Mentoring the next generation of researchers at the intersection of opioid use disorder and chronic pain
指导下一代研究人员研究阿片类药物使用障碍和慢性疼痛的交叉点
基本信息
- 批准号:10663642
- 负责人:
- 金额:$ 19.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-01 至 2028-03-31
- 项目状态:未结题
- 来源:
- 关键词:Active LearningAddressAdoptedAdoptionAdvanced Malignant NeoplasmAlcoholsAreaAwardBehaviorBehavioralBuprenorphineCancer Pain ManagementClinicClinicalCocaineComplicationDataDevelopment PlansDiagnosisDisciplineDisease ManagementDisseminated Malignant NeoplasmDoctor of PhilosophyEducationEquityEvaluationFacultyFundingGoalsHIVHealthHelping to End Addiction Long-termHigh PrevalenceHybridsIndividualInstitutionInterviewLanguageLeadershipLearningLifeLife ExperienceMaintenanceMalignant NeoplasmsMapsMentorsMethadoneNeeds AssessmentOncologyOpioidOpioid agonistOutcomePainPain managementPalliative CareParticipantPathway interactionsPatient CarePatientsPerceptionPerformancePersonal SatisfactionPersonsPhysiciansPopulationPostdoctoral FellowPrimary CareProductivityPrognosisRacial EquityReach, Effectiveness, Adoption, Implementation, and MaintenanceResearchResearch MethodologyResearch PersonnelResearch Project GrantsResearch ProposalsResourcesRiskRisk FactorsScienceScientistSickle CellSpecific qualifier valueStandardizationTestingTobacco useTrainingTranslationsUnited States National Institutes of HealthWomanWorkacceptability and feasibilityaddictioncancer carecareercareer developmentcase-basedchronic abdominal painchronic painchronic pain patientclinical practicecomorbiditydata submissiondesigndoctoral studenteffectiveness outcomeeffectiveness/implementation hybridevidence baseevidence based guidelinesexperiencehealth equityhybrid type 2 trialimplementation barriersimplementation evaluationimplementation facilitatorsimplementation frameworkimplementation protocolimplementation scienceimplementation strategyimprovedmedication for opioid use disordernext generationnovelopioid misuseopioid overdoseopioid use disorderpilot trialprescription opioidprogramsracial disparityracial health disparityrandomized trialrecruitresearch to practiceskillssocial stigmasubstance usesymposiumsystematic reviewtreatment optimizationtreatment research
项目摘要
Project Summary/Abstract: My overall goal is to improve the health and well-being of individuals with
comorbid opioid misuse/opioid use disorder (OUD) and chronic pain across varied settings and populations.
Research on the management of comorbid opioid misuse/OUD and chronic pain is being outpaced by the
clinical need across populations and settings. Additionally, there is no well-worn training pathway to conduct
research in this area, few mid-career and senior investigators have the expertise to mentor early-career
investigators in this space, and the need for mentoring to grow the workforce is enormous. Finally, given the
known racial health disparities in our field, it is especially important that researchers are representative of the
populations they serve, which is currently not the case. I am a physician and PhD-trained behavioral scientist
who treats individuals with opioid misuse/OUD and chronic pain. I have a consistent track record of NIH-funded
research and productive mentoring at the intersection of these conditions across populations and settings
including HIV, cancer, and primary care, and am at an institution with exceptional resources to support
trainees. This K24 mid-career investigator award will allow me to grow the workforce at the intersection of
opioid misuse/OUD and chronic pain by 1) expanding my capacity to mentor PhD students, postdoctoral
scholars, and faculty from diverse disciplines—and allow me to continue to focus on women and individuals
from backgrounds that are underrepresented in science—in research on comorbid opioid misuse/OUD and
chronic pain; 2) Become a leader in implementation science approaches to studying treatment of comorbid
opioid misuse/OUD and chronic pain, including hybrid trials; and 3) Develop the skills needed to systematically
incorporate health equity considerations and research methods throughout my work. I have assembled a team
of advisors with whom I have created a comprehensive career development plan including didactic
coursework, experiential learning, and conference attendance that will allow me to excel at achieving these
goals. Additionally, this K24 proposes a new research project that leverages existing Delphi-based preliminary
data to 1) Develop an implementation strategy bundle to promote the adoption and equitable application of
evidence-based approaches for managing opioid misuse/OUD and metastatic cancer-related pain, and 2)
Conduct a hybrid type 2 pilot trial of the evidence-based approaches and implementation strategy bundle.
Findings from this study will lead to a hybrid type 2 randomized trial of the implementation strategy bundle and
ultimately improved care for patients with opioid misuse/OUD and metastatic cancer. This and other NIH-
funded studies in my portfolio will provide mentees ample opportunity to propose mentored research projects.
This mentored research experience, combined with a program of tailored career development opportunities,
will develop a new cadre of independent investigators at the intersection of opioid misuse/OUD and chronic
pain.
