A Pipeline for Research, Education and Mentoring in Reproductive Aging

生殖衰老研究、教育和指导渠道

• 批准号: 10663641
• 负责人: Arjumand Ghazi
• 金额: $ 12.08万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663641
• 关键词: Address; Aging; Animals; Area; Attention; Award; Bachelor' s Degree; Basic Science; Biology; Brothers; Cardiovascular Diseases; Career Choice; Career Mobility; Clinic; Clinical; Committee Members; Communities; Country; Coupled; Dedications; Delayed Childbearing; Deterioration; Development; Diverse Workforce; Economics; Education; Educational Curriculum; Educational workshop; Elderly; Enrollment; Epidemiology; Exhibits; Faculty; Fellowship; Female; Fertility; Foundations; Funding; Future; Geriatrics; Geroscience; Goals; Graduate Degree; Health; Health Sciences; Human; Impaired cognition; Impairment; Infrastructure; Institution; Intervention; Knowledge; Lead; Leadership; Life; Life Expectancy; Link; Longevity; Medical Students; Menopause; Mentors; Mentorship; Molecular; Neurologic; Newsletter; Osteoporosis; Outcome; Participant; Pathway interactions; Positioning Attribute; Postdoctoral Fellow; Predisposition; Pregnancy; Public Health; Reproduction; Reproductive Health; Reproductive system; Research; Research Institute; Research Personnel; Science; Students; System; Talents; Testosterone; Therapeutic; Tissues; Training; Travel; Universities; Woman; age related; aging population; anti aging; career; comorbidity; experience; female fertility; graduate student; healthspan; healthy aging; interest; men; mortality; preservation; programs; recruit; reproductive; reproductive fitness; reproductive senescence; sabbatical; sex; summer research; trend; undergraduate student; web site

A Pipeline for Research, Education and Mentoring in Reproductive Aging Decline in female fertility is one of the earliest age-related deteriorations seen in humans, often decades before signs of somatic aging appear. From a fertility perspective, women are considered geriatric by late 30s and only ~5% experience successful natural pregnancies in their 40s. Besides fertility, menopause triggers a spectrum of negative health outcomes including increased susceptibility to cognitive decline and cardiovascular disease. Increased human life expectancy coupled to global trends of delayed child-bearing means that reproductive fitness is not only important for womens’ health, life- and career- choices, but has inescapable societal, economic and public-health implications. An expanding body of evidence reveals that reproductive senescence and somatic aging are mechanistically intimately linked. In the last two decades, support from the NIA, and others, has led to innumerable discoveries in organismal aging from basic mechanisms to potential anti-aging therapeutics. However, reproductive aging remains under-studied and its public-health significance poorly acknowledged. To develop an intellectual workforce well equipped to meet the current and future challenges of an aging population, it is critical to urgently prioritize the intersection of aging and reproduction as a focus of research, education and biomedical programs. Dr. Ghazi proposes to address this need through this K07 Academic Leadership Career award, by establishing a Pipeline for Reproductive-Aging Research, Education & Mentorship (PRAM) that spans the undergraduate-to-faculty spectrum at the University of Pittsburgh (Pitt). The central goal of this application is to create a program that will help establish Pitt as a world leader in reproductive aging. The K07 leadership award will help attain this goal by facilitating the development of a ‘pipeline’ at the university for (a) Early Recruitment (Aim 1): attract students from early academic stages towards reproductive-aging research, (b) Exceptional Education (Aim 2): organize a strong educational curriculum focused on reproductive health and aging, and (c) Sustained Mentorship (Aim 3): provide personalized, long-term mentorship and community support for researchers in this area at every career stage. Dr. Ghazi is uniquely positioned to lead this initiative because of her long-standing research expertise in aging, reproduction and their intersection, her academic leadership experience and commitment to education and mentoring. Pitt is an ideal institution for this initiative because of the presence of highly-regarded centers specifically dedicated to research on aging and reproductive health, an exemplary research and funding record, and a large, diverse pool of undergraduate, graduate and medical students. Pitt-PRAM will help establish reproductive aging as a core institutional objective at Pitt and serve as a roadmap to build an exceptionally trained Reproductive Geroscience workforce of the future.

生殖衰老研究、教育和指导渠道 女性生育能力下降是人类最早出现的与年龄相关的恶化之一，通常是几十年前 出现躯体衰老的迹象。从生育角度来看，女性到了 30 多岁就被视为老年， 只有大约 5% 的人在 40 多岁的时候经历过成功的自然怀孕。除了生育能力之外，更年期还会引发 一系列负面健康结果，包括认知能力下降的易感性增加和 心血管疾病。人类预期寿命的延长与全球推迟生育的趋势相结合 意味着生殖健康不仅对女性的健康、生活和职业选择很重要，而且 不可避免的社会、经济和公共卫生影响。越来越多的证据表明 生殖衰老和躯体衰老在机制上密切相关。在过去的二十年里， NIA 和其他机构的支持导致了从基础到有机衰老的无数发现 潜在抗衰老疗法的机制。然而，生殖衰老的研究仍未充分，其影响 公共卫生的重要性尚未得到充分认识。培养一支装备精良的知识型劳动力队伍，以满足 面对人口老龄化当前和未来的挑战，迫切需要优先考虑老龄化问题的交叉点 和生殖作为研究、教育和生物医学项目的重点。 加齐博士建议通过设立 K07 学术领导职业奖来满足这一需求 生殖衰老研究、教育和指导 (PRAM) 管道，涵盖 匹兹堡大学（Pitt）的本科生到教师范围。该应用程序的中心目标是 制定一项计划，帮助皮特成为生殖衰老领域的世界领导者。 K07领导奖 将通过促进大学内“管道”的开发来帮助实现这一目标：(a) 早期招聘 （目标 1）：吸引处于早期学术阶段的学生进行生殖衰老研究，(b) 卓越 教育（目标 2）：组织以生殖健康和老龄化为重点的强有力的教育课程，以及 (c) 持续指导（目标 3）：为以下人员提供个性化的长期指导和社区支持 该领域各个职业阶段的研究人员。加齐博士在领导这一举措方面处于独特的地位，因为 她在衰老、生殖及其交叉领域的长期研究专业知识，她的学术领导力 经验以及对教育和指导的承诺。皮特大学是这项计划的理想机构，因为 专门致力于老龄化和生殖健康研究的备受推崇的中心的存在， 堪称典范的研究和资助记录，以及大量多样化的本科生、研究生和医学生 学生。皮特-PRAM 将帮助将生殖老龄化作为皮特的核心机构目标，并作为 建立一支训练有素的未来生殖老年科学劳动力队伍的路线图。