2022 Midwest Platelet Conference

中西部血小板会议将于 9 月 29 日至 10 月 30 日在密歇根州安娜堡举行。这是第18次会议 一系列旨在展示血小板生物学在基础、临床和转化方面最具创新性的科学 站在该领域的最前沿，并支持受训者和年轻研究人员在该领域发展科学 血小板、止血和血栓形成。中西部血小板会议 (MPC) 成立于 38 年前，旨在促进 研究血小板、血管生物学、血栓形成和血栓形成的既定研究者和受训者之间的相互作用 止血。本次会议与 NIH 和 NHLBI 的目标密切一致，即了解血小板如何 其在动脉和静脉血栓形成、止血、免疫血栓性疾病和炎症中的功能及其作用 为了开发更好的方法来治疗这些病理状况。血小板起着至关重要的作用 维持止血。正常生理条件下，血小板有循环作用，与血管无亲和力 覆盖血管表面的内皮细胞。然而，当血管内皮细胞受伤时，血小板会结合 与暴露在底层内皮基质中的胶原蛋白具有高亲和力。这种互动还导致其他 粘附相互作用导致其他血小板的激活及其相互结合形成聚集体。 除了在止血途径中的基本功能外，血小板还分泌超过 300 种生物活性分子，这些分子 具有调节关键生物过程所必需的一系列其他特性，包括纤维蛋白溶解、 伤口修复、增殖、血管生成和炎症等等。这些生物过程紧密相连 受血小板和血管壁内皮细胞之间的串扰调节。互动/沟通中的缺陷 血小板和内皮细胞之间的相互作用会损害血管的完整性，最终导致心血管疾病 疾病（CVD），包括心脏病和中风，它们是美国的主要原因。本次会议是 一个重要的基层论坛，供受训者和初级调查人员展示他们的发现，接收批评反馈 关于他们的学习以及与来自美国各地的学员和教师的网络。为此，有一个重点是 展示未发表的数据，以确保展示血液领域许多领域的前沿研究 凝血和血小板。与 NIH 和 NHLBI 的重点一致，重点关注女性的包容性， 会议中代表性不足的少数族裔和年轻研究人员，包括本科生、研究生、 博士后研究员、临床研究员、初级教师和身体残疾的个人。会议将 包括 6 场会议中学员的口头演讲时段以及专门会议中的 50 场海报讨论。 口头会议将重点讨论的主题包括：血小板研究新技术、血小板生物化学和 信号传导，临床中的血小板疾病，血小板粘附、聚集和分泌，抗血小板新进展 转化研究中的治疗，以及血小板研究的新兴趋势。中西部板块的目标 会议旨在汇集领先的专家和学员，以促进自由交流思想，从而引导 预防或治疗由血小板活性失调引起的危及生命的疾病的进展。

The Midwest Platelet Conference will be held in Ann Arbor, MI, September 29th - October 30th. This is the 18th meeting in a series established to showcase the most innovative science in platelet biology in the basic, clinical, and translational forefronts of the field and support the trainees and young investigators as they develop their science in the field of platelets, hemostasis, and thrombosis. The Midwest Platelet Conference (MPC) was established 38 years ago to promote interactions between established investigators and trainees studying platelets, vascular biology, thrombosis and hemostasis. This conference is closely aligned with the goals of the NIH and NHLBI to understand how the platelet functions and its role in arterial and venous thrombosis, hemostasis, immune-thrombotic diseases, and inflammation in order to develop better approaches to treating these pathological conditions. Platelets play an essential role in maintaining hemostasis. Under normal physiological conditions, platelets circulate and have no affinity for vascular endothelial cells that cover the surface of blood vessels. However, upon injury to blood endothelial cells, platelets bind with high affinity to the collagen exposed in the underlying sub-endothelial matrix. This interaction also leads to other adhesive interactions that result in the activation of other platelets and their binding with each other to form an aggregate. In addition to their essential function in the hemostatic pathway, platelets also secrete >300 bioactive molecules, which have a range of other properties that are essential for modulation of key biological processes including fibrinolysis, wound repair, proliferation, angiogenesis and inflammation, just to name a few. These biological processes are tightly regulated by a crosstalk between platelets and vessel wall endothelial cells. A defect in the interactions/communications between platelets and endothelial cells can compromise the integrity of blood vessels culminating in cardiovascular disease (CVD) including heart attacks and strokes, which are the leading causes of death in the US. This conference is an essential grassroots forum for trainees and junior investigators to present their findings, receive critical feedback on their studies and network with trainees and faculty from around the US. To this end, there is an emphasis on presentation of unpublished data to ensure the presentation of cutting edge research in many fields focused in blood clotting and platelets. In line with the focus of the NIH and NHLBI, there is a focus on inclusion of women, underrepresented minorities, and young investigators in the conference including undergraduates, graduate students, postdoctoral fellows, clinical fellows, junior faculty, and individuals with physical disabilities. The conference will include oral presentation slots for trainees in each of 6 session as well as 50 poster discussions in a dedicated session. The oral sessions will focus on topics including: New technologies in platelet research, Platelet biochemistry and signaling, Platelet disorders in the clinic, Platelet adhesion, aggregation, and secretion, New advances in antiplatelet therapy in translational research, and Emerging trends in platelet research. The goal of the Midwest Platelet Conference is to bring together leading experts and trainees in order to foster free exchange of ideas that will lead to advances in preventing or treating life-threatening diseases caused by dysregulation of platelet activity.