The impact of social isolation on aging health in schizophrenia
社会隔离对精神分裂症老年健康的影响
基本信息
- 批准号:10522303
- 负责人:
- 金额:$ 76.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-15 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:AgeAge-YearsAgingAntipsychotic AgentsBehaviorBiological MarkersBody mass indexCOVID-19COVID-19 pandemicCharacteristicsClinicalCognitionCountryDataDepressed moodDiagnosisDietDiseaseEthnic OriginEthnic groupEuropeExhibitsGeneral PopulationGoalsGovernmentHealthIndividualInstitutesLifeLonelinessLongevityMeasuresMedicalMedical RecordsMental DepressionNatural experimentOutcomeParticipantPatientsPatternPhenotypePhysiciansPremature MortalityPreventiveProcessPsychotic DisordersRaceResearchResourcesRiskRisk FactorsSchizophreniaSeverity of illnessSiblingsSmokeSmokingSocial NetworkSocial isolationSocializationStressSubgroupSymptomsTestingTimeUnhealthy DietVulnerable PopulationsWorkage relatedcohortcomorbiditycoronavirus diseasedesigndigitalfollow-uphealth datahealth differencehuman old age (65+)longitudinal databaselongitudinal designmiddle agemortalityneuropsychiatrypandemic diseasephysical conditioningphysical inactivityprematurepreventracial and ethnicsecondary analysissexsocial contactsymptomatologytargeted treatmentunhealthy lifestyle
项目摘要
PROJECT SUMMARY
Individuals diagnosed with schizophrenia and related psychotic disorders (SZ) exhibit a markedly elevated risk
of premature mortality, with a 10–20-year shorter lifespan relative to the general population. Increased mortality
rates in SZ are largely attributable to the early manifestation of medical conditions that normally occur later in
life, a process known as ‘accelerated aging’. While unhealthy lifestyle behaviors, such as smoking and unhealthy
diet, account, in part, for accelerated aging in SZ, the excess of physical comorbidities cannot be solely attributed
to these factors. Remarkably, the direct adverse health effects of key clinical characteristics of SZ have rarely
been considered. In the general population, the absence of social contact is known to pose enormous challenges
for physical health, especially at older ages. Given that social isolation is a persistent and disabling feature of
SZ, it is possible that this behavior may contribute to the premature manifestation of health conditions in SZ.
Building on rich pilot data pointing to significant associations between social isolation and long-term perceived
health in SZ, our overarching goal is to test whether and how social isolation contributes to the health
challenges of individuals with SZ as they age. With participants from Europe (EU-GEI) and the US (Olin
Neuropsychiatry Research Center), we will create a longitudinal database of 650 participants, including 500
individuals with SZ, and 150 of their unaffected siblings. We will apply an accelerated longitudinal design by re-
assessing and by examining medical records of research participants who were first evaluated between the
ages of 30-50 and are now 50-65 years of age, a period when many medical conditions and health problems
tend to manifest. We will determine the age-related association between social isolation and adverse health
outcomes in SZ, test for familiality, directionality, and factors moderating this association, and determine the
extent to which the COVID-19 pandemic and the resulting imposed lockdowns impacted health in SZ. We will
consider generalizability across countries, sexes, and race/ethnicities. The rationale for the proposed research
is that in order to facilitate much-needed targeted therapies to prevent early mortality in SZ, we need to better
understand factors that contribute to the excess of medical comorbidities in SZ. Our central hypothesis is that
social isolation, a common and persistent characteristic of SZ, contributes to the excess of physical
comorbidities in SZ. To meet our overall goal, we will pursue the following aims: (1) Determine the association
between social isolation and adverse health outcomes in SZ; (2) Test for the directionality, and moderating
factors, of the association between social isolation and health outcomes in SZ, and; (3) Examine whether the
COVID-19 pandemic modified associations between social isolation and health outcome in SZ. This study will
be the first to comprehensively examine the health impact of social isolation in SZ. The project may show that
in SZ socialization in midlife can reduce the risk for poor health outcomes and ultimately facilitate much-needed
preventive targeted therapies to reduce early-age mortality in SZ.
