2022 Midwest Platelet Conference

中西部血小板会议将于9月29日至10月30日在密歇根州安阿伯举行。这是第十八次会议 在一系列建立，以展示最具创新性的科学血小板生物学的基础，临床和转化 该领域的前沿，并支持学员和年轻的研究人员，因为他们发展他们在该领域的科学 血小板、止血和血栓形成。中西部血小板会议（MPC）成立于38年前， 研究血小板、血管生物学、血栓形成和 止血。本次会议与NIH和NHLBI的目标密切相关，以了解血小板如何在体内表达。 功能及其在动脉和静脉血栓形成、止血、免疫血栓性疾病和炎症中的作用， 以开发更好的方法来治疗这些病理状况。血小板在以下方面发挥着重要作用： 维持止血。在正常的生理条件下，血小板循环并且对血管内皮细胞没有亲和力。 覆盖血管表面的内皮细胞。然而，在损伤血液内皮细胞时，血小板结合 对暴露在下面的内皮下基质中的胶原蛋白具有高亲和力。这种相互作用也导致其他 粘附相互作用，其导致其它血小板的活化以及它们彼此结合以形成聚集体。 除了在止血途径中的基本功能外，血小板还分泌>300种生物活性分子， 具有一系列对于调节包括纤维蛋白溶解在内的关键生物过程至关重要的其它性质， 伤口修复、增殖、血管生成和炎症，仅举几例。这些生物过程紧密地 由血小板和血管壁内皮细胞之间的串扰调节。互动/沟通中的缺陷 血小板和内皮细胞之间的相互作用会损害血管的完整性，最终导致心血管疾病。 心血管疾病（CVD），包括心脏病发作和中风，这是美国的主要死亡原因。本次大会是 一个重要的基层论坛，供学员和初级调查人员介绍他们的调查结果， 在他们的研究和网络与学员和教师来自美国各地。为此，强调 介绍未发表的数据，以确保介绍血液中许多领域的前沿研究 凝血和血小板根据国家卫生研究院和国家卫生法律基础研究所的重点，重点是纳入妇女， 代表性不足的少数民族，以及会议中的年轻研究人员，包括本科生，研究生， 博士后研究员、临床研究员、初级教师和身体残疾者。会议将 包括在6节课中每节课为学员安排口头介绍时间，并在一节专门课中安排50个海报讨论。 口头会议将侧重于主题，包括：血小板研究的新技术，血小板生物化学和 信号转导，临床血小板疾病，血小板粘附、聚集和分泌，抗血小板药物新进展 转化研究中的治疗，以及血小板研究中的新兴趋势。中西部血小板的目标 会议将汇集领先的专家和学员，以促进自由交流思想， 涉及在预防或治疗由血小板活性失调引起的危及生命的疾病方面的进展。

The Midwest Platelet Conference will be held in Ann Arbor, MI, September 29th - October 30th. This is the 18th meeting in a series established to showcase the most innovative science in platelet biology in the basic, clinical, and translational forefronts of the field and support the trainees and young investigators as they develop their science in the field of platelets, hemostasis, and thrombosis. The Midwest Platelet Conference (MPC) was established 38 years ago to promote interactions between established investigators and trainees studying platelets, vascular biology, thrombosis and hemostasis. This conference is closely aligned with the goals of the NIH and NHLBI to understand how the platelet functions and its role in arterial and venous thrombosis, hemostasis, immune-thrombotic diseases, and inflammation in order to develop better approaches to treating these pathological conditions. Platelets play an essential role in maintaining hemostasis. Under normal physiological conditions, platelets circulate and have no affinity for vascular endothelial cells that cover the surface of blood vessels. However, upon injury to blood endothelial cells, platelets bind with high affinity to the collagen exposed in the underlying sub-endothelial matrix. This interaction also leads to other adhesive interactions that result in the activation of other platelets and their binding with each other to form an aggregate. In addition to their essential function in the hemostatic pathway, platelets also secrete >300 bioactive molecules, which have a range of other properties that are essential for modulation of key biological processes including fibrinolysis, wound repair, proliferation, angiogenesis and inflammation, just to name a few. These biological processes are tightly regulated by a crosstalk between platelets and vessel wall endothelial cells. A defect in the interactions/communications between platelets and endothelial cells can compromise the integrity of blood vessels culminating in cardiovascular disease (CVD) including heart attacks and strokes, which are the leading causes of death in the US. This conference is an essential grassroots forum for trainees and junior investigators to present their findings, receive critical feedback on their studies and network with trainees and faculty from around the US. To this end, there is an emphasis on presentation of unpublished data to ensure the presentation of cutting edge research in many fields focused in blood clotting and platelets. In line with the focus of the NIH and NHLBI, there is a focus on inclusion of women, underrepresented minorities, and young investigators in the conference including undergraduates, graduate students, postdoctoral fellows, clinical fellows, junior faculty, and individuals with physical disabilities. The conference will include oral presentation slots for trainees in each of 6 session as well as 50 poster discussions in a dedicated session. The oral sessions will focus on topics including: New technologies in platelet research, Platelet biochemistry and signaling, Platelet disorders in the clinic, Platelet adhesion, aggregation, and secretion, New advances in antiplatelet therapy in translational research, and Emerging trends in platelet research. The goal of the Midwest Platelet Conference is to bring together leading experts and trainees in order to foster free exchange of ideas that will lead to advances in preventing or treating life-threatening diseases caused by dysregulation of platelet activity.