CAMELLIA Cohort: A longitudinal study to understand sexual health and prevention among women in Alabama
CAMELLIA 队列:一项了解阿拉巴马州女性性健康和预防的纵向研究
基本信息
- 批准号:10701932
- 负责人:
- 金额:$ 121.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-08 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS preventionAcquired Immunodeficiency SyndromeAddressAdherenceAgeAlabamaAlgorithmsAreaAwarenessBehavioralBlack AmericanBlack raceBloodCamellia sinensisCaringChlamydiaCollaborationsColorCommunitiesCountyDataData SourcesDeep SouthDevelopmentDiagnosisDisparityDrynessElementsEligibility DeterminationEnrollmentEpidemicEpidemiologyEvidence based interventionExposure toFlowersFundingFunding OpportunitiesFutureGeographyGoalsGonorrheaHIVHIV InfectionsHIV diagnosisHIV riskHigh Risk WomanHispanicHispanic AmericansHomeHuman immunodeficiency virus testIncidenceIndividualInequityInfectionInstitutionalizationInterviewLongitudinal StudiesMediatorMedical RecordsMethodologyMobile Health ApplicationMonitorNamesNational Institute of Allergy and Infectious DiseaseNorth CarolinaOutcomeOutcome StudyPatient Self-ReportPersonsPopulationPovertyPreventionProcessPublic HealthRecording of previous eventsResearchResearch PersonnelResearch ProposalsRiskRuralSamplingSexual HealthSexually Transmitted DiseasesSpottingsSurveysSyphilisSyphilis SerodiagnosisSystemTechniquesTestingUnited StatesUniversitiesWomanacceptability and feasibilityblack men who have sex with menblack womencis-femalecohortcommunity engaged researchdesigndigitaldigital platformepidemiologic dataevidence baseexperiencehigh riskhome testimprovedinnovationmembermultidisciplinarynovelpopulation basedpre-exposure prophylaxisprevention serviceprimary outcomeprogramsracismrecruitsocialsocial disparitiestherapy developmenttooltransgender womentrenduptakeusabilitywomen of color
项目摘要
Abstract
Despite the availability of effective HIV prevention tools such as pre-exposure prophylaxis (PrEP), significant
disparities persist among communities of color, particularly among women in the Deep South where the rate of
HIV infection is fourteen-times higher for Black women compared to White women. PrEP utilization remains
low among women in the Deep South with estimates of <7% eligible women receiving PrEP in Alabama.
Moreover, algorithms to determine PrEP eligibility demonstrate poor predictive power for women. The proposal
takes advantage of a dynamic and innovative collaboration of experienced HIV-prevention investigators from
the University of Alabama-Birmingham, University of North Carolina-Chapel Hill, Centers for AIDS Research,
the Alabama Department of Public Health (ADPH), and Social Scientific Systems. This novel research
proposal utilizes a population-based approach to establish a geographically representative cohort of cis- and
trans-gender women (‘Camellia Cohort’) at significant risk for future HIV acquisition, based on recent
gonorrhea or syphilis infection, across the state of Alabama (AL), highlighted as a geographic hotspot by the
federal Ending the HIV Epidemic strategy, to better understand factors associated with risk of STI and HIV
diagnosis and predictors for PrEP use. The aims of this proposal are to: 1) refine the HealthMpowerment
(HMP) digital platform, previously utilized to deliver evidence-based interventions to improve HIV and
prevention outcomes among Black men who have sex with men and transgender women, to include key
elements that optimally engage and retain a cohort of women at-risk for HIV in AL; this will be achieved via
stakeholder engaged research with self-identified women on PrEP and PrEP care team members using
nominal group techniques; 2) recruit and retain a geographically-diverse and rurally-enhanced cohort of 800
women ages 18-44, with recent positive gonorrhea or syphilis testing who are STI- and HIV-uninfected at
enrollment, to participate in the Camellia digital cohort utilizing a geographically diverse sampling framework
using public and commercially available annual county-level HIV and STI testing data and 3) evaluate
predictors, mediators and moderators for STI/HIV incidence and PrEP use and adherence in the Camellia
Cohort by collecting demographic, behavioral, and community level assessments via the HMP digital platform
and HIV/STI testing through ADPH’s home testing program at regular intervals; we will purposefully sample
women with high HIV vulnerability and/or PrEP use within the cohort for in-depth interviews (n = 30) to further
explore factors contributing to PrEP use to guide future intervention development. This research will lay the
groundwork for a larger research program testing the implementation of a further adapted HMP digital platform
designed to improve HIV/STI testing, PrEP utilization and persistence among women in the Deep South,
focusing on areas with higher HIV incidence.
