Mentoring the next generation of researchers at the intersection of opioid use disorder and chronic pain

指导下一代研究人员研究阿片类药物使用障碍和慢性疼痛的交叉点

• 批准号: 10663642
• 负责人: Jessica S Merlin
• 金额: $ 19.26万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663642
• 关键词: Active Learning; Address; Adopted; Adoption; Advanced Malignant Neoplasm; Alcohols; Area; Award; Behavior; Behavioral; Buprenorphine; Cancer Pain Management; Clinic; Clinical; Cocaine; Complication; Data; Development Plans; Diagnosis; Discipline; Disease Management; Disseminated Malignant Neoplasm; Doctor of Philosophy; Education; Equity; Evaluation; Faculty; Funding; Goals; HIV; Health; Helping to End Addiction Long-term; High Prevalence; Hybrids; Individual; Institution; Interview; Language; Leadership; Learning; Life; Life Experience; Maintenance; Malignant Neoplasms; Maps; Mentors; Methadone; Needs Assessment; Oncology; Opioid; Opioid agonist; Outcome; Pain; Pain management; Palliative Care; Participant; Pathway interactions; Patient Care; Patients; Perception; Performance; Personal Satisfaction; Persons; Physicians; Population; Postdoctoral Fellow; Primary Care; Productivity; Prognosis; Racial Equity; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Research; Research Methodology; Research Personnel; Research Project Grants; Research Proposals; Resources; Risk; Risk Factors; Science; Scientist; Sickle Cell; Specific qualifier value; Standardization; Testing; Tobacco use; Training; Translations; United States National Institutes of Health; Woman; Work; acceptability and feasibility; addiction; cancer care; career; career development; case-based; chronic abdominal pain; chronic pain; chronic pain patient; clinical practice; comorbidity; data submission; design; doctoral student; effectiveness outcome; effectiveness/implementation hybrid; evidence base; evidence based guidelines; experience; health equity; hybrid type 2 trial; implementation barriers; implementation evaluation; implementation facilitators; implementation framework; implementation protocol; implementation science; implementation strategy; improved; medication for opioid use disorder; next generation; novel; opioid misuse; opioid overdose; opioid use disorder; pilot trial; prescription opioid; programs; racial disparity; racial health disparity; randomized trial; recruit; research to practice; skills; social stigma; substance use; symposium; systematic review; treatment optimization; treatment research

Project Summary/Abstract: My overall goal is to improve the health and well-being of individuals with comorbid opioid misuse/opioid use disorder (OUD) and chronic pain across varied settings and populations. Research on the management of comorbid opioid misuse/OUD and chronic pain is being outpaced by the clinical need across populations and settings. Additionally, there is no well-worn training pathway to conduct research in this area, few mid-career and senior investigators have the expertise to mentor early-career investigators in this space, and the need for mentoring to grow the workforce is enormous. Finally, given the known racial health disparities in our field, it is especially important that researchers are representative of the populations they serve, which is currently not the case. I am a physician and PhD-trained behavioral scientist who treats individuals with opioid misuse/OUD and chronic pain. I have a consistent track record of NIH-funded research and productive mentoring at the intersection of these conditions across populations and settings including HIV, cancer, and primary care, and am at an institution with exceptional resources to support trainees. This K24 mid-career investigator award will allow me to grow the workforce at the intersection of opioid misuse/OUD and chronic pain by 1) expanding my capacity to mentor PhD students, postdoctoral scholars, and faculty from diverse disciplines—and allow me to continue to focus on women and individuals from backgrounds that are underrepresented in science—in research on comorbid opioid misuse/OUD and chronic pain; 2) Become a leader in implementation science approaches to studying treatment of comorbid opioid misuse/OUD and chronic pain, including hybrid trials; and 3) Develop the skills needed to systematically incorporate health equity considerations and research methods throughout my work. I have assembled a team of advisors with whom I have created a comprehensive career development plan including didactic coursework, experiential learning, and conference attendance that will allow me to excel at achieving these goals. Additionally, this K24 proposes a new research project that leverages existing Delphi-based preliminary data to 1) Develop an implementation strategy bundle to promote the adoption and equitable application of evidence-based approaches for managing opioid misuse/OUD and metastatic cancer-related pain, and 2) Conduct a hybrid type 2 pilot trial of the evidence-based approaches and implementation strategy bundle. Findings from this study will lead to a hybrid type 2 randomized trial of the implementation strategy bundle and ultimately improved care for patients with opioid misuse/OUD and metastatic cancer. This and other NIH- funded studies in my portfolio will provide mentees ample opportunity to propose mentored research projects. This mentored research experience, combined with a program of tailored career development opportunities, will develop a new cadre of independent investigators at the intersection of opioid misuse/OUD and chronic pain.

项目摘要/摘要：我的总体目标是改善个人的健康和福祉， 阿片类药物滥用/阿片类药物使用障碍（OUD）共病和慢性疼痛在不同的环境和人群。 阿片类药物滥用/OUD和慢性疼痛共病管理的研究正在被 不同人群和环境的临床需求。此外，没有一个很好的培训途径， 在这一领域的研究中，很少有职业中期和高级研究人员拥有指导职业早期的专业知识 调查人员在这一领域，并需要辅导，以增加劳动力是巨大的。最后，鉴于 在我们的领域已知的种族健康差距，这是特别重要的是，研究人员是代表的 他们所服务的人群，目前情况并非如此。我是一名医生和博士训练的行为科学家 治疗阿片类药物滥用/OUD和慢性疼痛的人。我有一个国家卫生研究院资助的 研究和富有成效的指导，在这些条件的交叉点，跨越人口和环境 包括艾滋病毒，癌症和初级保健，我在一个拥有特殊资源的机构， 实习生这个K24职业生涯中期调查员奖将使我能够在以下交叉点发展员工队伍： 阿片类药物滥用/OUD和慢性疼痛通过1）扩大我的能力，指导博士生，博士后 来自不同学科的学者和教师，让我能够继续关注女性和个人 来自在阿片类药物滥用/OUD共病研究中代表性不足的背景， 慢性疼痛; 2）成为实施科学方法研究共病治疗的领导者 阿片类药物滥用/OUD和慢性疼痛，包括混合试验;以及3）开发系统性 在我的工作中纳入健康公平考虑和研究方法。我已经召集了一个团队 我与他们一起制定了一个全面的职业发展计划，包括教学 课程作业，体验式学习和会议出席，这将使我能够在实现这些方面表现出色 目标.此外，这个K24提出了一个新的研究项目，利用现有的基于Delphi的初步 1）制定一套实施战略，以促进采用和公平适用 用于管理阿片类药物滥用/OUD和转移性癌症相关疼痛的循证方法，以及2） 对循证方法和实施战略包进行第2类混合试点试验。 这项研究的结果将导致一个混合型2随机试验的实施战略束， 最终改善阿片类药物滥用/OUD和转移性癌症患者的护理。这和其他国家卫生研究院- 在我的研究范畴内，获资助的研究项目将为学员提供充足的机会，让他们提出受导师指导的研究项目。 这种指导性的研究经验，结合量身定制的职业发展机会计划， 将在阿片类药物滥用/OUD和慢性药物滥用的交叉点上建立一个新的独立调查人员队伍。 痛苦