Neuropathology Core

项目摘要-神经病理学核心 尸检仍然是诊断导致痴呆症的疾病的金标准。它提供了知识 对于开发生物标记物，了解导致痴呆的细胞病理学是必不可少的，以及 回顾确定最可靠的早期诊断特征。没有这些信息，理性发现 针对痴呆症的疾病修正药物的研发将是不可能的。神经病理学的核心意志 追求实现国家行动局和国家适应行动方案确定的国家优先事项的双重目标，同时促进 《老龄化与痴呆症的异质性》是西北ADRC的主题。这些目标将会实现 通过以下互动目标： 1)为临床核心参与者提供最先进的死后诊断并取得结果 可及时提供给家庭、临床医生、合格的研究人员和NACC。 2)收集、管理和分发生物标本给合格的研究项目，这两个项目都在西北大学 大学和包括NCRAD和ADGC在内的多中心合作。 3)支持西北大学内部非常成功的专业研究兴趣 认知老化(SuperAgers)，非健忘性痴呆，如原发性进行性失语症(PPA)， 额颞叶退行性变(FTLD)、神经炎症和中年发作性AD(MOAD)。 4)通过强调以下内容的银行协议支持临床病理相关性的地方研究 通过体视学和密度计量学检测半球不对称的双侧组织取样 用于将细胞病理学与体内临床和成像数据进行定量比较。 5)在包括密切互动的多学科环境中培养下一代神经病理学家 与临床医生、成像师和神经解剖学家合作，并以服务于研究目标的方式 教育部分。 将疾病的细胞学基础与其临床表现结合起来，需要 神经病理学家、神经解剖学家、成像师和临床医生将神经病理的性质和分布联系起来 临床表型及其发展轨迹。为此，方案协调会每月会议提供了一个互动环境， 在严格诊断、临床病理相关性和潜在合作方面对研究员进行了出色的培训 研究。ADRC脑库、神经病理学和成像生物标记核心实验室，以及 核心领导和主任办公室和其他资源，位于同一楼层的毗连空间。这 基础设施为神经病理核心之间的多学科互动提供动态孵化器 以及ADRC的其他组成部分。

PROJECT SUMMARY -NEUROPATHOLOGY CORE Autopsy remains the gold standard for the diagnosis of diseases that cause dementia. It provides knowledge essential for developing biomarkers, understanding cellular pathology responsible for the dementia, and retrospectively identifying features most reliable for early diagnosis. Without this information rational discovery of disease-modifying drugs for dementia syndromes would not be possible. The Neuropathology Core will pursue the dual goals of fulfilling national priorities set by NIA and NAPA while also fostering the ‘Heterogeneity in Aging and Dementia’ theme of the Northwestern ADRC. These goals will be achieved through the following interactive aims: 1) Provide state-of-the-art postmortem diagnosis on Clinical Core participants and make the results available in a timely fashion to family, clinicians, qualified researchers, and NACC. 2) Collect, curate, and distribute biospecimens to qualified research projects, both within Northwestern University and for multi-center collaborations including NCRAD and ADGC. 3) Support the specialized research interests within Northwestern University on unusually successful cognitive aging (SuperAgers), non-amnestic dementias such as primary progressive aphasia (PPA), frontotemporal lobar degenerations (FTLD), neuroinflammation, and mid-life onset AD (MOAD). 4) Support local research on clinicopathologic correlation through a banking protocol that emphasizes bilateral tissue sampling for detection of hemispheric asymmetry and through stereology and densitometry for quantitative comparisons of cellular pathology with in vivo clinical and imaging data. 5) Train the next generation of neuropathologists in a multidisciplinary setting that includes close interaction with clinicians, imagers and neuroanatomists and in a manner that serves the goals of the Research Education Component. Integrating the cellular basis of the disease with its clinical manisfestations requires close interaction among neuropathologist, neuroanatomist, imager and clinician to link the nature and distribution of the neuropathology to the clinical phenotype and its trajectory. To this end, monthly CPC meetings provide an interactive setting for superb training of fellows in rigorous diagnosis, clinicopathologic correlation and potential collaborative research. The ADRC Brain Bank and Neuropathology and Imaging Biomarker Core laboratories, as well as Core Leader and Director offices and other resources, are located in contiguous space on the same floor. This infrastructure offers a dynamic incubator for multidisciplinary interactions between the Neuropathology Core and other components of the ADRC.