Use of Novel Multi-modality Imaging to Evaluate the Relationship Between Sleep Duration, Vascular Inflammation, and Visceral Adiposity
使用新型多模态成像评估睡眠持续时间、血管炎症和内脏肥胖之间的关系
基本信息
- 批准号:10525076
- 负责人:
- 金额:$ 19.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AbdomenAcademyAdipose tissueAdultAgeAmericanAmerican Heart AssociationAtherosclerosisAwardBiological MarkersBloodBlood VesselsBody mass indexCardiometabolic DiseaseCardiovascular DiseasesCardiovascular systemCarotid ArteriesChestChronicClinicClinicalClinical ResearchClinical TrialsCollaborationsCollectionDevelopmentDevelopment PlansDiagnosisDoctor of PhilosophyEnvironmentEpidemicEventFacultyFoundationsFundingFutureGoalsGrantHealthHomeHourHybridsImageInflammationInflammatoryInterdisciplinary StudyInternal MedicineInvestigationK-Series Research Career ProgramsLinkMagnetic Resonance ImagingMeasurementMeasuresMediatingMedicineMentorsMetabolicMulti-Ethnic Study of AtherosclerosisMultimodal ImagingMyocardial InfarctionNeckObesityObservational StudyObstructive Sleep ApneaOutcomePET/CT scanPathway interactionsPatient RecruitmentsPatient Self-ReportPatientsPilot ProjectsPopulationPositron-Emission TomographyPrevention strategyRaceReproducibilityResearchResearch DesignResearch PersonnelResidual stateRisk FactorsRoleScienceSleepSleep DeprivationSleep disturbancesSolidSpecimenStandardizationStrokeSystems BiologyTestingTherapeutic InterventionThoracic aortaTimeTrainingVisceralactigraphybasebiobankbiomarker identificationbody systemcardiometabolic riskcardiometabolismcardiovascular disorder riskcardiovascular imagingcardiovascular risk factorcareercareer developmentcohortdesigndisorder riskearly detection biomarkersepidemiology studyexperiencefluorodeoxyglucosefluorodeoxyglucose positron emission tomographyimaging biomarkerindexinginflammatory markerinsightmedical schoolsmodifiable riskmultidisciplinarymultimodalitynovelnovel markerpatient oriented researchpatient subsetsprognostic indicatorrecruitsexsleep onsetsleep patternsleep physiologysuccesssystemic inflammatory responsetargeted treatmenttrenduptakevascular inflammation
项目摘要
ABSTRACT
The proposed training grant is designed to advance the academic career of Dr. Vaishnavi Kundel, MD, by
building upon her strong background in clinical sleep medicine to engage in patient-oriented research, and
develop expertise in exploring the role of sleep in cardiometabolic disease risk. Through this proposal, she will
obtain multidisciplinary training to investigate chronic sleep deprivation and sleep irregularity as potentially
modifiable risk factors for atherosclerosis and visceral adiposity measured using multi-modality imaging - hybrid
18fluorodeoxyglucose (FDG) PET/MRI. Research plan: The proposed research builds on Dr. Kundel's pilot
studies funded by the AASM. The aims are to determine whether habitual short sleep duration and sleep
irregularity are associated with increased vascular inflammation and visceral adiposity (which is strongly linked
to increased CVD risk), independent of OSA (often a confounder in these associations). We will utilize multi-day
actigraphy to collect objective sleep metrics, and PET/MRI to measure vascular inflammation and visceral
adipose tissue (VAT) metabolic activity (a novel marker of adipose tissue inflammation) in the recruited patients.
With successful completion of the proposed training and research, we hope to underscore the role of chronic
sleep deprivation and sleep irregularity in cardiometabolic risk, establishing an index of imaging biomarkers for
future research. Moreover, the results will provide direction for future (R01) proposals - laying the groundwork
for developing multidisciplinary collaborations to elucidate mechanisms by which sleep modulates inflammation,
with a long-term goal of identifying biomarkers of early cardiovascular risk in this subset of patients, and
designing sleep extension studies. Career Development: Dr. Kundel's training plan features an outstanding
research environment at the Icahn School of Medicine at Mount Sinai along with nationally renowned mentors
and advisors with complimentary expertise. Her primary mentoring team comprises of (a) Dr. Neomi Shah, MD,
MPH, MS (expert in obstructive sleep apnea [OSA] and cardiovascular (CV) diseases, and application of
advanced cardiovascular imaging in OSA) (b) Dr. Indu Ayappa, PhD, (recipient of a mentored K-24 award, with
expertise in OSA, sleep physiology, and use of actigraphy for objective sleep assessments) (c) Drs. Zahi Fayad
and Philip Robson, PhD (experts in use of multimodality imaging for assessment of atherosclerosis and organ
system biology). Her training features a combination of carefully designed coursework and practical experiences
in 1) actigraphy for comprehensive assessments of objective sleep metrics 2) multi-modality cardiometabolic
imaging 3) clinical study design and patient-oriented research 4) training in biomarker science for future
proposals. Together, her mentors and advisors have a successful track record of mentoring junior faculty in
career development awards, with extensive collaborations and grant portfolios to provide a solid foundation for
Dr. Kundel's present proposal, and ultimate success in developing into an independent investigator.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vaishnavi Kundel其他文献
Vaishnavi Kundel的其他文献
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{{ truncateString('Vaishnavi Kundel', 18)}}的其他基金
Use of Novel Multi-modality Imaging to Evaluate the Relationship Between Sleep Duration, Vascular Inflammation, and Visceral Adiposity
使用新型多模态成像评估睡眠持续时间、血管炎症和内脏肥胖之间的关系
- 批准号:
10687854 - 财政年份:2022
- 资助金额:
$ 19.12万 - 项目类别:
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