Improving Overactive Bladder Treatment Access and Adherence Through Personalized Behavioral Modifications and Mobile Technology-Based Interventions

项目概要/摘要 关于OAB慢性病、预期结果、成本和费用的获取机会较差且患者教育不足 潜在的副作用导致患者对治疗的不切实际的感觉和次优的治疗持续时间， 特别是在弱势群体中。因此，这导致不良的治疗可及性、依从性， 治疗不足我的长期目标是发展成为一个独立资助的研究者和国际 领导者将率先采取干预措施，改善OAB治疗的可及性、依从性和结局，从而 减轻这种慢性疾病的负担。本K23提案的总体目标是设计一个 一种创新的、知情的战略，其中包括治疗障碍（如社会决定因素 健康），并改善患者获得治疗选择和治疗依从性。核心假设是 由于缺乏访问和次优的提供者对患者的OAB， 医疗保健提供是治疗依从性障碍。这一中心假设将被测试追求两个 具体目标：1.评估一个适应用户界面的移动的健康工具，用于不同的、多文化的人群， OAB妇女，并确定障碍和促进因素，以获得，治疗依从性和参与， 多个关键利益攸关方。2.进行试点研究，以评估使用移动的 健康工具，以改善OAB知识，参与和治疗计划的遵守，在不同的群体， 女性OAB拟议研究的理由是，预计研究完成后将提供一个强有力的 以证据为基础的框架，以继续制定和今后实施具有成本效益、 循证干预措施，以改善OAB治疗的可及性和依从性。综合这些结果， 我希望通过让我提交一份有竞争力的R01申请， 提出一项随机对照疗效试验，以改善治疗的可及性、依从性和OAB结局 在这个奖项的第四年。

PROJECT SUMMARY/ABSTRACT Poor access and insufficient patient education regarding OAB chronicity, expected outcomes, costs, and potential side effects lead to unrealistic patient perceptions about therapy and suboptimal therapy duration, particularly in vulnerable populations. This thus leads to poor treatment access, adherence, and undertreatment. My long-term goal is to develop as an independently funded investigator and international leader who will pioneer interventions that improve OAB therapy access, adherence and outcomes, thereby reducing the burden of this chronic condition. The overall objective for this K23 proposal is to design an innovative, stakeholder-informed strategy that incorporates barriers to treatment (such as social determinants of health) and improves patient access to therapy options and therapy adherence. The central hypothesis is that unmet patient expectations and knowledge due to lack of access and suboptimal provider-to-patient OAB healthcare delivery are a barrier to treatment adherence. This central hypothesis will be tested pursuing two specific aims: 1. Evaluate an adapted UI mobile health tool for use in a diverse, multicultural population of women with OAB and identify barriers and facilitators to access, treatment adherence and engagement from multiple key stakeholders. 2. Conduct a pilot study to evaluate the usability and feasibility of using a mobile health tool to improve OAB knowledge, engagement and treatment plan adherence in a diverse group of women with OAB. The rationale for the proposed research is that its completion is expected to provide a strong evidence-based framework for the continued development and future implementation of cost-effective, evidence-based interventions to improve OAB therapy access and adherence. Combined these results are expected to have an important positive impact by positioning me to submit a competitive R01 application proposing a randomized controlled efficacy trial for improving therapy access, adherence, and OAB outcomes during the fourth year of this award.