Mid-Career Mentoring Award For Patient-Oriented Research in Frailty and Health Outcomes

职业生涯中期指导奖,表彰以患者为导向的虚弱和健康结果研究

基本信息

  • 批准号:
    10651807
  • 负责人:
  • 金额:
    $ 17.25万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-07-01 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Increasing evidence suggests that frailty—a common problem of old age characterized by reduced physiologic reserve and inability to tolerate acute stressors—may determine inter-individual variability in outcomes after drug therapy and surgical procedures among older adults. While this understanding supports the idea of personalizing treatments based on a patient's frailty level, there is little empirical evidence on how to use frailty information to maximize benefits or avoid harms in older patients. There is a pressing need to understand how frailty affects the outcomes of various medical and surgical treatments. The candidate is a geriatrician and epidemiologist who has established a robust patient-oriented research program on frailty, geriatric pharmacoepidemiology, and prediction of functional outcomes after surgery at Hebrew SeniorLife Marcus Institute for Aging Research. He is also a dedicated mentor of trainees and junior faculty, who have published a number of peer-reviewed papers and have successfully competed for training and career development awards in aging research. The candidate's research program has a long-term objective to improve care of older adults with frailty by generating high-quality evidence, training future clinicians and researchers, and changing health systems and policy. Toward this goal, his current NIA-funded research focuses on use of a frailty index for Medicare data to determine who should be treated with a drug therapy or a surgical procedure and who should not due to lack of benefit or increased likelihood of harm. This K24 Mid-career Investigator Award proposal will allow the candidate to develop a formal mentoring program, expand his research, and become a more effective mentor and leader. The specific aims are to: 1) develop a mentoring program in frailty research for early-stage and new investigators from diverse clinical and research backgrounds; 2) conduct high-quality research to determine heterogeneity of treatment effects by frailty for a broad range of medical and surgical interventions; and 3) acquire new research skills in implementation science and enhance capacity in mentorship and leadership within and outside geriatrics. The outstanding collaborative environment of Hebrew SeniorLife and other Harvard-affiliated institutions will provide resources (e.g., various data sources, including Medicare data, computing environment, and career development training courses) and support (e.g., data scientists and research methodology experts) needed to accomplish the proposed activities. The advancement of the candidate's mentoring and research program, supported by this K24 award, will foster growth of well-trained clinician investigators in aging research and accelerate adoption of personalized medicine for older adults across medical and surgical specialties based on a patient's frailty level.
项目总结

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Assessment of Frailty Index at 66 Years of Age and Association With Age-Related Diseases, Disability, and Death Over 10 Years in Korea.
  • DOI:
    10.1001/jamanetworkopen.2022.48995
  • 发表时间:
    2023-03-01
  • 期刊:
  • 影响因子:
    13.8
  • 作者:
    Jang, Jieun;Jung, Heewon;Shin, Jaeyong;Kim, Dae Hyun
  • 通讯作者:
    Kim, Dae Hyun
Balancing Benefit and Harm of Intensive Blood Pressure Lowering Based on Individual Outcome Profile Analysis.
基于个体结果分析的强化降压的利弊平衡。
  • DOI:
    10.1016/j.amjmed.2023.09.003
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Shi,SandraM;Gouskova,Natalia;Park,ChanMi;Travison,ThomasG;Wei,Lee-Jen;Kim,DaeHyun
  • 通讯作者:
    Kim,DaeHyun
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Dae Hyun Kim其他文献

Dae Hyun Kim的其他文献

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{{ truncateString('Dae Hyun Kim', 18)}}的其他基金

Mid-Career Mentoring Award For Patient-Oriented Research in Frailty and Health Outcomes
职业生涯中期指导奖,表彰以患者为导向的虚弱和健康结果研究
  • 批准号:
    10448534
  • 财政年份:
    2022
  • 资助金额:
    $ 17.25万
  • 项目类别:
Applications of Claims-Based Frailty Index to Advance Evidence for Frailty-Guided Decision-Making
应用基于索赔的衰弱指数为衰弱指导决策提供证据
  • 批准号:
    10297953
  • 财政年份:
    2021
  • 资助金额:
    $ 17.25万
  • 项目类别:
Applications of Claims-Based Frailty Index to Advance Evidence for Frailty-Guided Decision-Making
应用基于索赔的衰弱指数为衰弱指导决策提供证据
  • 批准号:
    10640938
  • 财政年份:
    2021
  • 资助金额:
    $ 17.25万
  • 项目类别:
Prospective Monitoring of Newly Approved Cardiovascular Drugs in Older Adults with Frailty
新批准的心血管药物对虚弱老年人的前瞻性监测
  • 批准号:
    10338082
  • 财政年份:
    2019
  • 资助金额:
    $ 17.25万
  • 项目类别:
Epidemiology and Risk of Antipsychotic Use in Hospitalized Elderly with Delirium
患有谵妄的住院老年人的流行病学和使用抗精神病药物的风险
  • 批准号:
    9980746
  • 财政年份:
    2018
  • 资助金额:
    $ 17.25万
  • 项目类别:
Development and Validation of a Frailty Index Using Claims Data for Pharmacoepidemiologic Studies in Older Adults
使用老年人药物流行病学研究的索赔数据开发和验证虚弱指数
  • 批准号:
    8966383
  • 财政年份:
    2015
  • 资助金额:
    $ 17.25万
  • 项目类别:

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