WashU Somatic Mosaicism across Human Tissues (SMaHT) Program Organizational Center

华盛顿大学人体组织体细胞镶嵌 (SMaHT) 项目组织中心

• 批准号: 10661968
• 负责人: Lucinda Fulton
• 金额: $ 150万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661968
• 关键词: Adoption; Affect; Autopsy; Bioinformatics; Biological; Biological Process; Budgets; Cancer Etiology; Cataloging; Cell Nucleus; Collaborations; Communication; Communication Tools; Communications Media; Communities; Complex; Consensus; Data; Development; Disease; Documentation; Educational workshop; Elements; Environment; Funding; Genome; Genomics; Goals; Health; Human; Individual; Infrastructure; Lead; Longevity; Manuals; Mediating; Methodology; Methods; Mosaicism; National Human Genome Research Institute; Network-based; Newsletter; Outcome; Participant; Pilot Projects; Policies; Press Releases; Protocols documentation; Publications; Reporting; Research; Research Personnel; Research Support; Resources; Retrieval; Sampling; Techniques; Time; Tissues; Training; Transfer Agreement; United States National Institutes of Health; Variant; Visit; Visualization; Writing; data format; data management; data portal; data sharing; data visualization; design; empowerment; epigenome; experience; feasibility testing; genome resource; genomic variation; human pangenome; human tissue; implementation strategy; innovation; meetings; multimodality; novel; operation; outreach; programs; social media; user-friendly; web site; webinar; working group

PROJECT SUMMARY The Somatic Mosaicism across Human Tissues (SMaHT) Network aims to propel discovery of new biological processes in human health and disease that are mediated by genomic variation in somatic tissues. Efficient and effective logistical and scientific coordination is vital to maximizing value of SMaHT Network data. We propose to establish the WashU SMaHT Program Organizational Center (SMaHT-OC). Our proposal combines three key strengths: 1) broad and deep expertise in genomics, bioinformatics and genome variation; 2) strong collaborative ties among the WashU management team; and 3) longstanding experience as leaders of consortia building genomic resources, including Roadmap, ENCODE, 4DN, TaRGET, CCDG, Human Pangenome Project, and IGVF. The WashU SMaHT-OC will serve as the nucleus for facilitating all activities of the SMaHT Network. We will define rules and mechanisms of communication, and will empower researchers to engage with multimodal "big bio-data". We will develop and organize management, networking, reporting methods, and regular meetings for establishing efficient and synergistic Network operations. We will provide administrative support to ensure that SMaHT Network-related resources, data and other products are available to the community. We will coordinate all Network meetings and working groups, including the Kick-Off meeting and annual meetings. We will build and manage both internal and external SMaHT Network websites, which will be designed to evolve with community needs. We will integrate and infuse the SMaHT Network with information and data from other large-scale resources and projects by navigating data sharing requirements and coordinating collaborations with other consortia. We will extend the successful IT infrastructure of the WashU Epigenome Browser to coordinate data visualization efforts to enable the scientific research community to take full advantage of the SMaHT Network. We will provide administrative and budget support for developing and managing engagement and training, including coordinating opportunities for researchers within and outside the Network. The WashU SMaHT-OC will integrate the efforts of all the funded initiatives of the diverse SMaHT Network, and, through innovative methodology, establish a research environment that promotes collaboration, coordination, and communication among Network participants and the scientific community. .

项目摘要 跨人类组织的体细胞嵌合体（SMaHT）网络旨在推动发现新的 在人类健康和疾病的生物过程中，由体细胞组织中的基因组变异介导。 高效和有效的后勤和科学协调对于最大限度地发挥SMaHT网络数据的价值至关重要。 我们建议建立WashU SMaHT计划组织中心（SMaHT-OC）。我们的建议 结合了三个关键优势：1）在基因组学，生物信息学和基因组变异方面的广泛而深入的专业知识; 2)Washu管理团队之间强大的协作关系;以及3）作为领导者的长期经验 构建基因组资源的联盟，包括Roadmap，ENCODE，4DN，TaRGET，CCDG，Human Pangenome项目和IGVF。WashU SMaHT-OC将作为促进所有活动的核心， SmaHT网络。我们将定义交流的规则和机制，并将授权研究人员， 利用多模态“生物大数据”。我们将开发和组织管理，网络，报告 方法，并定期举行会议，以建立有效和协同的网络运作。我们将提供 行政支持，以确保SMaHT网络相关资源、数据和其他产品可用 对社区的贡献我们将协调所有网络会议和工作组，包括启动会议 和年度会议。我们将建立和管理内部和外部SMaHT网络网站， 设计成与社区需求一起发展。我们将整合和注入SMaHT网络与信息 通过导航数据共享需求和协调， 与其他财团合作。我们将扩展WashU表观基因组成功的IT基础设施 浏览器协调数据可视化工作，使科学研究界能够充分利用 关于SmaHT网络我们将提供行政和预算支持， 参与和培训，包括协调网络内外研究人员的机会。 WashU SMaHT-OC将整合多样化SMaHT网络的所有资助倡议的努力， 通过创新的方法，建立一个促进合作，协调， 以及网络参与者和科学界之间的交流。 .