MENTORED PATIENT-ORIENTED RESEARCH TOWARDS OPTIMIZING CARDIOVASCULAR OUTCOMES IN CHRONIC KIDNEY DISEASE

指导以患者为导向的研究，以优化慢性肾脏病的心血管结果

• 批准号: 10525521
• 负责人: Sankar Dass Navaneethan
• 金额: $ 11.82万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10525521
• 关键词: Adoption; Affect; Agonist; Albumins; Albuminuria; Angiotensin Receptor; Angiotensin-Converting Enzyme Inhibitors; Area; Biological Markers; Cardiac; Cardiovascular Diseases; Cardiovascular system; Chronic Kidney Failure; Clinical; Clinical Practice Guideline; Clinical Research; Clinical Trials; Creatinine; Data; Diabetes Mellitus; Diagnostic; Disease Progression; Documentation; EFRAC; Educational workshop; End stage renal failure; Enrollment; Event; Faculty; Functional disorder; Future; GLP-I receptor; Glucose; Goals; Guidelines; Health system; Heart Atrium; Heart failure; High Prevalence; Hospitalization; Hypertension; Hypoglycemic Agents; Inflammation; Institution; International; Intervention Studies; Kidney; Kidney Diseases; Kidney Failure; Leadership; Learning; Left; Lung; Medical Students; Medicine; Mentors; Metabolic Diseases; Midcareer Investigator Award in Patient-Oriented Research; Morbidity - disease rate; Nephrology; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Oxidative Stress; Patients; Pattern; Pharmaceutical Preparations; Placebos; Population; Pulmonary Hypertension; Renal dialysis; Renal function; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Risk; Risk Factors; Role; Sodium; Testing; Therapeutic; Therapeutic Agents; Time; Toxin; Tubular formation; Vascular calcification; Ventricular; Veterans Health Administration; advanced disease; aged; burden of illness; cardiovascular risk factor; clinical practice; college; diabetic; endothelial dysfunction; epidemiology study; experience; follow-up; improved; improved outcome; inhibitor; interest; lung pressure; mortality; mortality risk; non-diabetic; novel therapeutics; patient oriented research; pressure; professor; pulmonary arterial pressure; research study; skills; symporter; systematic review; uptake; urinary

PROJECT SUMMARY This application is for a K24 Midcareer Investigator Award in Patient-Oriented Research for Dr. Sankar Navaneethan. He is a Professor of Medicine and Director of Clinical Research in the Section of Nephrology, at Baylor College of Medicine. Dr. Navaneethan’s research projects have focused on improving cardiovascular and kidney outcomes for those with and at risk of chronic kidney disease (CKD). He has extensive experience in epidemiological investigations, clinical trials, and systematic reviews. Over the past decade, he has mentored trainees at different levels including medical students, residents, fellows, and junior faculty on various patient-oriented research studies. Current proposal would help him achieve following goals: a) dedicate additional time to mentor young investigators in various patient-oriented research projects related to cardiovascular disease in kidney disease, b) learn new skills in mentoring skills through both formal courses and workshops and interactions from mentors within and outside his institution, c) enhance ongoing patient- oriented research activities in obesity and impact of other metabolic diseases on cardiovascular disease in CKD population, d) to identify new scientific areas of patient-oriented research that are critical to improvement in cardiovascular outcomes of CKD population, and e) to develop leadership skills. Proposed research projects by the applicant over the 5-years would help understand the uptake of and barriers in the adoption of cardio- kidney protective medications among those with kidney disease and investigate the potential role of sodium- glucose cotransporter-2 inhibitors (SGLT2i) in improving outcomes of those with pulmonary hypertension. These projects would utilize and expand PI’s current research infrastructure and provide data for future interventional studies. Aim of the first project is to study the pattern of initiation and uptake of SGLT2i and glucagon-like peptide-1 receptor agonists (GLP-1RA) among those with kidney disease using data collected from the Veterans Affairs health system. Objectives of the second project is to conduct a pilot non-randomized study to examine the effects of SGLT2i on pulmonary artery pressure in those with CKD.

项目总结 此申请表是为Sankar博士申请以患者为中心的研究的K24职业中期研究人员奖 纳瓦尼森。他是医学教授和肾脏病学部临床研究主任。 贝勒医学院。纳瓦尼森博士的研究项目专注于改善心血管疾病 以及慢性肾脏疾病(CKD)患者和风险人群的肾脏结局。他有丰富的经验 在流行病学调查、临床试验和系统评价中。在过去的十年里，他 指导不同级别的实习生，包括医学生、住院医生、研究员和初级教师 各种以病人为中心的研究。目前的提议将帮助他实现以下目标：a)致力于 额外的时间在各种以患者为导向的研究项目中指导年轻的研究人员 肾脏疾病中的心血管疾病，b)通过两个正式课程学习指导技能的新技能 以及来自其机构内外导师的研讨会和互动，c)增强持续的患者- 年肥胖和其他代谢性疾病对心血管疾病影响的定向研究活动 CKD人群，d)确定以患者为中心的研究的新科学领域，这些领域对改进至关重要 在CKD人群的心血管结果中，以及e)发展领导技能。建议的研究项目 申请者在5年内所做的调查将有助于了解采用有氧运动的情况和障碍。 肾脏疾病患者的肾脏保护药物，并研究钠- 葡萄糖协同转运蛋白-2抑制剂(SGLT2i)改善肺动脉高压患者的预后。 这些项目将利用和扩展PI现有的研究基础设施，并为未来提供数据 介入研究。第一个项目的目的是研究SGLT2i和SGLT2i的起始和摄取模式。 利用收集的数据在肾脏疾病患者中应用胰升糖素样肽-1受体激动剂(GLP-1RA) 来自退伍军人事务部医疗系统。第二个项目的目标是进行非随机化试点 目的：观察SGLT2i对慢性肾功能不全患者肺动脉压的影响。