigorous multi-disciplinary research and training.
项目摘要/摘要
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Race Arithmetic of the Global Lung Function Initiative Global Reference Equations.
全球肺功能倡议全球参考方程的种族算法。
- DOI:10.1164/rccm.202303-0565le
- 发表时间:2024
- 期刊:
- 影响因子:24.7
- 作者:Wang,RichardJ
- 通讯作者:Wang,RichardJ
Beyond Race-Specific Spirometry Reference Equations: What Comes Next?
超越特定种族肺活量测定参考方程:接下来会发生什么?
- DOI:10.1164/rccm.202305-0921le
- 发表时间:2024
- 期刊:
- 影响因子:24.7
- 作者:Wang,RichardJ
- 通讯作者:Wang,RichardJ
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Richard Jin-yuan Wang其他文献
Richard Jin-yuan Wang的其他文献
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{{ truncateString('Richard Jin-yuan Wang', 18)}}的其他基金
The Changing Epidemiology of Lung Health: Opportunities for Research on Cannabis and HIV Disease (The ORCHID Study)
肺部健康流行病学的变化:大麻和艾滋病毒研究的机会(ORCHID 研究)
- 批准号:
10403339 - 财政年份:2022
- 资助金额:
$ 20.12万 - 项目类别:
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