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PrEP US NoW: PrEP Utilization Through Increasing Social Capital Among YBMSM Networks with Women

PrEP 现在美国：通过增加 YBMSM 女性网络中的社会资本来利用 PrEP

基本信息

批准号：
10663087
负责人：
Latesha Ellen Elopre
金额：
$ 19.62万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-23 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10663087
关键词：
AIDS prevention Access to Information Acquired Immunodeficiency Syndrome Address Adoption Affect Alabama Attitude Behavior Belief Black American Caring Charge Communication Complex Data Development Disparity Disparity population Elements Emotional Epidemic Feedback Financial Support Funding Geography Guidelines HIV HIV diagnosis HIV/AIDS Health Health Promotion Health behavior Human immunodeficiency virus test Individual Inequity Intervention Interview Knowledge Link Maps Measurement Measures Mobile Health Application Modeling Motivation Newly Diagnosed Outcome Participant Population Prevention Prevention approach Prevention strategy Process Public Health Randomized Randomized, Controlled Trials Research Research Priority Resources Respondent Risk Role Sampling Services Sexual Health Site Social Network Social support Source Strategic Planning Structure Surveys Techniques Testing Time Training United States United States National Institutes of Health Woman Work acceptability and feasibility arm black men who have sex with men black women comparative condomless anal sex effective intervention efficacy trial epidemic preparedness evidence base homonegativity improved insight instrument intervention mapping mHealth member mobile application novel novel strategies pilot trial pre-exposure prophylaxis programs recruit response scale up sexual identity social capital social norm social stigma tool treatment arm uptake usability virtual

项目摘要

PROJECT SUMMARY HIV, especially in the South, disproportionately affects young Black men who have sex with men (YBMSM). Development and implementation of effective interventions to scale up HIV pre-exposure prophylaxis (PrEP) are urgently needed in this population. Prior work has focused on individual-level approaches to increasing PrEP utilization, while social network-level approaches are comparatively underutilized. Individuals within social networks have access to social capital, which can yield emotional as well as instrumental resources that influence health behaviors. Black women represent a key source of social capital within YBMSM social networks, and this unique role has not been utilized in prior PrEP interventions. We propose to leverage YBMSM’s supportive connections with Black women to develop PrEP US NoW (PrEP Utilization through increasing Social Capital among YBMSM Networks with Women), a novel mobile health intervention that will engage Black women as facilitators in existing networks of YBMSM, as a way of enhancing social capital, decreasing intersectional stigma, and promoting PrEP uptake within the network. The proposal will pursue three specific aims: (1) Qualitatively evaluate core health-promoting elements of social capital bonds between YBMSM and Black women in extant social support networks; (2) Adapt an existing, evidence-based mHealth intervention to create PrEP US NoW; and (3) Evaluate feasibility and acceptability of PrEP US NoW, as well as preliminary efficacy to increase PrEP uptake among YBMSM, in a randomized-controlled pilot trial. For Aim 1, we will conduct qualitative interviews with n=20 YBMSM and n=20 Black women to gain insights into preferred attributes of Black woman facilitators, as well as feedback on intervention content and format. In Aim 2, we will develop the PrEP US NoW mobile app. The central feature of the PrEP US NoW intervention will be real-time, virtual discussions led by a trained Black woman facilitator, delivered to an existing network of YBMSM. Additional features and content will be refined based on our Aim 1 findings. We will conduct usability testing in an iterative process with both YBMSM and Black women. In Aim 3, we will randomize YBMSM networks (up to five members each), recruited using respondent driven sampling techniques, to the intervention (PrEP US NoW) or control study arm (mHealth app without social capital components). Participants (N=60) will complete validated surveys measuring social capital, internalized homonegativity, and PrEP uptake at baseline, 1-month, and at 3-months’ time. HIV testing will be done at baseline and at 3-months’ time. We will assess feasibility, acceptability, and preliminary efficacy. This study will be conducted in an epicenter of the Southern HIV epidemic: Alabama. Upon completion of our aims, we will have collected requisite preliminary data to inform a fully powered multi-site efficacy trial. The proposed research has strong potential to inform effective HIV prevention strategies among YBMSM in the South, leading to improved individual and public health outcomes aligned with national initiatives.

项目总结