Nonlinear analysis of the hemodynamics in the artificial heart animals as the aging acceleration model

作为老化加速模型的人工心脏动物血流动力学的非线性分析

• 批准号: 06558118
• 负责人: YAMBE Tomoyuki
• 金额: $ 3.84万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06558118/
• 关键词: total artificial heart; chaos; fractal; nonlinear dynamics; aging; ventricular assist system; sympathetic nerve activity; automatic control; total artificial heart,; chaos,; fractal,; nonliner dynamics,; aging,; ventricular assist system,; s

The population composition of this country shifts to old age. Accordingly investigation of essence of "Aging" phenomenon is urgent business. Aging progresses in the whole of biological system. Thus, it is thought that it can't be elucidated by the reduction theory which was the mainstream in the past scientifis research. It is thought that application of the methodology of an analysis that established point of view with the whole system becomes necessary. In the animals with total artificial hearts, many pathophysiological changes such as Hypertension, elevation of central venous pressure, alteration of humoral factor, had been reported in some institutions.So, an artificial heart animal was positioned as "Aging acceleration model". A change in the time series courve of hemodynamics of an artificial heart animal was observed with the chronic experiment using healthy adult goats. In this research, analysis by the nonlinear dynamics which paid attention to dynamic characteristic of the whole system was used.Major research result was mentioned in the following.1. Establishment of procedure of the biometrics that nonlinear mechanics was applied was tried.2. Non-linear analysis of the hemodynamics with chronic experimental artificial heart animals. Comparison examination with hemodynamics by a natural heart was done.3. Autonomic nerve activity recording was carried out in the artificial heart animals.4.Long term survival experiment of artificial heart chronic experimental animals were carried out. The change that artificial heart control algorithrm gave to this physiology was observed. Consideration was added about the hemodynamics which was the optimum which controlled aging.

这个国家的人口组成向老年人转移。因此，对“老龄化”现象本质的研究是当务之急。衰老在整个生物系统中进行。因此，以往科学研究中的主流还原论是无法解释的。人们认为，有必要应用一种分析方法，即建立一个与整个系统的观点。在全人工心脏动物中，有研究机构报道了高血压、中心静脉压升高、体液因子改变等多种病理生理变化，因此将人工心脏动物定位为“加速老化模型”。用健康成年山羊进行慢性实验，观察了人工心脏血流动力学时间序列曲线的变化。本研究采用非线性动力学分析方法，关注整个系统的动态特性，主要研究成果如下：1.尝试建立了应用非线性力学的生物特征识别方法.慢性实验性人工心脏动物血流动力学的非线性分析。与正常心脏的血流动力学进行对比检查.对人工心脏动物进行自主神经活动记录。4.人工心脏慢性实验动物长期存活实验。观察了人工心脏控制算法对这一生理过程的影响。增加了对血液动力学的考虑，这是控制老化的最佳方法。

项目成果

T.Yambe, et al.: "Chaotic behavior of the hemodynamics with ventricular assist device." Int J Artif Organs. 18. 17-21 (1995)

T.Yambe 等人：“心室辅助装置的血流动力学混沌行为。”

T Yambe, et al.: "Spectral analysis of the hemodynamics during left ventricular assistance" Int J Artif Organs. 19. 367-371 (1996)

T Yambe 等人：“左心室辅助期间血流动力学的频谱分析”​​Int J Artif Organs。

T. Yambe, et al.: "Strange hemodynamic attractor parameter with I/R total srtificial heart sutomatic control algorithm" Int J Artif Organs. 19. 302-306 (1996)

T. Yambe 等人：“具有 I/R 总人工心脏自动控制算法的奇怪血流动力学吸引子参数”Int J Artif Organs。

T.Yambc,et al.: "Fluctuations in sympathetic nerve activity in animal without natural heartbeat." Artificial Organs. 18. 775-780 (1994)

T.Yambc 等人：“没有自然心跳的动物交感神经活动的波动。”

T Yambe, et al.: "Fractal circulation of the total artificial heart" IIAS Reports. 1996-01. 87-106 (1996)

T Yambe 等人：“全人造心脏的分形循环”IIAS 报告。