项目摘要/摘要:我的总体目标是改善患有以下疾病的个人的健康和福祉
不同环境和人群中的共病阿片类药物滥用/阿片类药物使用障碍 (OUD) 和慢性疼痛。
对共病阿片类药物滥用/OUD 和慢性疼痛的管理研究正在被超越
跨人群和环境的临床需求。此外,没有陈旧的培训途径来进行
在这一领域的研究中,很少有职业中期和高级研究人员拥有指导职业早期的专业知识
这个领域的研究人员,并且对指导以扩大劳动力的需求是巨大的。最后,鉴于
由于我们领域已知的种族健康差异,研究人员代表该领域尤为重要
他们所服务的人群,但目前情况并非如此。我是一名医生和受过博士学位训练的行为科学家
他治疗阿片类药物滥用/OUD 和慢性疼痛的患者。我有 NIH 资助的一贯记录
针对跨人群和环境的这些条件的交叉点进行研究和富有成效的指导
包括艾滋病毒、癌症和初级保健,并且我所在的机构拥有特殊的资源来支持
实习生。这个 K24 职业生涯中期调查员奖将使我能够在以下领域扩大员工队伍:
阿片类药物滥用/OUD 和慢性疼痛,方法是 1) 扩大我指导博士生、博士后的能力
来自不同学科的学者和教师,让我能够继续关注女性和个人
来自科学界代表性不足的背景——在共病阿片类药物滥用/OUD 的研究中,
慢性疼痛; 2) 成为研究共病治疗的实施科学方法的领导者
阿片类药物滥用/OUD 和慢性疼痛,包括混合试验; 3) 培养系统地开展工作所需的技能
在我的工作中融入健康公平的考虑和研究方法。我已经组建了一个团队
我与顾问一起制定了全面的职业发展计划,包括教学
课程作业、体验式学习和参加会议将使我能够出色地实现这些目标
目标。此外,本 K24 提出了一个新的研究项目,该项目利用现有的基于 Delphi 的初步研究
数据以 1) 制定实施策略包,以促进采用和公平应用
用于管理阿片类药物滥用/OUD 和转移性癌症相关疼痛的循证方法,以及 2)
对循证方法和实施策略包进行混合 2 类试点试验。
这项研究的结果将导致实施策略包的混合 2 型随机试验和
最终改善了对阿片类药物滥用/OUD 和转移性癌症患者的护理。这个和其他 NIH-
我的投资组合中受资助的研究将为受指导者提供充足的机会来提出受指导的研究项目。
这种指导性的研究经验与量身定制的职业发展机会计划相结合,
将在阿片类药物滥用/OUD 和慢性病交叉领域培养一支新的独立调查员队伍
疼痛。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jessica S Merlin其他文献
An Observational Study of Dialogue about Uncertainty in Clinician-Family Counseling Conversations Following Prenatal Diagnosis of Complex Congenital Heart Disease
复杂先天性心脏病产前诊断后临床医生与家庭咨询对话中不确定性的观察研究
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Kelly W. Harris;Kelsey Schweiberger;Ann Kavanaugh;Robert M. Arnold;Jessica S Merlin;Judy C. Chang;N. A. Kasparian - 通讯作者:
N. A. Kasparian
Jessica S Merlin的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jessica S Merlin', 18)}}的其他基金
Opioid therapy for pain in individuals with metastatic cancer: benefits, harms and stakeholder perspectives
阿片类药物治疗转移性癌症患者的疼痛:益处、危害和利益相关者的观点
- 批准号:
10280057 - 财政年份:2021
- 资助金额:
$ 19.26万 - 项目类别:
Opioid therapy for pain in individuals with metastatic cancer: benefits, harms and stakeholder perspectives
阿片类药物治疗转移性癌症患者的疼痛:益处、危害和利益相关者的观点
- 批准号:
10670405 - 财政年份:2021
- 资助金额:
$ 19.26万 - 项目类别:
Consensus-based algorithms to address opioid misuse behaviors among individuals prescribed long-term opioid therapy: developing implementation strategies and pilot testing
基于共识的算法,用于解决接受长期阿片类药物治疗的个体中阿片类药物滥用行为:制定实施策略和试点测试
- 批准号:
10405067 - 财政年份:2020
- 资助金额:
$ 19.26万 - 项目类别:
Consensus-based algorithms to address opioid misuse behaviors among individuals prescribed long-term opioid therapy: developing implementation strategies and pilot testing
基于共识的算法,用于解决接受长期阿片类药物治疗的个体中阿片类药物滥用行为:制定实施策略和试点测试
- 批准号:
10202542 - 财政年份:2020
- 资助金额:
$ 19.26万 - 项目类别:
Consensus-based algorithms to address opioid misuse behaviors among individuals prescribed long-term opioid therapy: developing implementation strategies and pilot testing
基于共识的算法,用于解决接受长期阿片类药物治疗的个体中阿片类药物滥用行为:制定实施策略和试点测试
- 批准号:
10055996 - 财政年份:2020
- 资助金额:
$ 19.26万 - 项目类别:
Evaluation of the efficacy and mechanisms of a novel intervention for chronic pain tailored to people living with HIV
评估针对艾滋病毒感染者量身定制的慢性疼痛新型干预措施的功效和机制
- 批准号:
10397398 - 财政年份:2018
- 资助金额:
$ 19.26万 - 项目类别:
Evaluation of the efficacy and mechanisms of a novel intervention for chronic pain tailored to people living with HIV
评估针对艾滋病毒感染者量身定制的慢性疼痛新型干预措施的功效和机制
- 批准号:
9922384 - 财政年份:2018
- 资助金额:
$ 19.26万 - 项目类别:
Development of a Behavioral Intervention for Chronic Pain in Individuals with HIV
开发针对艾滋病毒感染者慢性疼痛的行为干预措施
- 批准号:
9180066 - 财政年份:2014
- 资助金额:
$ 19.26万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 19.26万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 19.26万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 19.26万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 19.26万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 19.26万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 19.26万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 19.26万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 19.26万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 19.26万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 19.26万 - 项目类别:
Research Grant














{{item.name}}会员