项目总结
被诊断为精神分裂症和相关精神障碍(SZ)的个体的风险显著增加
与一般人口相比,过早死亡的寿命短10-20年。死亡率上升
深圳的发病率很大程度上归因于通常发生在#年后期的医疗状况的早期表现。
生命,一个被称为“加速衰老”的过程。而不健康的生活方式行为,如吸烟和不健康
饮食在一定程度上是深圳加速衰老的原因,不能完全归因于身体合并症的过度
这些因素。值得注意的是,SZ的主要临床特征对健康的直接不利影响很少
被考虑过了。众所周知,在普通人群中,缺乏社会联系会带来巨大的挑战。
对于身体健康,特别是在较年长的年龄。鉴于社交孤立是一种持久且令人无法接受的特征
SZ,这一行为可能是导致SZ健康状况过早显现的原因之一。
建立在丰富的试点数据基础上,指出社会孤立和长期感知之间的显著关联
在深圳的健康,我们的首要目标是测试社会孤立是否以及如何有助于健康
随着年龄的增长,SZ患者面临的挑战。参与者来自欧洲(EU-GEI)和美国(OLINE
神经精神病学研究中心),我们将创建包含650名参与者的纵向数据库,其中包括500名参与者
患有SZ的个人及其150名未受影响的兄弟姐妹。我们将通过重新设计来应用加速纵向设计
评估并通过检查研究参与者的医疗记录,这些参与者在
30-50岁,现在50-65岁,这是一个许多疾病和健康问题的时期
倾向于显露。我们将确定与年龄相关的社交隔离和不良健康之间的联系
在SZ的结果,测试熟悉度、方向性和调节这种联系的因素,并确定
新冠肺炎疫情和随之而来的封锁对深圳健康的影响程度。我们会
考虑跨国家、性别和种族/民族的概括性。建议进行这项研究的理由
是为了促进急需的靶向治疗以防止深圳的早期死亡,我们需要更好地
了解导致深圳医疗合并症过多的因素。我们的中心假设是
社交隔离是深圳常见且持久的特征,也是导致身体过度紧张的原因之一
深圳的合并症。为实现总体目标,我们将追求以下目标:(1)确定协会
社会隔离与深圳地区不良健康后果之间的关系;(2)定向测验和调节
在深圳,社会隔离与健康结果之间的联系;以及;。(3)研究
在深圳,新冠肺炎大流行改变了社会隔离与健康结果之间的关联。这项研究将
在深圳率先全面考察社会隔离对健康的影响。该项目可能会显示出
在深圳,中年的社会化可以降低健康状况不佳的风险,并最终促进急需的
预防性靶向治疗以降低深圳的早期死亡率。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ABRAHAM REICHENBERG其他文献
ABRAHAM REICHENBERG的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ABRAHAM REICHENBERG', 18)}}的其他基金
The impact of social isolation on aging health in schizophrenia
社会隔离对精神分裂症老年健康的影响
- 批准号:
10680522 - 财政年份:2022
- 资助金额:
$ 76.41万 - 项目类别:
Autism and Prenatal Endocrine Disruptors (A-PED)
自闭症和产前内分泌干扰物 (A-PED)
- 批准号:
10251532 - 财政年份:2021
- 资助金额:
$ 76.41万 - 项目类别:
Autism Risk and Maternal Cardiometabolic Health (ARCH) study
自闭症风险与母亲心脏代谢健康 (ARCH) 研究
- 批准号:
10674627 - 财政年份:2019
- 资助金额:
$ 76.41万 - 项目类别:
Autism Risk and Maternal Cardiometabolic Health (ARCH) study
自闭症风险与母亲心脏代谢健康 (ARCH) 研究
- 批准号:
10443600 - 财政年份:2019
- 资助金额:
$ 76.41万 - 项目类别:
Autism Risk and Maternal Cardiometabolic Health (ARCH) study
自闭症风险与母亲心脏代谢健康 (ARCH) 研究
- 批准号:
10178066 - 财政年份:2019
- 资助金额:
$ 76.41万 - 项目类别:
Autism and Prenatal Endocrine Disruptors (A-PED)
自闭症和产前内分泌干扰物 (A-PED)
- 批准号:
9349499 - 财政年份:2016
- 资助金额:
$ 76.41万 - 项目类别:
Autism and Prenatal Endocrine Disruptors (A-PED)
自闭症和产前内分泌干扰物 (A-PED)
- 批准号:
9133065 - 财政年份:2016
- 资助金额:
$ 76.41万 - 项目类别:
Autism and Prenatal Endocrine Disruptors (A-PED)
自闭症和产前内分泌干扰物 (A-PED)
- 批准号:
10006730 - 财政年份:2016
- 资助金额:
$ 76.41万 - 项目类别:
Multigenerational FamIlial and Environmental Risk for Autism (MINERvA) Network
自闭症多代家庭和环境风险 (MINERvA) 网络
- 批准号:
9121391 - 财政年份:2012
- 资助金额:
$ 76.41万 - 项目类别:
Multigenerational FamIlial and Environmental Risk for Autism (MINERvA) Network
自闭症多代家庭和环境风险 (MINERvA) 网络
- 批准号:
8537788 - 财政年份:2012
- 资助金额:
$ 76.41万 - 项目类别:
相似海外基金
PREDICTING CARIES RISK IN UNDERSERVED CHILDREN, FROM TODDLERS TO THE SCHOOL-AGE YEARS, IN PRIMARY HEALTHCARE SETTINGS
预测初级医疗保健机构中从幼儿到学龄儿童的龋齿风险
- 批准号:
10361268 - 财政年份:2021
- 资助金额:
$ 76.41万 - 项目类别:
Predicting Caries Risk in Underserved Children, from Toddlers to the School-Age Years, in Primary Healthcare Settings
预测初级医疗机构中服务不足的儿童(从幼儿到学龄儿童)的龋齿风险
- 批准号:
9751077 - 财政年份:2011
- 资助金额:
$ 76.41万 - 项目类别:
Predicting Caries Risk in Underserved Children, from Toddlers to the School-Age Years, in Primary Healthcare Settings
预测初级医疗机构中服务不足的儿童(从幼儿到学龄儿童)的龋齿风险
- 批准号:
9976990 - 财政年份:2011
- 资助金额:
$ 76.41万 - 项目类别:
Predicting Caries Risk in Underserved Children, from Toddlers to the School-Age Years, in Primary Healthcare Settings
预测初级医疗机构中服务不足的儿童(从幼儿到学龄儿童)的龋齿风险
- 批准号:
10457019 - 财政年份:2011
- 资助金额:
$ 76.41万 - 项目类别:
Predicting Caries Risk in Underserved Children, from Toddlers to the School-Age Years, in Primary Healthcare Settings
预测初级医疗机构中服务不足的儿童(从幼儿到学龄儿童)的龋齿风险
- 批准号:
10213006 - 财政年份:2011
- 资助金额:
$ 76.41万 - 项目类别:














{{item.name}}会员




