Acupuncture for Cognitive Health in Older Survivors of Prostate Cancer (ACHIEVE)

针灸促进老年前列腺癌幸存者的认知健康 (ACHIEVE)

• 批准号: 10524908
• 负责人: Kevin T Liou
• 金额: $ 24.9万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10524908
• 关键词: Acupuncture Therapy; Address; Advanced Malignant Neoplasm; Affect; Aging; American Cancer Society; Anxiety; Applications Grants; Attention; Award; Biometry; Breast Cancer Patient; Cancer Etiology; Cancer Model; Cancer Survivor; Cancer Survivorship; Caring; Chinese Traditional Medicine; Clinical Trials Design; Cognitive; Cognitive Therapy; Competence; Cross-Sectional Studies; Data; Educational workshop; Elderly; Enrollment; Evaluation; Evidence based treatment; Fatigue; Fibrinogen; Foundations; Functional disorder; Goals; Grant; Guidelines; Health; Impaired cognition; Impairment; Institutional support resources; Integrative Medicine; Integrative Therapy; International; Intervention; K-Series Research Career Programs; Lead; Learning; Literature; Malignant Neoplasms; Malignant neoplasm of prostate; Manuscripts; Medicine; Memorial Sloan-Kettering Cancer Center; Memory; Mental Depression; Mentors; Mentorship; Neurocognitive; Neuropsychology; Nocturia; Older Population; Oncology; Outcome; Personal Satisfaction; Pharmaceutical Preparations; Play; Population; Positioning Attribute; Preparation; Prostate Cancer therapy; Public Health; Quality of life; Randomized; Randomized Controlled Trials; Recording of previous events; Research; Research Personnel; Resources; Role; Scientific Advances and Accomplishments; Sleeplessness; Societies; Subgroup; Survivors; Symptoms; Testing; Toxic effect; Training; United States; Verbal Learning; Waiting Lists; Work; Writing; aging population; androgen deprivation therapy; associated symptom; base; cancer therapy; cancer type; cancer-related cognitive impairment; career development; cognitive function; design; efficacy testing; epidemiology study; executive function; functional independence; health management; improved; instrument; neurotoxic; novel; novel therapeutics; post intervention; preservation; primary outcome; programs; prostate cancer survivors; randomized trial; skills; sociodemographics; symposium; symptom management; symptom science; therapy development; treatment as usual; urinary

PROJECT SUMMARY This career development award, Acupuncture for Cognitive Health in Older Survivors of Prostate Cancer (ACHIEVE), will train Dr. Liou to become an independent clinician-investigator with expertise in integrative therapies for cognitive health and symptom management in prostate cancer (PC) survivors. BACKGROUND: By 2030, PC survivors are expected to become the largest group of cancer survivors in the United States. Cancer-related cognitive dysfunction (CRCD) is a significant concern in this growing population, but evidence- based treatments are lacking. Most CRCD studies in PC have focused on the neuro-toxicities of androgen deprivation therapy (ADT). However, the literature on the association between ADT and CRCD remains mixed, suggesting other factors may play a role in CRCD. Growing research from other populations demonstrates that co-morbid symptoms (anxiety, depression, fatigue, insomnia, nocturia) may contribute to cognitive dysfunction. These symptoms are prevalent among PC survivors, but their role in CRCD remains poorly understood in the PC population. Expanding CRCD research beyond the non-modifiable factors (prior ADT exposure) and focusing on modifiable factors (co-morbid symptoms) has the potential to inform novel treatments approaches for CRCD. Based on Dr. Liou’s preliminary studies, acupuncture improves objective CRCD directly, but it may improve subjective CRCD indirectly through co-morbid symptoms. Informed by this prior work, Dr. Liou will test a novel acupuncture intervention that directly targets CRCD with the optionality to jointly address symptoms co-occurring with CRCD. RESEARCH: Dr. Liou will evaluate the association between co-morbid symptoms and CRCD in a cross-sectional study of PC survivors (Aim 1). Dr. Liou will then evaluate the feasibility and preliminary effects of acupuncture for CRCD and co-morbid symptoms in a pilot randomized controlled trial of PC survivors (Aim 2). CAREER DEVELOPMENT: Dr. Liou will acquire competence in CRCD evaluation, PC symptom science, clinical trial design, biostatistics, and grant-writing. His training will be supported by mentorship, coursework, independent study, workshops, conferences, and preparation of manuscripts and grants. MENTORS: Dr. Liou will be mentored by a team of internationally-recognized researchers with complementary expertise in CRCD, neuropsychological assessment, PC symptom science, integrative medicine, oncology acupuncture, clinical trial design, biostatistics, and PC medicine. ENVIRONMENT: Memorial Sloan Kettering Cancer Center will provide the institutional support and resources for the research. IMPACT: The proposed studies have potential to advance multi-factorial understanding of CRCD and expand non-pharmacological treatment options for prevalent symptoms affecting the aging PC population. Dr. Liou will acquire the preliminary data to support a competitive R01 grant application to test the efficacy of acupuncture for CRCD and comorbid symptoms in PC survivors. This award will establish the foundation for an independent research program with sustained impact in PC survivorship care, cognitive health, and integrative oncology.

