Telehealth Parent-Only Treatment for Youth with Autism Spectrum Disorder and Overweight/Obesity

为患有自闭症谱系障碍和超重/肥胖的青少年提供仅限家长的远程医疗治疗

• 批准号: 10521960
• 负责人: Kerri N Boutelle
• 金额: $ 67.89万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10521960
• 关键词: Adaptive Behaviors; Adolescent; Adult; Affect; Aftercare; Age; Behavior; Behavior Therapy; Body Size; Body Weight decreased; Body mass index; Child; Child Rearing; Childhood; Clinical; Consumption; Control Groups; Data; Development; Diagnosis; Dietary intake; Educational Status; Family; Gender; Goals; Health; Health Personnel; Health education; Height; Heterogeneity; High Prevalence; Intervention; Language; Mediator of activation protein; Modeling; Obesity; Outcome; Overweight; Parents; Physical activity; Pilot Projects; Play; Population; Public Health; Randomized; Reporting; Research; Research Personnel; Role; Self Efficacy; Severities; Symptoms; Time; United States; Vegetables; Vulnerable Populations; Weight; Weight Gain; Youth; active comparator; adolescent with autism spectrum disorder; autism spectrum disorder; autistic children; base; comparative efficacy; cost; effective therapy; efficacious intervention; executive function; follow-up; individualized medicine; intervention cost; intervention program; obesity in children; pilot test; programs; psychosocial; randomized trial; recruit; satisfaction; skills; telehealth; treatment group; treatment program; treatment response; weight loss program

ABSTRACT Approximately 1 in 54 children in the United States is diagnosed with autism spectrum disorder (ASD). Among children with ASD, estimates of overweight and obesity (OW/OB) range from 19% to as high as 55% with the majority of studies reporting OW/OB rates equal to or greater than typically developing children. OW/OB in childhood tracks well into adulthood and is associated with negative health and psychosocial consequences. To date, the most successful treatment for typically developing children with OW/OB is family-based behavioral treatment (FBT), which delivers weekly group-based treatment to the parent and child separately over a 6- month period. However, children with ASD are typically excluded from these trials and given their unique presentation, require a tailored treatment program. FBT programs for parents without their child (Parent-based treatment [PBT]) are more appropriate for families with a child with ASD and OW/OB, as the functioning and language levels of the children can impact their ability to directly participate in an intensive group-based program. Research shows that PBT is noninferior to FBT on child weight loss and is less costly to implement. Our group has developed and pilot tested a PBT group for children with ASD and OW/OB (called PBT-ASD). Our pilot data showed that the PBT-ASD program was feasible, acceptable and showed initial efficacy on child weight loss. This project is the next step in this program of research, and we will recruit 150 youth with OW/OB and ASD and their parent and randomize them to a 6-month telehealth PBT-ASD or active health education comparator (HE). We will assess main outcomes in children and parents at five time points; baseline, mid- treatment (month 3), post-treatment (month 6), 6-month follow-up (month 12) and 12-month follow-up (month 18). The primary aim of this study is to compare the effect of PBT-ASD and HE on the target child’s weight (BMIz/%BMIp95) over the 18 months of the study. The secondary aim is to determine the extent to which the PBT-ASD and HE affect parent BMI, parent and child physical activity and dietary intake, child mealtime behavior, parenting style and self-efficacy. As an exploratory aim, we will evaluate moderators (e.g. parent and child gender, parent and child age, parent educational level, parent baseline BMI, child baseline BMIz/%BMI p95, parent executive functioning, parenting, child symptom severity, child adaptive behavior skills) and mediators (e.g. parenting, child symptom severity) of the PBT-ASD and the HE treatment on child BMIz/%BMI p95 over time. This program of research could advance the standard of practice for children with ASD, and could result in a tailored intervention for children with both ASD and OW/OB. We believe that by working with parents using a telehealth model, we can potentially provide an effective and durable treatment, which can easily be disseminated to parents with children with both ASD and OW/OB.

摘要