Determination of the site of pharyngeal collapse in Obstructive Sleep Apnea patients from snoring sounds

从鼾声判断阻塞性睡眠呼吸暂停患者咽部塌陷部位

• 批准号: 10515474
• 负责人: DAVID ANDREW WELLMAN
• 金额: $ 59.25万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-10 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10515474
• 关键词: Acoustics; Address; Adherence; Algorithms; Clinical; Continuous Positive Airway Pressure; Data; Data Collection; Data Set; Devices; Disease; Drug usage; Early identification; Endoscopy; Epiglottis structure; Explosion; Goals; Grant; Health; Home; Home environment; Hypoglossal nerve structure; Individual; Label; Lateral; Literature; Mandibular Advancement; Measurement; Measures; Methods; Mission; National Heart, Lung, and Blood Institute; Obstruction; Obstructive Sleep Apnea; Operative Surgical Procedures; Oropharyngeal; Otolaryngologist; Outcome; Patient Selection; Patients; Persons; Pharmaceutical Preparations; Pharyngeal structure; Problem Solving; Procedures; Progress Reports; Public Health; Reproducibility; Research; Shapes; Signal Transduction; Site; Sleep; Sleep Disorders; Snoring; Structure; Testing; Therapeutic; United States National Institutes of Health; Work; base; clinical practice; cost; effective therapy; experimental study; improved; predictive modeling; public repository; sound; tongue root

ABSTRACT Obstructive Sleep Apnea (OSA) is a prevalent disorder that remains undertreated due to poor adherence with continuous positive airway pressure (CPAP). Several studies suggest that the pharyngeal airway can collapse at different sites in patients with OSA (velum, oropharyngeal lateral walls, tongue base, and/or epiglottis). Furthermore, many of the non-CPAP treatments for OSA have been shown to work better for some sites of collapse than others. The problem is, the site of collapse requires expensive or invasive procedures, such as drug-induced sleep endoscopy (DISE). This proposal seeks to solve that problem by determining the site of collapse from acoustic analysis of snoring sounds. In Aim 1, a model for predicting the site of collapse will be developed using DISE with simultaneously measured snoring sounds in 800 individuals. In Aim 2, natural sleep endoscopy will be performed in a subset of people from Aim 1 to confirm that the collapsing structure(s) produce the same sound in natural sleep as drug-induced sleep. Finally, Aim 3 will test the ability to measure snoring sounds in the home environment. Comparisons will be made between snores from natural sleep endoscopy and natural sleep at home (in the same individual). Additionally, snoring will be measured at home on separate nights to test reproducibility across nights. The studies in this grant are expected to produce an algorithm for estimating the site of pharyngeal collapse from snoring sounds. This algorithm could improve the selection of patients for non-CPAP therapies and potentially increase the number of patients effectively treated for OSA.

摘要