2022 Microbial Stress Response GRC/GRS

2022 微生物应激反应 GRC/GRS

• 批准号: 10537001
• 负责人: Jue D. Wang
• 金额: $ 0.65万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-07 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10537001
• 关键词: Academia; Agriculture; Antibiotic Resistance; Antibiotics; Archaea; Area; Atmosphere; Bacteria; Bacterial Physiology; Bacteriophages; Biochemistry; Biology; Biotechnology; Cell physiology; Characteristics; Clustered Regularly Interspaced Short Palindromic Repeats; Communities; Ecology; Environment; Equilibrium; Face; Faculty; Female; Fostering; Funding; Gender; Gene Expression; Genetic; Genetic Diseases; Genome; Geography; Goals; Health; Hour; Human; Ice; Illinois; Immune system; Industry; Institutes; Institution; Interdisciplinary Study; International; Intestines; Investigation; Leadership; Learning; Malignant Neoplasms; Mammals; Medical; Metabolism; Metagenomics; Microbe; Minority; Modernization; Molecular; Nutrient; Oral; Organism; Oxidative Stress; Pathogenesis; Phenotype; RNA Processing; Recording of previous events; Request for Proposals; Research; Research Personnel; Role; Science; Scientist; Senior Scientist; Shapes; Site; Stress; Structure; Students; Symbiosis; System; Temperature; Time; United States National Institutes of Health; Universities; Woman; Work; bacterial community; beneficial microorganism; biological adaptation to stress; career; cell community; cohort; collaborative environment; college; diversity and inclusion; geochemistry; graduate student; host-microbe interactions; imaging genetics; innovation; interest; meetings; member; microbial; multidisciplinary; novel strategies; peer; posters; prevent; professor; proteostasis; repaired; response; single cell analysis; stressor; student participation; success; symposium; undergraduate student; women faculty

Project Summary Bacteria and Archaea face a nearly constant onslaught of diverse stressors, including nutrient limitations, temperature changes, antibiotics, phage, host immune systems, and more. Whether they can properly detect and respond to such stressors largely determines their survival in a world of fierce competition. Microbes have evolved finely tuned and sophisticated regulatory mechanisms for responding to stress by controlling genome duplication and repair, gene expression, proteostasis, RNA processing, and both central and secondary metabolism - collectively, these responses enable survival in a range of harsh conditions. Thus, delineating how microbes respond to stress will elucidate the fundamental principles governing key cellular processes that are conserved from bacteria to humans where they prevent genetic disease and cancer. Understanding how microbes respond to stress impacts areas such as biotechnology, ecology, environmental biology, geochemical cycles, as well as the symbiosis and pathogenesis relationships that microbes establish with their eukaryotic hosts. The latest advances in this field will be the subject of the 2022 Gordon Research Conference (GRC) on Microbial Stress Response to be held July 17-22nd at Mount Holyoke College. This meeting will bring together a demographically diverse group of 200 international scientists seeking to understand how microbes sense and respond to challenging and ever-changing environments. Attendees are encouraged to present posters of their most exciting research. Emphasis will be placed on new approaches to understanding interactions between microbes and the environment, particularly modern imaging, genetic, metagenomic, and computational strategies for the analysis of bacterial physiology and community structures under conditions of stress and competition. A key feature of this conference is its welcoming and highly interactive environment that brings together investigators at all levels. Invited speakers include established and highly recognized scientists as well as junior investigators. Approximately 50% of invited speakers are women and 40% of oral presentations will be selected from the submitted abstracts with an emphasis on those by new investigators, postdoctoral scientists, and graduate students. Postdoctoral and graduate student participation is further encouraged by the accompanying Gordon Research Seminar (GRS), organized by students, trainees, and early stage investigators for their peers. We anticipate the 2020 Microbial Stress Response GRC will continue the success of its predecessors with cutting edge discoveries unveiled for the first time to a multidisciplinary and critical audience.

项目概要 细菌和古细菌几乎持续面临着各种压力源的攻击，包括营养限制、 温度变化、抗生素、噬菌体、宿主免疫系统等等。是否能够正确检测 对这些压力源的反应在很大程度上决定了他们在激烈竞争的世界中的生存。微生物有 进化出微调和复杂的调节机制，通过控制基因组来应对压力 复制和修复、基因表达、蛋白质稳态、RNA 加工以及中枢和次级 新陈代谢——总的来说，这些反应使人能够在一系列恶劣的条件下生存。由此，划定 微生物如何应对压力将阐明控制关键细胞过程的基本原理 从细菌到人类，它们都是保守的，可以预防遗传性疾病和癌症。了解如何 微生物对生物技术、生态学、环境生物学等领域的压力影响做出反应， 地球化学循环，以及微生物与其自身建立的共生和发病机制关系 真核宿主。 该领域的最新进展将成为 2022 年戈登研究会议 (GRC) 的主题 微生物应激反应将于 7 月 17 日至 22 日在曼荷莲学院举行。这次会议将汇集 由 200 名国际科学家组成的人口多元化群体，致力于了解微生物如何感知和 应对充满挑战和不断变化的环境。我们鼓励与会者展示他们的海报 最令人兴奋的研究。重点将放在理解之间相互作用的新方法上 微生物和环境，特别是现代成像、遗传、宏基因组和计算 在压力和压力条件下分析细菌生理学和群落结构的策略 竞赛。 本次会议的一个主要特点是其温馨且高度互动的环境， 各级调查人员。受邀演讲者包括知名且高度认可的科学家以及 初级调查员。大约 50% 的受邀演讲者是女性，40% 的口头演讲将由 从提交的摘要中选出，重点是新研究人员、博士后科学家的摘要， 和研究生。进一步鼓励博士后和研究生的参与 伴随戈登研究研讨会（GRS），由学生、实习生和早期阶段组织 调查员为他们的同行。我们预计 2020 年微生物应激反应 GRC 将继续取得成功 其前辈的尖端发现首次向多学科和批判性的研究机构揭晓 观众。