Reciprocity of Social Connection and Well-Being: Convergence of Temporal and Neural Underpinnings of Adolescent Social Connection Quality, Quantity, and Need

项目摘要/摘要 人类天生就是社会性生物，其中社会关系(SC)对于优化幸福感至关重要 (WB)，1-3，包括积极的感觉、知觉、日常生活中的功能和心理缺失 问题和病理性的痛苦。4，5这在青春期尤其关键，青春期是一种敏感的发育 在他们的一般社会关系(以及#年的同辈和家庭领域)发生重大和迅速变化的时期 6社会孤立(即缺乏自闭感)是青少年心理和身体的主要危险因素之一 健康问题，7-9岁，同时有足够的SC是他们长期工作和公民生活的一个强有力的促进因素 7，10，11 SC是一个多方面的结构，包括质量，数量， 和对社交的需要，2，12-14，每个都对青少年健康和WB.14-21有独特的影响 然而，关于这些方面是如何汇聚并预测(或被预测)青少年WB的知之甚少。 SC的神经生物学标志物与WB.22-24有关的时间或程度本项目的总体目标 是评估供应链质量、数量和需求的综合方面，以及它们的相互关联 在日常波动、长期轨迹和神经生物学过程中，青春期的WB。 提出的项目科学目标是：(1)评估SC和WB之间的短期互惠过程；(2) 检查SC星座和WB轨迹之间的长期互惠关系；以及(3)确定 系统性红斑狼疮的行为和神经生物学标记物的趋同及其与WB的前瞻性关联。 探索性分析将(A)探索性别、性别、年龄、青春期状态和 种族和(B)在同伴和家庭特定的SC背景下考虑上述三个目标。研究设计：第一项 将通过一个在线平台实现两个目标，以确保12-17岁青少年的大样本使用 一项为期14天的每日日记设计嵌套在纵向研究设计(N=914入选；T1-T2-T3，每0.5年)。 一部分参与者(n=104名已注册)也将完成SC的面对面测试(在T1和T3 在脑电(EEG)和眼球跟踪过程中针对三个SC方面的每一个的实验任务 (ET)收购。为了评估短期的互惠过程，我们将使用以下每日问卷评估 SC和WB审查SC和WB之间的当天和次日关联(目标1)。要提供一个 综合考虑SC的三个方面，我们将根据青少年的经验确定他们的亚群 SC质量、数量和需求(分别为T1、T3)和WB轨迹(T1-T2-T3)，并检查 SC星座和WB轨道之间的预期转移概率(目标2)。最后，我们将评估 系统性红斑狼疮(T1和T3)行为和神经生物学标志物的趋同性及其前景 与世界银行的联系(目标3)。意义：更深入地理解供应链之间的互惠关系 而WB和这些关联背后的神经生物学机制将对机制- 知情的预防方案编制。

PROJECT SUMMARY/ABSTRACT Humans are inherently social creatures, wherein social connection (SC) is essential for optimizing well-being (WB),1–3 including positive feelings, perceptions, and functioning in daily life and the absence of psychological problems and pathological distress.4,5 This is especially critical during adolescence, a sensitive developmental period with substantial and rapid changes in their general social connections (and in peer and family domains in particular).6 Social isolation (i.e. lacking SC) is one of the primary risk factors for adolescent mental and physical health problems,7–9 while having sufficient SC is a strong facilitative factor for their long-term WB and civic engagement in adulthood.7,10,11 SC is a multi-faceted construct that includes the facets of quality of, quantity of, and need for social interactions,2,12–14 each demonstrating unique influences on adolescent health and WB.14–21 However, little is known about how these facets converge and predict (or are predicted by) adolescent WB over time or the extent by which neurobiological markers of SC relate to WB.22–24 The overall objective of the project is to evaluate the integrative facets of SC quality, quantity, and need, and their reciprocal associations with adolescent WB, in daily fluctuations, long-term trajectories, and neurobiological processes. Proposed project scientific goals are to: (1) Evaluate short-term reciprocal process between SC and WB; (2) Examine the long-term reciprocity between SC constellations and WB trajectories; and (3) Identify the convergence of behavioral and neurobiological markers of SC and their prospective associations with WB. Exploratory analyses will (a) explore modulation of these processes by sex, gender, age, pubertal status, and race and (b) consider the above three goals in peer- and family- specific SC contexts. Study design: The first two goals will be addressed via an online platform to ensure a large sample of 12-17-year-old adolescents using a 14-day daily diary design nested within a longitudinal study design (N=914 enrolled; T1-T2-T3, every 0.5 year). A subset of participants (n=104 enrolled) will also complete an in-person battery (at T1 and T3) of SC experimental tasks targeting each of the three SC facets during electroencephalography (EEG) and eye tracking (ET) acquisition. To evaluate the short-term reciprocal process, we will use daily questionnaire assessments of SC and WB to examine the same-day and next-day associations between SC and WB (Aim 1). To provide a holistic consideration of the three SC facets, we will identify adolescent subgroups based upon their experience of SC quality, quantity, and need (at T1, T3, respectively) and WB trajectories (T1-T2-T3), and examine the prospective transition probabilities between SC constellations and WB trajectories (Aim 2). Lastly, we will assess the convergence of behavioral and neurobiological markers of SC (at T1 and T3) and their prospective associations with WB (Aim 3). Significance: A deeper understanding of the reciprocal relationship between SC and WB and the neurobiological mechanisms underlying these associations will be crucial for mechanism- informed prevention programming.