Mentoring the next generation of researchers at the intersection of opioid use disorder and chronic pain

项目摘要/摘要：我的总体目标是通过以下方式改善个人的健康和福祉 在不同的环境和人群中，阿片类药物滥用/阿片使用障碍(OUD)和慢性疼痛并存。 阿片类药物滥用和慢性疼痛并存的管理研究正在被 跨人群和不同环境的临床需求。此外，没有一条陈旧的培训途径可以进行 在这一领域的研究中，很少有中期和高级调查人员具有指导早期职业生涯的专业知识 这一领域的研究人员，以及对指导的需求是巨大的，以扩大劳动力。最后，考虑到 在我们的领域中，众所周知的种族健康差异，尤其重要的是，研究人员代表 他们所服务的人群，但目前情况并非如此。我是一名内科医生和受过博士训练的行为科学家 世卫组织治疗有阿片类药物滥用/OUD和慢性疼痛的个人。我在美国国立卫生研究院资助的 在人口和环境中这些条件的交叉点进行研究和富有成效的指导 包括艾滋病毒、癌症和初级保健，我在一家拥有特殊资源的机构支持 实习生。这项K24职业生涯中期调查员奖将使我能够在 阿片类药物滥用/OUD和慢性疼痛，1)扩大我指导博士后、博士后的能力 来自不同学科的学者和教职员工-允许我继续关注女性和个人 来自科学界代表性不足的背景--关于阿片类药物滥用的研究/OUD 慢性疼痛；2)成为研究并存疾病治疗的实施科学方法的领导者 阿片类药物滥用/OUD和慢性疼痛，包括混合试验；以及3)发展系统地 在我的工作中融入健康公平的考虑和研究方法。我已经组建了一支队伍 与我一起创建了包括说教在内的全面职业发展计划的顾问 课程学习、体验式学习和出席会议将使我在实现这些方面出类拔萃 目标。此外，该K24提出了一个新的研究项目，该项目利用现有的基于Delphi的初步 数据用于1)制定实施战略捆绑包，以促进采用和公平应用 管理阿片类药物滥用和转移性癌症相关疼痛的循证方法，以及2) 进行基于证据的方法和实施战略捆绑的混合类型2试点试验。 这项研究的结果将导致实施战略捆绑和 最终改善了对阿片类药物滥用和转移性癌症患者的护理。这个和其他美国国立卫生研究院- 我的投资组合中资助的研究将为被辅导者提供充足的机会来提出有指导的研究项目。 这种有指导的研究经验，结合一个量身定做的职业发展机会计划， 将在阿片类药物滥用/OUD和慢性病的交叉点培养一支新的独立调查队伍 疼痛。

Project Summary/Abstract: My overall goal is to improve the health and well-being of individuals with comorbid opioid misuse/opioid use disorder (OUD) and chronic pain across varied settings and populations. Research on the management of comorbid opioid misuse/OUD and chronic pain is being outpaced by the clinical need across populations and settings. Additionally, there is no well-worn training pathway to conduct research in this area, few mid-career and senior investigators have the expertise to mentor early-career investigators in this space, and the need for mentoring to grow the workforce is enormous. Finally, given the known racial health disparities in our field, it is especially important that researchers are representative of the populations they serve, which is currently not the case. I am a physician and PhD-trained behavioral scientist who treats individuals with opioid misuse/OUD and chronic pain. I have a consistent track record of NIH-funded research and productive mentoring at the intersection of these conditions across populations and settings including HIV, cancer, and primary care, and am at an institution with exceptional resources to support trainees. This K24 mid-career investigator award will allow me to grow the workforce at the intersection of opioid misuse/OUD and chronic pain by 1) expanding my capacity to mentor PhD students, postdoctoral scholars, and faculty from diverse disciplines—and allow me to continue to focus on women and individuals from backgrounds that are underrepresented in science—in research on comorbid opioid misuse/OUD and chronic pain; 2) Become a leader in implementation science approaches to studying treatment of comorbid opioid misuse/OUD and chronic pain, including hybrid trials; and 3) Develop the skills needed to systematically incorporate health equity considerations and research methods throughout my work. I have assembled a team of advisors with whom I have created a comprehensive career development plan including didactic coursework, experiential learning, and conference attendance that will allow me to excel at achieving these goals. Additionally, this K24 proposes a new research project that leverages existing Delphi-based preliminary data to 1) Develop an implementation strategy bundle to promote the adoption and equitable application of evidence-based approaches for managing opioid misuse/OUD and metastatic cancer-related pain, and 2) Conduct a hybrid type 2 pilot trial of the evidence-based approaches and implementation strategy bundle. Findings from this study will lead to a hybrid type 2 randomized trial of the implementation strategy bundle and ultimately improved care for patients with opioid misuse/OUD and metastatic cancer. This and other NIH- funded studies in my portfolio will provide mentees ample opportunity to propose mentored research projects. This mentored research experience, combined with a program of tailored career development opportunities, will develop a new cadre of independent investigators at the intersection of opioid misuse/OUD and chronic pain.