The Influence of Spatial Proximity to Sterile Syringe Sources and Secondary Syringe Exchange on HCV Risk Among Rural People Who Inject Drugs

无菌注射器来源的空间接近性和二次注射器交换对农村注射吸毒者 HCV 风险的影响

• 批准号: 10651759
• 负责人: Eric Romo
• 金额: $ 5.02万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-06 至 2024-07-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10651759
• 关键词: Address; Adult; Affect; Behavior; Caring; Communicable Diseases; Communities; Country; County; Cross-Sectional Studies; Data; Development; Disease Outbreaks; Drug user; Economics; Environment; Environmental Risk Factor; Epidemic; Equipment; Future; Geography; HIV; HIV risk; HIV/HCV; Harm Reduction; Hepatitis C; Hepatitis C Incidence; Hepatitis C Transmission; Hepatitis C virus; Indiana; Individual; Infection; Injecting drug user; Injections; Intervention; Interview; Knowledge; Link; Massachusetts; Mediating; Methods; Modeling; Names; Needle Sharing; Needle-Exchange Programs; New England; New Hampshire; Outcome; Participant; Pathway Analysis; Perception; Persons; Pharmaceutical Preparations; Pharmacy facility; Physical environment; Policies; Research; Resource-limited setting; Resources; Risk; Rural; Rural Community; Rural Population; Sales; Services; Social Environment; Social Network; Source; Sterility; Surveys; Syringes; Urban Population; Vermont; Virus; Vulnerable Populations; Work; disease transmission; experience; injection drug use; opioid epidemic; peer; prescription opioid; prevent; rural counties; social; social influence; transmission process; urban setting; virtual

PROJECT SUMMARY / ABSTRACT The current U.S. opioid epidemic has fueled an increase in injection drug use and, in turn, an alarming surge in new hepatitis C virus (HCV) infections. Between 2010 and 2015, the incidence of HCV increased by 294% nationally, driven primarily by a rise in injection drug use and risky injection behavior – namely syringe sharing. This growing epidemic has disproportionately affected young people who inject drugs (PWID) in rural communities. There is an urgent need to implement tailored and effective harm reduction strategies to rural PWID who are disproportionately impacted by HCV. Although research has shown that syringe services and pharmacy syringe sales (i.e sterile syringe sources) are associated with a reduction in injection-mediated risks and HIV transmission, the evidence for whether these services reduce HCV risk among PWID remains mixed. This proposal will applying the risk environment model to evaluate the influence of sterile syringe sources on the HCV risk environment. Specifically, this proposal will evaluate whether spatial proximity to sterile syringe sources and receptive secondary syringe exchange are associated with HCV serostatus among rural PWID. The aims are: (1) To evaluate the association between road network distance to the nearest sterile syringe source (SSP or pharmacy that sells nonprescription syringes) and HCV serostatus; (2) To use egocentric social network analysis to evaluate the association between receptive secondary syringe exchange and HCV serostatus; (3) to explore and unpack rural PWIDs’ perceptions of and experiences with syringe acquisition and syringe sharing practices through in-depth interviews. These findings could help inform the development of future harm reduction interventions in rural New England, a region of the country that has been particularly hard hit by the opioid epidemic and related HCV infections.

项目总结/摘要 目前美国阿片类药物的流行助长了注射毒品使用的增加，反过来， 新的丙型肝炎病毒（HCV）感染2010年至2015年间，HCV的发病率上升了294% 在全国范围内，主要是由于注射毒品使用和危险注射行为的增加-即共用注射器。 这一日益严重的流行病对农村地区注射毒品的年轻人造成了不成比例的影响。 社区.迫切需要对农村地区实施有针对性的有效减少危害战略， PWID受HCV影响不成比例。尽管研究表明，注射器服务和 药房注射器销售（即无菌注射器来源）与注射介导的风险降低相关 和艾滋病毒传播，这些服务是否降低PWID中的HCV风险的证据仍然是混合的。 本提案将应用风险环境模型评价无菌注射器源对 HCV风险环境具体而言，本提案将评价无菌注射器的空间接近度 在农村PWID中，感染源和接受性二次注射器交换与HCV血清状态相关。 研究目的：（1）评价道路网距离与最近无菌注射器的关系 来源（SSP或出售非处方注射器的药房）和HCV血清状态;（2）使用自我中心 社会网络分析，以评估接受性二次注射器交换与HCV之间的关联 （3）探索和揭示农村PWID对注射器获取的看法和经验， 注射器共用的做法。这些发现可以帮助了解 未来在新英格兰农村的减少危害干预措施，该国的一个地区， 受到阿片类药物流行和相关HCV感染的严重打击。

项目成果

Association of spatial proximity to fixed-site syringe services programs with HCV serostatus and injection equipment sharing practices among people who inject drugs in rural New England, United States.

• DOI: 10.1186/s12954-023-00916-5
• 发表时间: 2024-01-28
• 期刊: HARM REDUCTION JOURNAL
• 影响因子: 4.4
• 作者: Romo, Eric;Stopka, Thomas J.;Jesdale, Bill M.;Wang, Bo;Mazor, Kathleen M.;Friedmann, Peter D.
• 通讯作者: Friedmann, Peter D.

HCV serostatus and injection sharing practices among those who obtain syringes from pharmacies and directly and indirectly from syringe services programs in rural New England.

• DOI: 10.1186/s13722-022-00358-7
• 发表时间: 2023-01-03
• 期刊: ADDICTION SCIENCE & CLINICAL PRACTICE
• 影响因子: 3.7
• 作者: Romo, Eric;Rudolph, Abby E.;Stopka, Thomas J.;Wang, Bo;Jesdale, Bill M.;Friedmann, Peter D.
• 通讯作者: Friedmann, Peter D.