Developing and testing a multicomponent breathwork intervention for people with chronic pain

为慢性疼痛患者开发和测试多成分呼吸干预

• 批准号: 10663651
• 负责人: Steven D Pratscher
• 金额: $ 13.31万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663651
• 关键词: Acceleration; Address; Adherence; Affect; Affective; Anger; Anxiety; Award; Awareness; Breathing; Chronic low back pain; Clinical; Clinical Research; Competence; Conduct Clinical Trials; Conscious; Data; Development Plans; Direct Costs; Emotional; Emotions; Environment; Evaluation; Exhalation; Facilities and Administrative Costs; Feedback; Florida; Foundations; Funding; Future; Goals; Human; Individual; Inhalation; Injections; Integrative Therapy; Interoception; Intervention; Interview; K-Series Research Career Programs; Knowledge; Manuals; Mental Depression; Mentored Research Scientist Development Award; Mentors; Mentorship; Mind-Body Intervention; Modeling; Modification; Movement; National Center for Complementary and Integrative Health; Operative Surgical Procedures; Opioid; Outcome; Pain; Pain Research; Pain management; Participant; Patients; Persistent pain; Persons; Physiological; Physiological Processes; Physiology; Population; Positioning Attribute; Preparation; Principal Investigator; Process; Productivity; Protocols documentation; Psychosocial Factor; Public Health; Qualifying; Randomized, Controlled Trials; Recommendation; Reproducibility; Research; Research Personnel; Respiration; Scientist; Sensory; Source; Stress; Stressful Event; System; Techniques; Testing; Therapeutic; Touch sensation; Training; Training Activity; Trauma; Treatment Factor; United States; United States National Institutes of Health; Universities; Well in self; Work; Writing; acceptability and feasibility; arm; biological systems; biopsychosocial; biopsychosocial factor; career development; chronic pain; chronic pain management; clinical pain; comparison intervention; cost; design; effective therapy; efficacy testing; emotional distress; evidence base; experience; feasibility trial; improved; innovation; mindfulness; multi-component intervention; neural; novel; pain relief; pilot test; programs; psychologic; randomized controlled design; recruit; research and development; satisfaction; showing emotion; skills; sound; symposium; therapy development; treatment as usual; trial comparing; trial design; vagus nerve stimulation; whole health; years lived with disability

Project Summary (30 lines) Project Summary/Abstract: This K01 career development award will provide Dr. Pratscher mentored training experiences that will accelerate his transition to independence as a productive researcher investigating complementary and integrative approaches for chronic pain, whole person health, and emotional well-being. Chronic pain is a major source of human suffering, and chronic low back pain (cLBP) is one of the most common, costly, and burdensome pain conditions. Pain is a sensory and affective experience, and psychosocial factors, such as emotional distress (e.g., depression), stressful life events (e.g., trauma), and unexpressed emotions (e.g., anger), contribute substantially to the persistence of pain. There is an urgent need for integrative treatments that address this complexity of chronic pain and provide significant and lasting pain relief. Breathwork interventions (i.e., therapeutic breathing practices) are promising treatments because they incorporate one of our most integrated physiological processes, respiration, to simultaneously address both physical and emotional causes and consequences of chronic pain. Therefore, the aims of the proposed research are to 1) develop and refine a multicomponent breathwork intervention (derived from Guided Respiration Mindfulness Therapy) and to 2) iteratively evaluate its feasibility and acceptability in people with cLBP. Specifically, we will modify a treatment manual to guide intervention sessions and adapt treatment fidelity evaluations to assess therapist competence and adherence to the manual. Then, we will conduct three single-arm iterations of the 8-week, individually delivered intervention, followed by a pilot randomized controlled trial comparing the most refined version of the intervention to usual care. Upon completion of each iteration, we will gather quantitative and qualitative data and meet with a panel of experts to discuss possible modifications to the intervention or protocol before proceeding with the next iteration. This work will result in a refined and reproducible multicomponent breathwork intervention that can be tested for efficacy in future research, which the candidate plans to pursue with an R-level application written during this award period. The University of Florida has a thriving clinical pain research environment that will support the candidate in completing the proposed research and career development plan. Guidance from an excellent mentoring team in addition to several training activities (e.g., seminars, conferences, independent study) will allow Dr. Pratscher to accomplish the following objectives: (1) build a foundation of knowledge in chronic pain research with emphases on biopsychosocial treatment factors; (2) obtain expertise in the processes of intervention development, refinement, and testing; and (3) enhance proficiency in the design and conduct of clinical trials to develop into a successful independent principal investigator. By completing the proposed project and training activities, Dr. Pratscher will become an independent scientist and leader in the field of breathwork interventions for chronic pain and whole person health.

项目摘要（30行） 项目概要/摘要：这个K 01职业发展奖将提供Pratscher博士指导的培训经验，这将加速他向独立的过渡，成为一名富有成效的研究人员，研究慢性疼痛，全人健康和情绪健康的补充和综合方法。慢性疼痛是人类痛苦的主要来源，慢性腰痛（cLBP）是最常见、最昂贵和最沉重的疼痛状况之一。疼痛是一种感觉和情感体验，以及心理社会因素，如情绪困扰（例如，抑郁症），压力性生活事件（例如，创伤），和未表达的情感（例如，愤怒），实质上有助于疼痛的持续性。迫切需要综合治疗，以解决慢性疼痛的这种复杂性，并提供显着和持久的疼痛缓解。呼吸工作干预（即，治疗性呼吸实践）是有希望的治疗方法，因为它们结合了我们最完整的生理过程之一，呼吸，以同时解决慢性疼痛的身体和情感原因和后果。因此，拟议研究的目的是：1）开发和完善多组分呼吸工作干预（源自引导呼吸正念疗法），2）迭代评估其在cLBP患者中的可行性和可接受性。具体来说，我们将修改治疗手册，以指导干预会议，并调整治疗保真度评估，以评估治疗师的能力和遵守手册。然后，我们将进行三次为期8周的单组迭代，单独进行干预，然后进行一项试点随机对照试验，将最完善的干预版本与常规护理进行比较。每次迭代完成后，我们将收集定量和定性数据，并与专家小组会面，讨论在进行下一次迭代之前对干预或方案进行可能的修改。这项工作将导致一个精致的和可重复的多组分呼吸干预，可以在未来的研究，候选人计划在此奖项期间编写的R级应用程序追求的有效性进行测试。佛罗里达大学有一个蓬勃发展的临床疼痛研究环境，将支持候选人完成拟议的研究和职业发展计划。除了几项培训活动外，还有优秀辅导团队的指导（例如，研讨会，会议，独立研究）将使Pratscher博士实现以下目标：（1）建立慢性疼痛研究的知识基础，重点是生物心理社会治疗因素;（2）获得干预开发，改进和测试过程中的专业知识;及（3）提高设计及进行临床试验的熟练程度，以发展成为一名成功的独立首席研究员。通过完成拟议的项目和培训活动，Pratscher博士将成为慢性疼痛和全人健康呼吸干预领域的独立科学家和领导者。