2022 Microbial Stress Response GRC/GRS

项目摘要 细菌和细菌面临着几乎持续不断的各种压力源的冲击，包括营养限制， 温度变化、抗生素、噬菌体、宿主免疫系统等等。他们是否能正确地检测到 如何应对这些压力在很大程度上决定了他们在激烈竞争的世界中的生存。微生物已经 进化出精细的和复杂的调节机制，通过控制基因组来应对压力， 复制和修复，基因表达，蛋白质稳态，RNA加工，以及中枢和次级 代谢-总的来说，这些反应使生存在一系列恶劣的条件。因此， 微生物如何应对压力将阐明控制关键细胞过程的基本原则， 从细菌到人类都是保守的，它们可以预防遗传疾病和癌症。了解如何 微生物对压力影响的反应领域，如生物技术，生态学，环境生物学， 地球化学循环，以及微生物与它们建立的共生和致病关系。 真核宿主 该领域的最新进展将成为2022年戈登研究会议（GRC）的主题， 微生物应激反应将于7月17日至22日在霍利奥克山学院举行。本次会议将汇集 一个由200名国际科学家组成的人口统计学上多样化的小组，寻求了解微生物如何感知和 应对挑战和不断变化的环境。鼓励与会者展示他们的海报 最令人兴奋的研究重点将放在新的方法来理解之间的相互作用 微生物和环境，特别是现代成像，遗传，宏基因组和计算 在压力条件下分析细菌生理学和群落结构的策略， 竞争 本次会议的一个主要特点是其欢迎和高度互动的环境，汇集了 各级调查人员。受邀演讲者包括知名且备受认可的科学家以及 初级调查员大约50%的受邀演讲者是女性，40%的口头演讲将由 从提交的摘要中选出，重点是新研究者，博士后科学家， 和研究生。博士后和研究生的参与是进一步鼓励由 伴随戈登研究研讨会（GRS），由学生，学员和早期阶段组织 调查员为他们的同行。我们预计2020年微生物应激反应GRC将继续取得成功 它的前辈与尖端的发现首次公布了一个多学科和关键的 观众

Project Summary Bacteria and Archaea face a nearly constant onslaught of diverse stressors, including nutrient limitations, temperature changes, antibiotics, phage, host immune systems, and more. Whether they can properly detect and respond to such stressors largely determines their survival in a world of fierce competition. Microbes have evolved finely tuned and sophisticated regulatory mechanisms for responding to stress by controlling genome duplication and repair, gene expression, proteostasis, RNA processing, and both central and secondary metabolism - collectively, these responses enable survival in a range of harsh conditions. Thus, delineating how microbes respond to stress will elucidate the fundamental principles governing key cellular processes that are conserved from bacteria to humans where they prevent genetic disease and cancer. Understanding how microbes respond to stress impacts areas such as biotechnology, ecology, environmental biology, geochemical cycles, as well as the symbiosis and pathogenesis relationships that microbes establish with their eukaryotic hosts. The latest advances in this field will be the subject of the 2022 Gordon Research Conference (GRC) on Microbial Stress Response to be held July 17-22nd at Mount Holyoke College. This meeting will bring together a demographically diverse group of 200 international scientists seeking to understand how microbes sense and respond to challenging and ever-changing environments. Attendees are encouraged to present posters of their most exciting research. Emphasis will be placed on new approaches to understanding interactions between microbes and the environment, particularly modern imaging, genetic, metagenomic, and computational strategies for the analysis of bacterial physiology and community structures under conditions of stress and competition. A key feature of this conference is its welcoming and highly interactive environment that brings together investigators at all levels. Invited speakers include established and highly recognized scientists as well as junior investigators. Approximately 50% of invited speakers are women and 40% of oral presentations will be selected from the submitted abstracts with an emphasis on those by new investigators, postdoctoral scientists, and graduate students. Postdoctoral and graduate student participation is further encouraged by the accompanying Gordon Research Seminar (GRS), organized by students, trainees, and early stage investigators for their peers. We anticipate the 2020 Microbial Stress Response GRC will continue the success of its predecessors with cutting edge discoveries unveiled for the first time to a multidisciplinary and critical audience.