Women's oral health in the preconception period: correlates and consequences

女性孕前期的口腔健康：相关性和后果

• 批准号: 10536354
• 负责人: Julia Craig Bond
• 金额: $ 3.69万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10536354
• 关键词: Academy; Address; Adult; Affect; Age; American; Birth; Canada; Centers for Disease Control and Prevention (U.S.); Chronic; Clinic; Clinical; Clinical Research; Clinical Trials; Cluster Analysis; Cohort Studies; Collaborations; Conceptions; Data; Dental Care; Dental Epidemiology; Diagnosis; Effectiveness; Enrollment; Epidemiologic Methods; Epidemiologist; Factor Analysis; Familiarity; Fellowship; Foundations; Goals; Health; Health Promotion; Health Services; Healthcare; Human; Inflammation; Inflammatory; Internet; Intervention; Lead; Link; Literature; Longitudinal Studies; Low Birth Weight Infant; Maternal and Child Health; Measures; Mentorship; Methods; Observation in research; Observational Study; Oral; Oral health; Outcome; Patient Self-Report; Periodontitis; Population; Population Heterogeneity; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnancy loss; Premature Birth; Prevalence; Prospective cohort study; Randomized Controlled Trials; Reporting; Reproductive Health; Research; Research Methodology; Research Personnel; Risk; Risk Factors; Sample Size; Selection Bias; Spontaneous abortion; Surveys; Techniques; Time; Tooth Loss; Training; United States; Validity of Self Report; Woman; adverse pregnancy outcome; base; behavior change; bone; cohort; design; early pregnancy; epidemiology study; evidence base; improved; insight; modifiable risk; novel; oral tissue; perinatal outcomes; pre-doctoral; pregnant; reproductive; skills; time-to-pregnancy; training opportunity

Project Abstract Periodontitis is the most common chronic health condition in humans and affects an estimated 38% of adult women in the United States. Research has demonstrated a connection between periodontitis and other adverse health outcomes, including reproductive health outcomes of preeclampsia, low birthweight, and preterm birth. However, trials evaluating periodontal treatment in pregnancy have not found a consistent benefit for perinatal outcomes, suggesting that establishment of oral health prior to pregnancy may be required to influence birth outcomes. Thus, research into oral health in the preconception period may provide important insights into potential opportunities for oral health promotion, particularly because attempting conception is often accompanied with behavior changes. Prior research by this investigator evaluating preconception oral health found an association between self-reported preconception periodontitis and a prolonged time-to- pregnancy, but the association between preconception periodontitis and other perinatal outcomes remains uncharacterized. The aim of this research is to address this gap in the literature by providing insights into the causes and consequences of oral health in the preconception period using data from a large, prospective cohort study that follows women from the time they are planning a pregnancy (e.g., preconception). Specifically, Aim 1 will assess predictors of oral health and dental service use in the preconception period. Aim 2 will leverage a Target Trial Framework to emulate a randomized controlled trial to evaluate the impact of preconception receipt of periodontitis treatment among women with periodontitis on time-to-conception. Finally, Aim 3 will examine the association between preconception periodontitis and spontaneous abortion (commonly referred to as miscarriage). Taken together, the proposed project has the potential to provide broad insights into women’s oral health in the preconception period. An accompanying training plan dovetails with the research objectives to provide robust, hands-on training opportunities for the applicant to support her transition to an independent oral health epidemiologist with expertise in observational research methods. The training plan additionally outlines tailored mentorship opportunities from the sponsor and co-sponsors, all of whom are recognized experts in their fields with a track record of successful collaboration with each other and the applicant.

项目摘要 牙周炎是人类最常见的慢性健康状况，估计影响38%的成年人 美国的女性。研究表明，牙周炎和其他疾病之间存在联系。 不良健康结局，包括先兆子痫、低出生体重的生殖健康结局， 早产。然而，评估妊娠期牙周治疗的试验并没有发现一致的 围产期结果的好处，这表明在怀孕前建立口腔健康可能是必要的 来影响生育结果。因此，对孕前时期口腔健康的研究可能会提供重要的 深入了解促进口腔健康的潜在机会，特别是因为尝试受孕是 往往伴随着行为的改变。该研究者先前的研究评价了口服避孕药的孕前情况 健康发现自我报告的孕前牙周炎和延长的时间之间的联系， 但孕前牙周炎和其他围产期结局之间的关联仍然存在 没有特征的本研究的目的是通过提供对以下方面的见解来解决文献中的这一差距： 的原因和后果的口腔健康在孕前时期使用的数据，从一个大的，前瞻性的， 从妇女计划怀孕开始跟踪她们的队列研究（例如，preconception）。 具体而言，目标1将评估孕前时期口腔健康和牙科服务使用的预测因素。目的 2将利用目标试验框架来模拟随机对照试验，以评估 牙周炎妇女受孕前接受牙周炎治疗的时间。最后， 目的3将探讨孕前牙周炎和自然流产之间的关系（通常 称为流产）。总的来说，拟议的项目有可能提供广泛的见解 女性在怀孕前的口腔健康。附带的培训计划与 研究目标是为申请人提供强大的实践培训机会，以支持她的过渡 一位独立的口腔健康流行病学家，具有观察研究方法的专业知识。培训 该计划还概述了赞助商和共同赞助商定制的指导机会，所有赞助商都是 在各自的领域中，有着成功合作的记录， 申请人。