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Naturalistic Eye Movements as Clinical Markers of Everyday Cognition in Older Adults

自然眼动作为老年人日常认知的临床标志

基本信息

批准号：
10535420
负责人：
Rachel Mis
金额：
$ 2.18万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-01 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10535420
关键词：
Active Learning Activities of Daily Living Adult Age Aging Alzheimer&apos s disease related dementia Behavioral Belief Bread Caregiver Burden Clinical Clinical Markers Clinical Psychology Coffee Cognition Cognitive Cognitive Science Computers Cream Data Dementia Development Early Diagnosis Educational workshop Elderly Environment Episodic memory Ethnic Origin Eye Eye Movements Funding Future Gestures Goals Impaired cognition Individual Intervention Knowledge Lead Manuals Measures Mentorship Methods Minor Modeling Movement Nature Older Population Participant Pattern Performance Persons Population Preparation Quality of life Questionnaires Race Reality Testing Reporting Research Training Risk Risk Marker Sampling Scientist Self-Help Devices Semantics Short-Term Memory Socioeconomic Status Source Statistical Data Interpretation Structure Testing Time Training United States National Institutes of Health Universities Update Work aging population base care costs cognitive ability cognitive control cognitive skill cognitive testing computer human interaction computerized dementia risk demographics design diagnostic criteria effective intervention executive function experience functional decline functional disability functional independence healthy aging human old age (65+)improved functioning informant instrumental activity of daily living mild cognitive impairment precision medicine premature prevent programs racial bias racial diversity recruit sample fixation theories virtual reality visual tracking young adult

项目摘要

PROJECT SUMMARY/ABSTRACT Loss of independence in the ability to successfully complete activities of daily living (ADL), such as meal preparation, is a core diagnostic criterion of Alzheimer’s disease and related dementias (ADRD) and is associated with increased costs of care and decreased quality of life in older adults, but even mild, age- associated changes in cognition negatively influence the performance of everyday tasks. Thus, there exists a need for sensitive methods of assessing everyday functioning that are scalable to clinical settings and identify mechanisms for targeted intervention. Studies of individuals with dementia posit two possible distinct cognitive mechanisms for functional difficulties: impaired cognitive control and degraded task schema knowledge. However, the primary mechanisms contributing to functional changes in older adults with milder cognitive decline remain poorly understood, in part due to a lack of sensitive methods for studying everyday functioning in individuals without dementia. Eye tracking has emerged as a potential sensitive method for studying such changes. The proposed study will recruit a racially diverse sample of older adults to examine the relation between eye fixations during completion of a computer-based task of everyday functioning and clinical measures of real-world functional difficulties (e.g., performance-based test and self/informant-report questionnaires) and cognitive abilities. 110 individuals aged 65 and older without dementia (healthy n=55, mild cognitive impairment/MCI n=55) will complete a non-immersive virtual reality (VR) test of goal-directed everyday activities (making a breakfast and lunch) while eye fixation data are collected. Participants also will complete a real-world performance-based test of everyday function and cognitive tests, and participants and a knowledgeable informant will complete clinical questionnaires of everyday functioning and demographics. We predict that (i) inefficiencies in eye fixations during completion of the VR task of everyday functioning are a sensitive and valid measure of subtle functional difficulties, and (ii) patterns of eye movements during everyday tasks reflect distinct cognitive mechanisms for functional difficulties. Results of the proposed study will 1) develop a highly sensitive and scalable assessment for cognitive skills most critical for everyday functioning in a diverse aging population and 2) identify the cognitive mechanisms underlying mild difficulties with everyday activities to inform future development of targeted interventions from a precision-medicine approach that matches the interventions with individuals’ functional/cognitive profile. A training plan has been designed that consists of formal classwork, workshops, experiential learning, and mentorship to develop the applicant’s expertise in eye tracking methods, human-computer interactions, technological advancements in cognitive assessment, and advanced statistical analysis. The proposed study will take place in Temple University’s clinical psychology program, which has a successful track record of conducting impactful NIH-funded research and training research scientists.