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Early characterization of cognitive status and AD risk in African American men

非裔美国男性认知状态和 AD 风险的早期特征

基本信息

批准号：
10663664
负责人：
Darlingtina Esiaka
金额：
$ 10.31万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10663664
关键词：
Affect African American African American population Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Behavioral Biological Markers Brain Brain imaging Brain region Chronic Disease Cognition Cognitive Communities Cross-Sectional Studies Data Dementia Development Diabetes Mellitus Diagnosis Diagnostic tests Diet Discrimination Disease Progression Early Diagnosis Elderly Enrollment Environmental Risk Factor Exposure to Family Functional Magnetic Resonance Imaging Future Genes Genetic Genetic Markers Genomics Health Hypertension Impaired cognition Individual Intervention Investigation Knowledge Life Style Low income Measures Medial Mediating Mediator Mentors Moderate Activity Neighborhoods Neural Pathways Neurologic Symptoms Neuropsychology Observational Study Pathway interactions Patient Self-Report Phase Physical activity Prefrontal Cortex Reporting Research Risk Marker Risk Reduction Smoking Stress Techniques Temporal Lobe Testing Training Trauma biomarker validation brain health brain pathway caucasian American cognitive change cognitive function cognitive neuroscience cognitive training comorbidity coping diagnostic accuracy drinking experience health determinants high risk imaging biomarker imaging study improved individual variation insight lifestyle factors men mild cognitive impairment neural neuroimaging pre-clinical prevent racism risk variant sleep quality social social factors tool urban dwelling urban setting

项目摘要

PROJECT SUMMARY/ABSTRACT Although past studies done primarily on white Americans report that men have a higher risk of mild cognitive impairment (MCI) and more rapid progression from MCI to AD, we do not know if this is also the case for African American men. Early characterization of cognitive status and Alzheimer’s disease (AD) risk in older African American men is a critical unmet challenge. There have been notably few dementia studies that included substantial numbers of older African American men. In particular, there is a paucity of neuroimaging data on older African American men in the years prior to, and during, cognitive decline to AD. We will utilize a cross- sectional study of older, urban African American men to characterize genetic, social, and environmental influences on the brain and neural markers indicative of cognitive status and AD risk. My training application will not only advance our understanding of neural changes and brain activity in older African American men, especially those exposed to conditions that put them at high risk for AD, but how their brain health relates to behavioral, genetic, neural, lifestyle, social, and environmental risk factors. Using observational study during the K99 phase, I will capture brain and neural pathways to cognitive changes/decline in African Americans, while undergoing extensive training to gain mastery of neuroimaging tools and concepts, proficiency in examining brain image biomarkers, neuropsychological assessments, and task-based fMRI testing and analyses. In the R00 phase, we will examine the neural pathways through which social and environmental factors impact cognition and identify individual variability that moderates their impact. Also, we will explore if social and environmental influences are mediated by their effect on the APOE ε4 and ABCA7-80 genes to impact cognitive status and AD risk in older African American men. Understanding the mechanisms involved in brain health and AD risk in older African American men will improve our knowledge of how AD affects men, and which tailored interventions are most effective for mitigating AD risk and improving cognitive function in African American men. The development of tailored interventions is increasingly urgent given the increase in the number of African American older adults experiencing AD and the AD-associated burdens to the individuals, families, and communities. At the end of the K99, I will have obtained intensive training experience in structural and functional neuroimaging analytic techniques and increased my knowledge of cognitive and genetic markers of AD. Further, I will have gained additional expertise in aging-related chronic illness risk reduction in pre-clinical African American men. The expertise would serve as a basis for my R00 and future independent research, where I would focus on social and environmental determinants of health to observe and document factors that impact brain health and prevent Alzheimer’s disease in urban African American men.

项目总结/摘要尽管过去主要对白色美国人进行的研究报告称，男性患轻度糖尿病的风险较高，认知障碍（MCI）和更快的进展，从MCI到AD，我们不知道这是否也是如此为非裔美国人。老年人认知状态和阿尔茨海默病（AD）风险的早期特征非洲裔美国人是一个关键的未满足的挑战。值得注意的是，很少有痴呆症研究包括大量的非裔美国人。特别是，缺乏神经成像数据，老年非裔美国男性在AD认知衰退之前和期间。我们将使用交叉- 对老年、城市非裔美国男性进行横断面研究，以描述遗传、社会和环境特征对大脑和神经标记物的影响，这些标记物指示认知状态和AD风险。我的培训申请将这不仅能增进我们对老年非裔美国人神经变化和大脑活动的理解，特别是那些暴露在AD高风险环境中的人，但他们的大脑健康与行为、遗传、神经、生活方式、社会和环境风险因素。使用观察性研究， K99阶段，我将捕捉非裔美国人认知变化/下降的大脑和神经通路，接受广泛的培训，以掌握神经成像工具和概念，熟练检查大脑成像生物标记物、神经心理学评估和基于任务的功能磁共振成像测试和分析。在R 00 阶段，我们将研究社会和环境因素影响认知的神经通路并确定个体差异，以缓和其影响。此外，我们还将探讨社会和环境影响通过其对APOE ε4和ABCA 7 -80基因的作用介导，从而影响认知状态和AD 老年非裔美国人的风险。了解老年人大脑健康和AD风险的机制非裔美国人将提高我们对AD如何影响男性的认识，以及哪些量身定制的干预措施是最有效的是减轻AD风险和改善非洲裔美国男性的认知功能。发展鉴于非洲裔美国老年人数量的增加，经历AD和AD相关的个人，家庭和社区的负担。结束时 K99，我将获得结构和功能神经影像分析方面的强化培训经验技术和增加了我的认知和遗传标记的AD的知识。更进一步，我将获得在临床前非洲裔美国人与衰老相关的慢性疾病风险降低的额外专业知识。的专业知识将作为我的R 00和未来独立研究的基础，在那里我将专注于社会和健康的环境决定因素，观察和记录影响大脑健康的因素，城市非裔美国人中的阿尔茨海默病