项目摘要 该职业发展奖，针灸针对前列腺癌的老年幸存者的认知健康奖 （成就），将培训刘博士成为具有综合性专业知识的独立临床评估者 前列腺癌（PC）存活中认知健康和症状管理的疗法。背景： 到2030年，PC存活率预计将成为美国最大的癌症存活。 与癌症相关的认知功能障碍（CRCD）在这一不断增长的人群中是一个重大关注的问题，但证据 - 缺乏基于基于的治疗方法。 PC中的大多数CRCD研究都集中在雄激素的神经毒性上 剥夺疗法（ADT）。但是，关于ADT和CRCD之间关联的文献仍然混杂， 提出其他因素可能在CRCD中起作用。来自其他人群的研究表明 合并症状（焦虑，抑郁，疲劳，失眠，夜尿）可能导致认知功能障碍。 这些症状在PC存活中普遍存在，但是它们在CRCD中的作用在 PC人群。扩大CRCD的研究超出了不可修改的因素（先前的ADT暴露）和 专注于可修改因素（合并症状）有可能告知新型治疗方法 对于CRCD。根据Liou博士的初步研究，针灸可直接改善目标CRCD，但可以 通过合并症状间接改善主观CRCD。通过这项先前的工作，Liou博士将测试 一种新型的针灸干预措施，该干预直接针对CRCD，其可选性可以共同解决症状 与CRCD共发生。研究：Liou博士将评估共摩林症状之间的关联 和CRCD在PC存活的横断面研究中（AIM 1）。然后，Liou博士将评估可行性和 针灸对CRCD和合并症症状的初步作用在试验的随机对照试验中 PC冲浪者（AIM 2）。职业发展：Liou博士将获得CRCD评估的能力，PC 症状科学，临床试验设计，生物统计学和赠款写作。他的培训将得到 精通训练，课程工作，独立研究，讲习班，会议和手稿的准备 赠款。导师：刘博士将由国际认可的研究人员考虑 CRCD，神经心理学评估，PC症状科学的完全专业知识，整合 医学，肿瘤学针灸，临床试验设计，生物统计学和PC医学。环境： 纪念斯隆·凯特林（Sloan Kettering）癌症中心将为研究提供机构支持和资源。 影响：拟议的研究有可能提高对CRCD的多因素理解并扩展 普遍症状的非药物治疗选择影响PC衰老的人群。 Liou Will博士 获取初步数据，以支持有竞争力的R01赠款申请以测试针灸的效率 用于PC存活中的CRCD和合并症症状。该奖项将为独立 对PC生存护理，认知健康和综合肿瘤学的持续影响的研究计划。