Neuropathology Core

神经病理学核心

• 批准号: 10264371
• 负责人: Margaret E Flanagan
• 金额: $ 47.42万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264371
• 关键词: Aging; Alzheimer' s Disease; Autopsy; Bilateral; Biological Markers; Brain; Clinical; Cognitive aging; Collaborations; Complex; Data; Databases; Dementia; Densitometry; Detection; Diagnosis; Diagnostic; Discipline; Disease; Doctor of Philosophy; Early Diagnosis; Effectiveness; Evolution; Faculty; Family; Fertilization; Floor; Formulation; Fostering; Frontotemporal Lobar Degenerations; Goals; Gold; Heterogeneity; Image; Incubators; Individual; Infrastructure; Knowledge; Laboratories; Lead; Link; Literature; Location; Mentorship; Methods; Molecular; Movement Disorders; Nature; Neuroanatomy; Neuropsychology; Paper; Participant; Pathology; Pharmaceutical Preparations; Positioning Attribute; Postdoctoral Fellow; Primary Progressive Aphasia; Protocols documentation; Research; Research Personnel; Research Project Grants; Resources; Retirement; Syndrome; System; Time; Tissue Sample; Training; Universities; Work; behavioral variant frontotemporal dementia; cellular pathology; cholinergic; clinical phenotype; diagnosis standard; disease diagnosis; education research; experience; graduate student; imager; imaging biomarker; in vivo; interest; meetings; member; middle age; morphometry; multidisciplinary; neuroimaging; neuroinflammation; neuropathology; next generation

PROJECT SUMMARY -NEUROPATHOLOGY CORE Autopsy remains the gold standard for the diagnosis of diseases that cause dementia. It provides knowledge essential for developing biomarkers, understanding cellular pathology responsible for the dementia, and retrospectively identifying features most reliable for early diagnosis. Without this information rational discovery of disease-modifying drugs for dementia syndromes would not be possible. The Neuropathology Core will pursue the dual goals of fulfilling national priorities set by NIA and NAPA while also fostering the ‘Heterogeneity in Aging and Dementia’ theme of the Northwestern ADRC. These goals will be achieved through the following interactive aims: 1) Provide state-of-the-art postmortem diagnosis on Clinical Core participants and make the results available in a timely fashion to family, clinicians, qualified researchers, and NACC. 2) Collect, curate, and distribute biospecimens to qualified research projects, both within Northwestern University and for multi-center collaborations including NCRAD and ADGC. 3) Support the specialized research interests within Northwestern University on unusually successful cognitive aging (SuperAgers), non-amnestic dementias such as primary progressive aphasia (PPA), frontotemporal lobar degenerations (FTLD), neuroinflammation, and mid-life onset AD (MOAD). 4) Support local research on clinicopathologic correlation through a banking protocol that emphasizes bilateral tissue sampling for detection of hemispheric asymmetry and through stereology and densitometry for quantitative comparisons of cellular pathology with in vivo clinical and imaging data. 5) Train the next generation of neuropathologists in a multidisciplinary setting that includes close interaction with clinicians, imagers and neuroanatomists and in a manner that serves the goals of the Research Education Component. Integrating the cellular basis of the disease with its clinical manisfestations requires close interaction among neuropathologist, neuroanatomist, imager and clinician to link the nature and distribution of the neuropathology to the clinical phenotype and its trajectory. To this end, monthly CPC meetings provide an interactive setting for superb training of fellows in rigorous diagnosis, clinicopathologic correlation and potential collaborative research. The ADRC Brain Bank and Neuropathology and Imaging Biomarker Core laboratories, as well as Core Leader and Director offices and other resources, are located in contiguous space on the same floor. This infrastructure offers a dynamic incubator for multidisciplinary interactions between the Neuropathology Core and other components of the ADRC.

项目总结-神经病理学核心 尸检仍然是诊断痴呆症疾病的金标准。它提供知识 对于开发生物标志物，理解痴呆症的细胞病理学至关重要， 回顾性地识别对于早期诊断最可靠的特征。如果没有这些信息理性的发现 治疗痴呆综合症的疾病改善药物是不可能的。神经病理学核心将 追求双重目标，既要实现国家执行机构和国家适应行动方案确定的国家优先事项， 西北ADRC的“老龄化和痴呆症的异质性”主题。这些目标将会实现 通过以下互动目标： 1)为临床核心参与者提供最先进的尸检诊断， 及时提供给家庭、临床医生、合格的研究人员和NACC。 2)收集，策划和分发生物标本到合格的研究项目，无论是在西北 大学和多中心合作，包括NCRAD和ADGC。 3)支持西北大学内的专业研究兴趣， 认知老化（SuperAgers），非遗忘性痴呆如原发性进行性失语症（PPA）， 额颞叶变性（FTLD）、神经炎症和中年发病AD（MOAD）。 4)通过强调以下内容的银行方案，支持当地临床病理相关性研究 通过体视学和光密度测定法检测半球不对称性的双侧组织取样 用于细胞病理学与体内临床和成像数据的定量比较。 5)在包括密切互动的多学科环境中培养下一代神经病理学家 与临床医生，成像师和神经解剖学家，并以服务于研究目标的方式 教育部分。 将疾病的细胞基础与其临床表现相结合需要以下因素的密切相互作用： 神经病理学家、神经解剖学家、成像师和临床医生将神经病理学的性质和分布联系起来 临床表型和它的轨迹。为此目的，每月举行的方案协调会会议提供了一个互动的环境， 在严格的诊断、临床病理相关性和潜在的合作方面对研究员进行了极好的培训 research. ADRC脑库和神经病理学和成像生物标志物核心实验室，以及 核心领导者和董事办公室及其他资源位于同一楼层的相邻空间。这 基础设施为神经病理学核心之间的多学科互动提供了一个动态的孵化器 和ADRC的其他组件。