摘要
尽管有有效的艾滋病毒预防工具,如暴露前预防(PrEP),但显著
有色人种群体之间的差异依然存在,特别是在南方腹地的妇女中,那里的
黑人女性的艾滋病毒感染率是白人女性的14倍。准备使用率保持不变
在南方腹地的女性中比例很低,据估计,阿拉巴马州有7%的合格女性接受PrEP。
此外,确定PrEP资格的算法对女性的预测能力很差。这项建议
利用经验丰富的艾滋病毒预防研究人员的动态和创新合作
阿拉巴马大学伯明翰分校,北卡罗来纳大学教堂山分校,艾滋病研究中心,
阿拉巴马州公共卫生部(ADPH)和社会科学系统。这项新奇的研究
建议利用以人口为基础的方法来建立具有地理代表性的顺位-和
根据最近的研究,跨性别者女性(‘Camellia Cohort’)未来感染艾滋病毒的风险很大
淋病或梅毒感染,横跨阿拉巴马州(AL),被强调为地理热点
联邦终止艾滋病毒流行战略,以更好地了解与性传播感染和艾滋病毒风险相关的因素
PrEP使用的诊断和预测指标。这项提议的目的是:1)完善医疗授权
(HMP)数字平台,以前用于提供循证干预措施,以改善艾滋病毒和
黑人男男性行为者和变性人女性的预防结果,包括关键
以最佳方式吸引和留住AL中艾滋病毒高危人群的要素;这将通过以下方式实现
利益相关者参与了关于PrEP的自我认同女性的研究,PrEP护理团队成员使用
名义上的群体技术;2)招募和保留800人的地理多样化和乡村增强的队列
18-44岁的女性,最近淋病或梅毒检测呈阳性,但未感染STI和HIV
登记,参加Camellia数字队列,利用地理上多样化的抽样框架
使用公共和商业可用的县级艾滋病毒和性传播感染年度检测数据和3)评估
山茶花中STI/HIV发病率和PrEP使用和依从性的预测、调节和调节因素
通过HMP数字平台收集人口统计、行为和社区级别的评估
通过ADPH的家庭检测计划定期进行艾滋病毒/性传播感染检测;我们将有目的地抽样
艾滋病毒易感性高和/或在队列中使用PrEP的妇女进行深入访谈(n=30),以进一步
探索影响PrEP使用的因素,以指导未来的干预发展。这项研究将为
为测试进一步调整的HMP数字平台的实施情况的更大研究方案奠定基础
旨在改善艾滋病毒/性传播感染检测、PrEP使用率和南方腹地妇女的持久性,
重点关注艾滋病毒发病率较高的地区。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Latesha Ellen Elopre其他文献
Latesha Ellen Elopre的其他文献
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{{ truncateString('Latesha Ellen Elopre', 18)}}的其他基金
CAMELLIA Cohort: A longitudinal study to understand sexual health and prevention among women in Alabama
CAMELLIA 队列:一项了解阿拉巴马州女性性健康和预防的纵向研究
- 批准号:
10538855 - 财政年份:2022
- 资助金额:
$ 121.12万 - 项目类别:
PrEP US NoW: PrEP Utilization Through Increasing Social Capital Among YBMSM Networks with Women
PrEP 现在美国:通过增加 YBMSM 女性网络中的社会资本来利用 PrEP
- 批准号:
10325097 - 财政年份:2021
- 资助金额:
$ 121.12万 - 项目类别:
PrEP Pro: Adapting a multi-component intervention to train and support providers to promote PrEP for adolescent girls and young women in the Deep South
PrEP Pro:采用多成分干预措施来培训和支持提供者,以促进南部腹地少女和年轻女性的 PrEP
- 批准号:
10663866 - 财政年份:2021
- 资助金额:
$ 121.12万 - 项目类别:
PrEP 4 Her: Developing a Novel Strategy to Implement PrEP into Women's Healthcare
PrEP 4 Her:制定新策略将 PrEP 实施到女性医疗保健中
- 批准号:
10682433 - 财政年份:2021
- 资助金额:
$ 121.12万 - 项目类别:
PrEP Pro: Adapting a multi-component intervention to train and support providers to promote PrEP for adolescent girls and young women in the Deep South
PrEP Pro:采用多成分干预措施来培训和支持提供者,以促进南部腹地少女和年轻女性的 PrEP
- 批准号:
10469666 - 财政年份:2021
- 资助金额:
$ 121.12万 - 项目类别:
PrEP 4 Her: Developing a Novel Strategy to Implement PrEP into Women's Healthcare
PrEP 4 Her:制定将 PrEP 纳入女性医疗保健的新策略
- 批准号:
10469513 - 财政年份:2021
- 资助金额:
$ 121.12万 - 项目类别:
PrEP Pro: Adapting a multi-component intervention to train and support providers to promote PrEP for adolescent girls and young women in the Deep South
PrEP Pro:采用多成分干预措施来培训和支持提供者,以促进南部腹地少女和年轻女性的 PrEP
- 批准号:
10327906 - 财政年份:2021
- 资助金额:
$ 121.12万 - 项目类别:
PrEP 4 Her: Developing a Novel Strategy to Implement PrEP into Women's Healthcare
PrEP 4 Her:制定新策略将 PrEP 实施到女性医疗保健中
- 批准号:
10327443 - 财政年份:2021
- 资助金额:
$ 121.12万 - 项目类别:
PrEP US NoW: PrEP Utilization Through Increasing Social Capital Among YBMSM Networks with Women
PrEP 现在美国:通过增加 YBMSM 女性网络中的社会资本来利用 PrEP
- 批准号:
10663087 - 财政年份:2021
- 资助金额:
$ 121.12万 - 项目类别:
PrEP US NoW: PrEP Utilization Through Increasing Social Capital Among YBMSM Networks with Women
PrEP 现在美国:通过增加 YBMSM 女性网络中的社会资本来利用 PrEP
- 批准号:
10456206 - 财政年份:2021
- 资助金额:
$ 121.12万 - 项目类别:
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