WashU Somatic Mosaicism across Human Tissues (SMaHT) Program Organizational Center

华盛顿大学人体组织体细胞镶嵌 (SMaHT) 项目组织中心

• 批准号: 10661968
• 负责人: Lucinda Fulton
• 金额: $ 150万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661968
• 关键词: Adoption; Affect; Autopsy; Bioinformatics; Biological; Biological Process; Budgets; Cancer Etiology; Cataloging; Cell Nucleus; Collaborations; Communication; Communication Tools; Communications Media; Communities; Complex; Consensus; Data; Development; Disease; Documentation; Educational workshop; Elements; Environment; Funding; Genome; Genomics; Goals; Health; Human; Individual; Infrastructure; Lead; Longevity; Manuals; Mediating; Methodology; Methods; Mosaicism; National Human Genome Research Institute; Network-based; Newsletter; Outcome; Participant; Pilot Projects; Policies; Press Releases; Protocols documentation; Publications; Reporting; Research; Research Personnel; Research Support; Resources; Retrieval; Sampling; Techniques; Time; Tissues; Training; Transfer Agreement; United States National Institutes of Health; Variant; Visit; Visualization; Writing; data format; data management; data portal; data sharing; data visualization; design; empowerment; epigenome; experience; feasibility testing; genome resource; genomic variation; human pangenome; human tissue; implementation strategy; innovation; meetings; multimodality; novel; operation; outreach; programs; social media; user-friendly; web site; webinar; working group

PROJECT SUMMARY The Somatic Mosaicism across Human Tissues (SMaHT) Network aims to propel discovery of new biological processes in human health and disease that are mediated by genomic variation in somatic tissues. Efficient and effective logistical and scientific coordination is vital to maximizing value of SMaHT Network data. We propose to establish the WashU SMaHT Program Organizational Center (SMaHT-OC). Our proposal combines three key strengths: 1) broad and deep expertise in genomics, bioinformatics and genome variation; 2) strong collaborative ties among the WashU management team; and 3) longstanding experience as leaders of consortia building genomic resources, including Roadmap, ENCODE, 4DN, TaRGET, CCDG, Human Pangenome Project, and IGVF. The WashU SMaHT-OC will serve as the nucleus for facilitating all activities of the SMaHT Network. We will define rules and mechanisms of communication, and will empower researchers to engage with multimodal "big bio-data". We will develop and organize management, networking, reporting methods, and regular meetings for establishing efficient and synergistic Network operations. We will provide administrative support to ensure that SMaHT Network-related resources, data and other products are available to the community. We will coordinate all Network meetings and working groups, including the Kick-Off meeting and annual meetings. We will build and manage both internal and external SMaHT Network websites, which will be designed to evolve with community needs. We will integrate and infuse the SMaHT Network with information and data from other large-scale resources and projects by navigating data sharing requirements and coordinating collaborations with other consortia. We will extend the successful IT infrastructure of the WashU Epigenome Browser to coordinate data visualization efforts to enable the scientific research community to take full advantage of the SMaHT Network. We will provide administrative and budget support for developing and managing engagement and training, including coordinating opportunities for researchers within and outside the Network. The WashU SMaHT-OC will integrate the efforts of all the funded initiatives of the diverse SMaHT Network, and, through innovative methodology, establish a research environment that promotes collaboration, coordination, and communication among Network participants and the scientific community. .

项目摘要 人类组织（SMAHT）网络的躯体镶嵌量旨在推动新发现 人类健康和疾病的生物学过程是由体细胞组织基因组变异介导的。 高效有效的后勤和科学协调对于最大化SMAHT网络数据的价值至关重要。 我们建议建立WASHU SMAHT计划组织中心（SMAHT-OC）。我们的建议 结合了三个关键优势：1）基因组学，生物信息学和基因组变异方面的广泛而深厚的专业知识； 2）WASHU管理团队之间的紧密合作关系； 3）作为领导者的长期经验 财团建设基因组资源，包括路线图，编码，4DN，Target，CCDG，人类 Pangenome项目和IGVF。 WASHU SMAHT-OC将充当核心，以促进 SMAHT网络。我们将定义沟通的规则和机制，并将使研究人员能够 与多模式“大生物数据”互动。我们将开发和组织管理，网络，报告 方法和定期会议，以建立高效且协同的网络操作。我们将提供 管理支持，以确保可用的与SMAHT网络相关的资源，数据和其他产品可用 向社区。我们将协调所有网络会议和工作组，包括开球会议 和年度会议。我们将构建和管理内部和外部SMAHT网络网站，这将 旨在随着社区需求而发展。我们将将SMAHT网络与信息集成并注入 以及通过导航数据共享要求和协调的其他大规模资源和项目的数据 与其他财团的合作。我们将扩展WASHU表观基因组成功的IT基础设施 浏览器以协调数据可视化工作，以使科学研究社区充分利用 SMAHT网络的我们将为开发和管理提供行政和预算支持 参与和培训，包括协调网络内外研究人员的机会。 WASHU SMAHT-OC将整合不同SMAHT网络的所有资助计划的努力，并将 通过创新的方法论，建立一个研究环境，以促进协作，协调， 以及网络参与者和科学界之间的沟通。 。