Use of Digital Phenotyping to Understand Digital Media Influence on Adolescent Substance Use

项目摘要 这位候选人要求支持一个为期四年的培训和研究计划， 表型分析，以获得数字媒体如何影响的新的理解，如接触毒品和酒精- 网上的相关内容可能会影响青少年购买和使用药物。解决少女 物质使用是具有挑战性的，由于各种社会和环境因素，可以影响一个青年的 决定尝试毒品或酒精。使用数字媒体，包括在线接触与物质有关的 内容是对青少年生活产生日益增长的日常影响的一个潜在因素。然而，目前 了解药物和酒精相关内容的暴露在媒体平台上的差异（例如游戏， 社交媒体），也不知道在一个媒体平台上曝光是否更有可能促进药品采购 或者促成一个吸毒的例子我们对这些关系的理解存在局限性， 其次是回忆偏差和先前研究中使用的横断面调查方法。这个项目 将利用新型数字表型分析（DP）技术收集智能手机传感器数据， 关于数字媒体曝光和物质使用的积极调查。通过这种方式，我们计划确定更多 准确地说，那些影响青少年使用毒品和酒精的数字媒体接触和经历， 并相应地改进现有的临床指南。在拟议的培训计划中，候选人将建立 根据她以前使用数字表型分析来了解高风险青少年数字媒体的经验， 使用.她的培训计划包括：1）多变量纵向分析的统计方法，2）设计 和实施数字表型分析工具，以捕获真实的高风险数字体验/暴露 时间，3）设计和试点的生态瞬时干预协议，以及4）负责任的行为， 有药物使用史的青少年的数字表型研究。 符合NIDA的使命，即确定物质使用的行为、环境和社会原因 在整个生命周期中，本研究计划将1）确定数字媒体使用的哪些亚型较多 经常与暴露于药物和酒精相关的内容和2）评估哪些暴露是 更经常地与物质采购和使用的情况有关。我们亦会探讨 精神症状和在线受害对 接触物质相关内容和物质使用。本研究将在2年内进行， 15至18岁的受试者。随后的R 01提案将概述 一个生态瞬时干预协议，其目标是在数字化的基础上进行真实的时间干预， 与青少年物质使用有关的暴露/经历。

Project Summary This candidate is requesting support for a four-year program of training and research to use digital phenotyping to gain a novel understanding of how digital media influences like exposure to drug and alcohol- related content online can impact adolescent substance procurement and use. Addressing adolescent substance use is challenging due to the diverse social and environmental factors that can impact a youth’s decision to experiment with drugs or alcohol. Digital media use, including online exposure to substance-related content, is one such potential factor of growing daily influence in adolescent lives. However, little is currently known about how exposure to drug and alcohol-related content differs across media platforms (e.g. gaming, social media), nor whether exposure on one media platform may be more likely to facilitate drug procurement or precipitate an instance of substance use. This limitation in our understanding of these relationships is secondary to both recall bias and the cross-sectional survey methodology used in prior studies. This project will leverage novel digital phenotyping (DP) technology to collect smartphone sensor data in combination with active surveys about digital media exposures and substance use. In this manner, we plan to identify more accurately those digital media exposures and experiences that impact adolescent use of drugs and alcohol, and improve upon existing clinical guidance accordingly. In the proposed training plan, the candidate will build upon her previous experience in use of digital phenotyping to understand high-risk adolescent digital media use. Her training plan includes training in: 1) statistical methods for multivariate longitudinal analysis, 2) design and implementation of digital phenotyping tools that capture high-risk digital experiences/exposures in real time, 3) design and piloting of ecological momentary intervention protocols, and 4) responsible conduct of digital phenotyping research in adolescents with a history of substance use. In line with NIDA’s mission of identifying behavioral, environmental and social causes of substance use across the lifespan, this research plan will 1) determine which subtypes of digital media use are more frequently associated with exposure to drug and alcohol-related content and 2) assess which exposures are more frequently associated with instances of substance procurement and use. We will also explore the potential moderating effects of psychiatric symptoms and online victimization on the relationship between exposure to substance-related content and substance use. This study will be performed across 2 years in subjects between 15 and 18 years of age. A subsequent R01 proposal will then outline the design and pilot of an ecological momentary intervention protocol with the goal of intervening in real time upon digital exposures/experiences associated with adolescent substance use.