Achieving Targeted Delivery of Drugs to Uterine Muscle in Women for the Prevention of Preterm Labour

实现将药物靶向输送至女性子宫肌以预防早产

• 批准号: nhmrc : GNT1113847
• 负责人: A/Pr Kristina Adams Waldorf
• 金额: $ 46.9万
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/achieving-targeted-delivery-preterm-labour/1346876
• 关键词: Achieving; Targeted; Delivery; Drugs; Uterine

We have patented liposomes targeted to the uterus, which enable us to deliver drugs specifically to the muscle cells of the uterus, increasing safety. The liposomes can be loaded with drugs that either block or promote contractions, creating a versatile drug delivery system that could treat premature labour or postpartum haemorrhage which are major clinical problems. We seek support to demonstrate their effectiveness in mouse and primate models of preterm labour prior to human studies.

我们有针对子宫的专利脂质体，这使我们能够将药物专门输送到子宫的肌肉细胞，提高安全性。脂质体可以装载阻断或促进子宫收缩的药物，形成一种多功能的药物输送系统，可以治疗早产或产后出血等主要临床问题。我们寻求支持，以证明其有效性在小鼠和灵长类动物的早产模型在人类研究之前。