2022 Midwest Platelet Conference

中西部血小板大会将于9月29日至10月30日在密歇根州安娜堡举行。这是第18次会议 在一系列旨在展示基础、临床和翻译方面的血小板生物学最具创新性的科学中 并支持受训人员和青年研究人员在该领域发展他们的科学 血小板、止血和血栓形成。中西部血小板会议(MPC)成立于38年前，旨在促进 研究血小板、血管生物学、血栓形成和疾病的知名研究人员和受训人员之间的互动 止血。这次会议与NIH和NHLBI的目标密切一致，以了解血小板如何 动脉和静脉血栓形成、止血、免疫性血栓性疾病和炎症的功能和作用 以便开发更好的方法来治疗这些病理情况。血小板在心脏疾病中起着至关重要的作用 维持止血。在正常生理条件下，血小板循环，对血管没有亲和力。 覆盖血管表面的内皮细胞。然而，当血液内皮细胞受到损伤时，血小板就会结合 与下面的内皮下基质中暴露的胶原蛋白具有高亲和力。这种互动还会导致其他 粘附性相互作用，导致其他血小板被激活，并相互结合形成聚集体。 除了在止血途径中的基本功能外，血小板还分泌&gt；300生物活性分子，这些分子 具有调节包括纤溶在内的关键生物过程所必需的一系列其他特性， 伤口修复、增殖、血管生成和炎症，仅举几例。这些生物过程是紧密的 受血小板和血管壁内皮细胞之间的串扰调节。互动/交流中的缺陷 血小板和内皮细胞之间的相互作用会损害血管的完整性，最终导致心血管疾病 心脏病(CVD)包括心脏病发作和中风，这是美国的主要死亡原因。这次会议是 一个重要的基层论坛，供受训者和初级调查人员展示他们的发现，接收批判性反馈 关于他们的学习，并与来自美国各地的实习生和教职员工建立网络。为此，有一个重点是 展示未发表的数据，以确保展示侧重于血液的许多领域的尖端研究 凝血和血小板。与NIH和NHLBI的重点一致，重点是纳入妇女， 代表不足的少数族裔，以及参加会议的年轻研究人员，包括本科生、研究生、 博士后研究员、临床研究员、初级教员和肢体残疾人士。会议将于 包括为受训者提供的口头陈述时段，每期6次，以及在专门的一次会议中提供50张海报讨论。 口头会议将集中讨论以下主题：血小板研究中的新技术、血小板生化和 信号传导，临床中的血小板紊乱，血小板黏附、聚集和分泌，抗血小板的新进展 翻译研究中的治疗，以及血小板研究的新趋势。中西部帕特莱特的目标 会议的目的是将领先的专家和受训人员聚集在一起，以促进自由交流思想，这将导致 涉及到预防或治疗由血小板活性失调引起的危及生命的疾病的进展。

The Midwest Platelet Conference will be held in Ann Arbor, MI, September 29th - October 30th. This is the 18th meeting in a series established to showcase the most innovative science in platelet biology in the basic, clinical, and translational forefronts of the field and support the trainees and young investigators as they develop their science in the field of platelets, hemostasis, and thrombosis. The Midwest Platelet Conference (MPC) was established 38 years ago to promote interactions between established investigators and trainees studying platelets, vascular biology, thrombosis and hemostasis. This conference is closely aligned with the goals of the NIH and NHLBI to understand how the platelet functions and its role in arterial and venous thrombosis, hemostasis, immune-thrombotic diseases, and inflammation in order to develop better approaches to treating these pathological conditions. Platelets play an essential role in maintaining hemostasis. Under normal physiological conditions, platelets circulate and have no affinity for vascular endothelial cells that cover the surface of blood vessels. However, upon injury to blood endothelial cells, platelets bind with high affinity to the collagen exposed in the underlying sub-endothelial matrix. This interaction also leads to other adhesive interactions that result in the activation of other platelets and their binding with each other to form an aggregate. In addition to their essential function in the hemostatic pathway, platelets also secrete >300 bioactive molecules, which have a range of other properties that are essential for modulation of key biological processes including fibrinolysis, wound repair, proliferation, angiogenesis and inflammation, just to name a few. These biological processes are tightly regulated by a crosstalk between platelets and vessel wall endothelial cells. A defect in the interactions/communications between platelets and endothelial cells can compromise the integrity of blood vessels culminating in cardiovascular disease (CVD) including heart attacks and strokes, which are the leading causes of death in the US. This conference is an essential grassroots forum for trainees and junior investigators to present their findings, receive critical feedback on their studies and network with trainees and faculty from around the US. To this end, there is an emphasis on presentation of unpublished data to ensure the presentation of cutting edge research in many fields focused in blood clotting and platelets. In line with the focus of the NIH and NHLBI, there is a focus on inclusion of women, underrepresented minorities, and young investigators in the conference including undergraduates, graduate students, postdoctoral fellows, clinical fellows, junior faculty, and individuals with physical disabilities. The conference will include oral presentation slots for trainees in each of 6 session as well as 50 poster discussions in a dedicated session. The oral sessions will focus on topics including: New technologies in platelet research, Platelet biochemistry and signaling, Platelet disorders in the clinic, Platelet adhesion, aggregation, and secretion, New advances in antiplatelet therapy in translational research, and Emerging trends in platelet research. The goal of the Midwest Platelet Conference is to bring together leading experts and trainees in order to foster free exchange of ideas that will lead to advances in preventing or treating life-threatening diseases caused by dysregulation of platelet activity.