Enhanced Stem Cell Therapy with Rehabilitation Strategies for Peripheral Nerve Regeneration
增强干细胞治疗与周围神经再生康复策略
基本信息
- 批准号:10515275
- 负责人:
- 金额:$ 0.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-03-27 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:AccidentsAcuteAdultAnimal ModelBiochemicalBiologicalBiomedical EngineeringBiophysicsBirthBlood VesselsCell CommunicationCell Differentiation processCell Membrane PermeabilityCell SurvivalCellsChildChildhoodCicatrixComplexCoupledCuesDefectDevicesEffectivenessElectric StimulationElectrophysiology (science)EncapsulatedEngineeringEuropeExposure toFosteringGoalsGoldGraft SurvivalHarvestHealthcare SystemsHumanImmuneImmune responseImplantIn VitroInfiltrationInflammatoryInflammatory ResponseInjuryLeftLocationLongevityMediator of activation proteinMembraneMethodsModelingMolecular AnalysisMotor VehiclesMuscleMuscular AtrophyNTF3 geneNatureNerveNerve RegenerationNeuronsNeurotrophin 3Operative Surgical ProceduresOxidative StressPathway interactionsPatientsPeripheral NervesPeripheral nerve injuryPhysical ExercisePhysical RehabilitationPopulationProcessProductionProteinsRattusRecoveryRecovery of FunctionRehabilitation therapyResearchRoleSiliconSiteSpinalSynapsesTNF geneTechniquesTherapeuticTrainingTranslatingTransplantationTraumaWithdrawalWorkbehavior testbioelectricitycell behaviorcombatcostcytokinedrug candidateelectrical potentialexcitotoxicityimprovedin vivoinjury and repairinsightnanoporenerve damagenerve injurynerve repairnerve stem cellnerve supplyneuromuscularneurotrophic factorperipheral nerve regenerationperipheral nerve repairpreventregenerative approachrehabilitation strategyrelating to nervous systemrelease factorrepairedresponsesciatic nervestem cell therapystem cellstherapeutic effectivenesstreatment optimizationtumorvehicular accident
项目摘要
Project Summary
Over 100,000 peripheral nerve injuries (PNI) including motor vehicle and combat
accidents occur annually in the U.S. and Europe. In addition, PNI accounts for nearly one
fourth of the pediatric nerve damage. Common causes in children include direct trauma
related to birth, motor vehicle accidents, as well as tumor, vascular, and compression
injuries. Approximately $150 billion is spent each year because of nerve injury, with 87%
of these costs due to lost production outside of healthcare system. Most patients are left
with lifelong functional deficits, creating a major personal and societal burden. The
current gold standard is to use a patient's own nerves harvested from one location to treat
nerve defects at injury site. However, the drawbacks are significant including the limited
availability of the donor nerve, size of donor nerve, and scarring and complications
occurring at the surgical sites. Recently, human neural stem cells (hNSCs) have emerged
as a potential treatment for neural recovery. However, there is limited graft survival (5-
20%) immediately following transplantation due to acute inflammatory/immune
response and neurotrophic factor withdrawal in the complex microenvironment. This
subsequently diminishes the therapeutic effectiveness of hNSC therapy. It is crucial to
understand how transplanted hNSCs are influenced by their microenvironmental cues to
sustain their viability and elicit the desired cellular behaviors to enhance nerve repair.
Stem cells interact with their microenvironment through biochemical factors,
matrix proteins, and cell-cell interactions. My research focuses on using regenerative
strategies to biophysical, biochemical, and bioelectrical microenvironment to further
enhance the therapeutic potential and sustain the survival of transplanted hNSCs to
repair nerve defects. Specifically, hNSCs will be electrically stimulated and encapsulated
in silicon nanopore membrane (SNM) for enhanced therapeutic effectiveness and survival.
In addition, physical rehabilitation will be implemented to promote nerve recovery. The
goal of this research is to understand biological pathways related to peripheral nerve
repair through biochemical modulation, and electrical and physical rehabilitation to
enhance the therapeutic potential of hNSCs. By understanding the interplay between
stem cells and various forms of rehabilitation strategies, we can investigate new device
approaches and identify essential pathways that can translate into better neural recovery
and nerve regeneration strategies for PNI in humans.
项目摘要
超过10万例周围神经损伤(PNI),包括机动车辆和战斗
美国和欧洲每年都会发生事故。此外,PNI占到近1/3
第四例为儿科神经损伤。儿童的常见原因包括直接创伤
与出生、机动车事故以及肿瘤、血管和压迫有关
受伤。每年约有1500亿美元用于神经损伤,其中87%
其中,这些成本是由于医疗保健系统以外的生产损失造成的。大多数病人都被留了下来
患有终生功能缺陷,造成重大的个人和社会负担。这个
目前的黄金标准是使用从一个位置采集的患者自己的神经来治疗
损伤部位神经缺损处。然而,这些缺点是显著的,包括有限的
供体神经的可用性、供体神经的大小、瘢痕形成和并发症
发生在手术部位。近年来,人类神经干细胞(HNSCs)已经出现。
作为一种潜在的神经恢复治疗方法。然而,移植物存活率有限(5-
20%)移植后立即因急性炎症/免疫
复杂微环境中的反应和神经营养因子撤退。这
从而降低了hNSC治疗的疗效。这是至关重要的
了解移植的hNSCs如何受到其微环境线索的影响
维持它们的生存能力,并诱导所需的细胞行为,以加强神经修复。
干细胞通过生化因素与其微环境相互作用,
基质蛋白和细胞-细胞间的相互作用。我的研究重点是使用再生
生物物理、生化和生物电微环境战略,以进一步
增强移植的hNSCs的治疗潜力并维持其存活
修复神经缺陷。具体地说,将对hNSCs进行电刺激和封装
在硅纳米孔膜(SNM),以提高治疗效果和存活率。
此外,还将实施身体康复,促进神经恢复。这个
本研究的目的是了解与周围神经相关的生物通路。
通过生化调节修复,并通过电和身体康复来
增强hNSCs的治疗潜力。通过了解两者之间的相互作用
干细胞和各种形式的康复策略,我们可以研究新的设备
并确定可转化为更好的神经恢复的基本途径
以及人类PNI的神经再生策略。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Shang Song', 18)}}的其他基金
Enhanced Stem Cell Therapy with Rehabilitation Strategies for Peripheral Nerve Regeneration
增强干细胞治疗与周围神经再生康复策略
- 批准号:
9759498 - 财政年份:2019
- 资助金额:
$ 0.25万 - 项目类别:
Enhanced Stem Cell Therapy with Rehabilitation Strategies for Peripheral Nerve Regeneration
增强干细胞治疗与周围神经再生康复策略
- 批准号:
9922117 - 财政年份:2019
- 资助金额:
$ 0.25万 - 项目类别:
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