Mentoring the next generation of researchers at the intersection of opioid use disorder and chronic pain

指导下一代研究人员研究阿片类药物使用障碍和慢性疼痛的交叉点

• 批准号: 10663642
• 负责人: Jessica S Merlin
• 金额: $ 19.26万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663642
• 关键词: Active Learning; Address; Adopted; Adoption; Advanced Malignant Neoplasm; Alcohols; Area; Award; Behavior; Behavioral; Buprenorphine; Cancer Pain Management; Clinic; Clinical; Cocaine; Complication; Data; Development Plans; Diagnosis; Discipline; Disease Management; Disseminated Malignant Neoplasm; Doctor of Philosophy; Education; Equity; Evaluation; Faculty; Funding; Goals; HIV; Health; Helping to End Addiction Long-term; High Prevalence; Hybrids; Individual; Institution; Interview; Language; Leadership; Learning; Life; Life Experience; Maintenance; Malignant Neoplasms; Maps; Mentors; Methadone; Needs Assessment; Oncology; Opioid; Opioid agonist; Outcome; Pain; Pain management; Palliative Care; Participant; Pathway interactions; Patient Care; Patients; Perception; Performance; Personal Satisfaction; Persons; Physicians; Population; Postdoctoral Fellow; Primary Care; Productivity; Prognosis; Racial Equity; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Research; Research Methodology; Research Personnel; Research Project Grants; Research Proposals; Resources; Risk; Risk Factors; Science; Scientist; Sickle Cell; Specific qualifier value; Standardization; Testing; Tobacco use; Training; Translations; United States National Institutes of Health; Woman; Work; acceptability and feasibility; addiction; cancer care; career; career development; case-based; chronic abdominal pain; chronic pain; chronic pain patient; clinical practice; comorbidity; data submission; design; doctoral student; effectiveness outcome; effectiveness/implementation hybrid; evidence base; evidence based guidelines; experience; health equity; hybrid type 2 trial; implementation barriers; implementation evaluation; implementation facilitators; implementation framework; implementation protocol; implementation science; implementation strategy; improved; medication for opioid use disorder; next generation; novel; opioid misuse; opioid overdose; opioid use disorder; pilot trial; prescription opioid; programs; racial disparity; racial health disparity; randomized trial; recruit; research to practice; skills; social stigma; substance use; symposium; systematic review; treatment optimization; treatment research

Project Summary/Abstract: My overall goal is to improve the health and well-being of individuals with comorbid opioid misuse/opioid use disorder (OUD) and chronic pain across varied settings and populations. Research on the management of comorbid opioid misuse/OUD and chronic pain is being outpaced by the clinical need across populations and settings. Additionally, there is no well-worn training pathway to conduct research in this area, few mid-career and senior investigators have the expertise to mentor early-career investigators in this space, and the need for mentoring to grow the workforce is enormous. Finally, given the known racial health disparities in our field, it is especially important that researchers are representative of the populations they serve, which is currently not the case. I am a physician and PhD-trained behavioral scientist who treats individuals with opioid misuse/OUD and chronic pain. I have a consistent track record of NIH-funded research and productive mentoring at the intersection of these conditions across populations and settings including HIV, cancer, and primary care, and am at an institution with exceptional resources to support trainees. This K24 mid-career investigator award will allow me to grow the workforce at the intersection of opioid misuse/OUD and chronic pain by 1) expanding my capacity to mentor PhD students, postdoctoral scholars, and faculty from diverse disciplines—and allow me to continue to focus on women and individuals from backgrounds that are underrepresented in science—in research on comorbid opioid misuse/OUD and chronic pain; 2) Become a leader in implementation science approaches to studying treatment of comorbid opioid misuse/OUD and chronic pain, including hybrid trials; and 3) Develop the skills needed to systematically incorporate health equity considerations and research methods throughout my work. I have assembled a team of advisors with whom I have created a comprehensive career development plan including didactic coursework, experiential learning, and conference attendance that will allow me to excel at achieving these goals. Additionally, this K24 proposes a new research project that leverages existing Delphi-based preliminary data to 1) Develop an implementation strategy bundle to promote the adoption and equitable application of evidence-based approaches for managing opioid misuse/OUD and metastatic cancer-related pain, and 2) Conduct a hybrid type 2 pilot trial of the evidence-based approaches and implementation strategy bundle. Findings from this study will lead to a hybrid type 2 randomized trial of the implementation strategy bundle and ultimately improved care for patients with opioid misuse/OUD and metastatic cancer. This and other NIH- funded studies in my portfolio will provide mentees ample opportunity to propose mentored research projects. This mentored research experience, combined with a program of tailored career development opportunities, will develop a new cadre of independent investigators at the intersection of opioid misuse/OUD and chronic pain.

项目摘要/摘要：我的总体目标是改善患有以下疾病的个人的健康和福祉 不同环境和人群中的共病阿片类药物滥用/阿片类药物使用障碍 (OUD) 和慢性疼痛。 对共病阿片类药物滥用/OUD 和慢性疼痛的管理研究正在被超越 跨人群和环境的临床需求。此外，没有陈旧的培训途径来进行 在这一领域的研究中，很少有职业中期和高级研究人员拥有指导职业早期的专业知识 这个领域的研究人员，并且对指导以扩大劳动力的需求是巨大的。最后，鉴于 由于我们领域已知的种族健康差异，研究人员代表该领域尤为重要 他们所服务的人群，但目前情况并非如此。我是一名医生和受过博士学位训练的行为科学家 他治疗阿片类药物滥用/OUD 和慢性疼痛的患者。我有 NIH 资助的一贯记录 针对跨人群和环境的这些条件的交叉点进行研究和富有成效的指导 包括艾滋病毒、癌症和初级保健，并且我所在的机构拥有特殊的资源来支持 实习生。这个 K24 职业生涯中期调查员奖将使我能够在以下领域扩大员工队伍： 阿片类药物滥用/OUD 和慢性疼痛，方法是 1) 扩大我指导博士生、博士后的能力 来自不同学科的学者和教师，让我能够继续关注女性和个人 来自科学界代表性不足的背景——在共病阿片类药物滥用/OUD 的研究中， 慢性疼痛； 2) 成为研究共病治疗的实施科学方法的领导者 阿片类药物滥用/OUD 和慢性疼痛，包括混合试验； 3) 培养系统地开展工作所需的技能 在我的工作中融入健康公平的考虑和研究方法。我已经组建了一个团队 我与顾问一起制定了全面的职业发展计划，包括教学 课程作业、体验式学习和参加会议将使我能够出色地实现这些目标 目标。此外，本 K24 提出了一个新的研究项目，该项目利用现有的基于 Delphi 的初步研究 数据以 1) 制定实施策略包，以促进采用和公平应用 用于管理阿片类药物滥用/OUD 和转移性癌症相关疼痛的循证方法，以及 2) 对循证方法和实施策略包进行混合 2 类试点试验。 这项研究的结果将导致实施策略包的混合 2 型随机试验和 最终改善了对阿片类药物滥用/OUD 和转移性癌症患者的护理。这个和其他 NIH- 我的投资组合中受资助的研究将为受指导者提供充足的机会来提出受指导的研究项目。 这种指导性的研究经验与量身定制的职业发展机会计划相结合， 将在阿片类药物滥用/OUD 和慢性病交叉领域培养一支新的独立调查员队伍 疼痛。