Functional and Radiomic Magnetic Resonance Profiling in Normal and Hypertensive Placentas

正常和高血压胎盘的功能和放射磁共振分析

• 批准号: 10525117
• 负责人: Christina Lynn Herrera
• 金额: $ 14.07万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-02 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10525117
• 关键词: Address; Affect; Area; Arteries; Award; Basic Science; Biological Markers; Blood Vessels; Characteristics; Chronic; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Data; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Doppler Ultrasound; Early identification; Fetal Growth Retardation; Fetal health; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Grant; Growth; Heterogeneity; Human; Hypertension; Image; Interdisciplinary Study; Intervention; K-Series Research Career Programs; Knowledge; Magnetic Resonance; Magnetic Resonance Imaging; Manuals; Maps; Maternal Health; Measurement; Measures; Mediating; Mentors; Motion; Outcome; Pathologic; Pathology; Pattern; Peer Review; Perfusion; Placenta; Placenta Diseases; Placentation; Populations at Risk; Pre-Eclampsia; Pregnancy; Pregnant Women; Process; Publications; Reproducibility; Reproducibility of Results; Research; Research Personnel; Resistance; Risk; Role; Second Pregnancy Trimester; Spiral Artery of the Endometrium; Standardization; T2 weighted imaging; Technical Expertise; Techniques; Technology; Testing; Texture; Time; Translational Research; Uterus; Woman; Work; arterial spin labeling; automated segmentation; base; blood oxygen level dependent; career; clinical investigation; cohort; contrast imaging; deep learning; faculty mentor; hypertensive; hypoperfusion; imaging Segmentation; imaging modality; improved; in vivo; insight; interest; non-invasive imaging; novel; predictive modeling; pregnant; prenatal exposure; prospective; protein biomarkers; radiomics; skills; ultrasound

PROJECT SUMMARY One in 3 pregnant women with chronic hypertension (CHTN) deliver preterm from complications of superimposed preeclampsia or fetal growth restriction (FGR). The specific aims are: 1) prospectively evaluate the placental longitudinally via functional magnetic resonance imaging (MRI) in healthy pregnant women and pregnant women with CHTN; 2) extract radiomics texture features in normal and hypertensive placentas and 3) execute technical refinement toward automated segmentation for regions of interest to delineate patterns in placental abnormalities. We will study 20 normal pregnant women and 40 pregnant women with CHTN across gestation. MRI will be performed in the early and late second trimester to assess perfusion via arterial spin labeling (ASL), diffusion via intra-voxel incoherent motion (IVIM) diffusion weighted imaging (DWI) and DWI- derived apparent diffusion coefficient (ADC) mapping, and oxygenation via T2* from blood-oxygen level dependent (BOLD) MRI. Radiomics texture features also be extracted from MR imaging and automated segmentation applied for more subjective placental assessment. This career development award will establish Dr. Herrera as a clinical investigator focused on non-invasive imaging assessment of placental development and dysfunction. The award will provide her with the support needed to develop expertise in 3 areas: 1) clinical research 2) application and interpretation of advanced imaging modalities, and 3) technical skills of post- processing and deep learning. To achieve these goals, Dr. Herrera has assembled an interdisciplinary team with expertise in clinical investigation, placental imaging, and post-processing and automated segmentation techniques. Her primary mentor, Dr. Catherine Spong, has a long track record of successful clinical, translational, and basic science research including over 270 peer review publications and mentoring faculty to become independent investigators. The focus of this proposal is on the human placenta. Despite 150+ years of placental research, the role of the placenta in the pathology of pregnancy-related disease remains poorly understood. Understanding normal placental development and changes present in placental disease will provide a foundation to facilitate clinical prediction of pathologic conditions during pregnancy and provide an opportunity to test interventions. In this study, we will address the unmet clinical need to characterize both normal placental development and placental dysfunction in vivo. We have chosen to compare normal pregnant women with pregnant women with chronic hypertension as these women are increased risk for placental- mediated disease. Successful completion of this project will allow for better understanding of the placenta in normal pregnancy and pregnancy affected by chronic hypertension. We will also correlate our results with clinical outcomes of preeclampsia and FGR. Given the increased risk of superimposed preeclampsia and FGR in pregnant women with chronic hypertension, we anticipate from these results additional insights and novel hypotheses regarding potential radiomic biomarkers for the prediction of preeclampsia and FGR.

项目总结 每3名患有慢性高血压(CHTN)的孕妇中就有1人因以下并发症而早产 叠加子痫前期或胎儿生长受限(FGR)。具体目标是：1)前瞻性评价 功能磁共振成像(MRI)对健康孕妇胎盘的纵向研究 2)提取正常胎盘和高血压胎盘的放射组学纹理特征；3) 对感兴趣的区域执行自动分割的技术改进，以在 胎盘异常。我们将研究20名正常孕妇和40名患有CHTN的孕妇。 怀孕了。将在妊娠早期和中期进行核磁共振检查，以评估通过动脉脊椎的血流灌注。 标记(ASL)、体素内非相干运动扩散(IVIM)、扩散加权成像(DWI)和DWI- 导出表观扩散系数(ADC)图，并通过T2*从血氧水平进行氧合 依赖的(大胆的)核磁共振。放射组学纹理特征也可以从MR成像中提取并自动进行 分割适用于更主观的胎盘评估。这个职业发展奖将设立 Herrera博士是一名临床研究员，专注于胎盘发育的非侵入性成像评估 和功能障碍。该奖项将为她提供在3个领域发展专业知识所需的支持：1)临床 研究2)先进成像模式的应用和解释，以及3)后处理的技术技能 处理和深度学习。为了实现这些目标，埃雷拉博士组建了一个跨学科的团队 具有临床研究、胎盘成像、后处理和自动分割方面的专业知识 技巧。她的主要导师凯瑟琳·斯彭博士在临床上有着长期的成功记录， 翻译和基础科学研究，包括270多本同行评议出版物和指导教师 成为独立的调查人员。这项提案的重点是人类胎盘。尽管150多年来 胎盘研究，胎盘在妊娠相关疾病的病理中的作用仍然很差 明白了。了解正常的胎盘发育和胎盘疾病的变化将 为临床预测妊娠期间的病理状态提供基础，并提供 测试干预措施的机会。在这项研究中，我们将解决尚未满足的临床需求，以确定两者的特征 体内胎盘发育正常和胎盘功能障碍。我们选择比较正常的怀孕 孕妇患有慢性高血压，因为这些妇女患胎盘的风险增加- 媒介疾病。这个项目的成功完成将使我们能够更好地了解 正常妊娠和妊娠受慢性高血压影响。我们还将把我们的结果与 子痫前期和FGR的临床结局。考虑到叠加先兆子痫和FGR的风险增加 在患有慢性高血压的孕妇中，我们期待从这些结果中获得更多的见解和新的东西。 关于预测子痫前期和FGR的潜在放射组学生物标志物的假设。