Nonlinear analysis of the hemodynamics in the artificial heart animals as the aging acceleration model

这个国家的人口构成正在向老年化转变。因此，探究“老龄化”现象的本质是当务之急。衰老是整个生物系统的过程。因此，在过去的科学研究中，被认为是主流的还原理论无法解释的。人们认为，有必要应用一种建立了整个系统观点的分析方法。在全人工心脏动物中，一些机构报道了许多病理生理变化，如高血压、中心静脉压升高、体液因子改变等。因此，人造心脏动物被定位为“衰老加速模型”。以健康成年山羊为实验对象，观察了人工心脏动物血流动力学的时间序列变化。本研究采用非线性动力学方法进行分析，关注整个系统的动态特性。主要研究成果如下：1。尝试建立了应用非线性力学的生物特征识别程序。慢性实验性人工心脏动物血流动力学的非线性分析。与正常心脏血流动力学比较。对人工心脏动物进行自主神经活动记录。对人工心脏慢性实验动物进行了长期生存实验。观察人工心脏控制算法对这一生理机能的改变。同时考虑了控制衰老的最佳血流动力学参数。

The population composition of this country shifts to old age. Accordingly investigation of essence of "Aging" phenomenon is urgent business. Aging progresses in the whole of biological system. Thus, it is thought that it can't be elucidated by the reduction theory which was the mainstream in the past scientifis research. It is thought that application of the methodology of an analysis that established point of view with the whole system becomes necessary. In the animals with total artificial hearts, many pathophysiological changes such as Hypertension, elevation of central venous pressure, alteration of humoral factor, had been reported in some institutions.So, an artificial heart animal was positioned as "Aging acceleration model". A change in the time series courve of hemodynamics of an artificial heart animal was observed with the chronic experiment using healthy adult goats. In this research, analysis by the nonlinear dynamics which paid attention to dynamic characteristic of the whole system was used.Major research result was mentioned in the following.1. Establishment of procedure of the biometrics that nonlinear mechanics was applied was tried.2. Non-linear analysis of the hemodynamics with chronic experimental artificial heart animals. Comparison examination with hemodynamics by a natural heart was done.3. Autonomic nerve activity recording was carried out in the artificial heart animals.4.Long term survival experiment of artificial heart chronic experimental animals were carried out. The change that artificial heart control algorithrm gave to this physiology was observed. Consideration was added about the hemodynamics which was the optimum which controlled aging.