Nonlinear analysis of the hemodynamics in the artificial heart animals as the aging acceleration model

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The population composition of this country shifts to old age. Accordingly investigation of essence of "Aging" phenomenon is urgent business. Aging progresses in the whole of biological system. Thus, it is thought that it can't be elucidated by the reduction theory which was the mainstream in the past scientifis research. It is thought that application of the methodology of an analysis that established point of view with the whole system becomes necessary. In the animals with total artificial hearts, many pathophysiological changes such as Hypertension, elevation of central venous pressure, alteration of humoral factor, had been reported in some institutions.So, an artificial heart animal was positioned as "Aging acceleration model". A change in the time series courve of hemodynamics of an artificial heart animal was observed with the chronic experiment using healthy adult goats. In this research, analysis by the nonlinear dynamics which paid attention to dynamic characteristic of the whole system was used.Major research result was mentioned in the following.1. Establishment of procedure of the biometrics that nonlinear mechanics was applied was tried.2. Non-linear analysis of the hemodynamics with chronic experimental artificial heart animals. Comparison examination with hemodynamics by a natural heart was done.3. Autonomic nerve activity recording was carried out in the artificial heart animals.4.Long term survival experiment of artificial heart chronic experimental animals were carried out. The change that artificial heart control algorithrm gave to this physiology was observed. Consideration was added about the hemodynamics which was the optimum which controlled aging.