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CAMELLIA Cohort: A longitudinal study to understand sexual health and prevention among women in Alabama

CAMELLIA 队列：一项了解阿拉巴马州女性性健康和预防的纵向研究

基本信息

批准号：
10701932
负责人：
Latesha Ellen Elopre
金额：
$ 121.12万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-08 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10701932
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Address Adherence Age Alabama Algorithms Area Awareness Behavioral Black American Black race Blood Camellia sinensis Caring Chlamydia Collaborations Color Communities County Data Data Sources Deep South Development Diagnosis Disparity Dryness Elements Eligibility Determination Enrollment Epidemic Epidemiology Evidence based intervention Exposure to Flowers Funding Funding Opportunities Future Geography Goals Gonorrhea HIV HIV Infections HIV diagnosis HIV risk High Risk Woman Hispanic Hispanic Americans Home Human immunodeficiency virus test Incidence Individual Inequity Infection Institutionalization Interview Longitudinal Studies Mediator Medical Records Methodology Mobile Health Application Monitor Names National Institute of Allergy and Infectious Disease North Carolina Outcome Outcome Study Patient Self-Report Persons Population Poverty Prevention Process Public Health Recording of previous events Research Research Personnel Research Proposals Risk Rural Sampling Sexual Health Sexually Transmitted Diseases Spottings Surveys Syphilis Syphilis Serodiagnosis System Techniques Testing United States Universities Woman acceptability and feasibility black men who have sex with men black women cis-female cohort community engaged research design digital digital platform epidemiologic data evidence base experience high risk home test improved innovation member multidisciplinary novel population based pre-exposure prophylaxis prevention service primary outcome programs racism recruit social social disparities therapy development tool transgender women trend uptake usability women of color

项目摘要

Abstract Despite the availability of effective HIV prevention tools such as pre-exposure prophylaxis (PrEP), significant disparities persist among communities of color, particularly among women in the Deep South where the rate of HIV infection is fourteen-times higher for Black women compared to White women. PrEP utilization remains low among women in the Deep South with estimates of <7% eligible women receiving PrEP in Alabama. Moreover, algorithms to determine PrEP eligibility demonstrate poor predictive power for women. The proposal takes advantage of a dynamic and innovative collaboration of experienced HIV-prevention investigators from the University of Alabama-Birmingham, University of North Carolina-Chapel Hill, Centers for AIDS Research, the Alabama Department of Public Health (ADPH), and Social Scientific Systems. This novel research proposal utilizes a population-based approach to establish a geographically representative cohort of cis- and trans-gender women (‘Camellia Cohort’) at significant risk for future HIV acquisition, based on recent gonorrhea or syphilis infection, across the state of Alabama (AL), highlighted as a geographic hotspot by the federal Ending the HIV Epidemic strategy, to better understand factors associated with risk of STI and HIV diagnosis and predictors for PrEP use. The aims of this proposal are to: 1) refine the HealthMpowerment (HMP) digital platform, previously utilized to deliver evidence-based interventions to improve HIV and prevention outcomes among Black men who have sex with men and transgender women, to include key elements that optimally engage and retain a cohort of women at-risk for HIV in AL; this will be achieved via stakeholder engaged research with self-identified women on PrEP and PrEP care team members using nominal group techniques; 2) recruit and retain a geographically-diverse and rurally-enhanced cohort of 800 women ages 18-44, with recent positive gonorrhea or syphilis testing who are STI- and HIV-uninfected at enrollment, to participate in the Camellia digital cohort utilizing a geographically diverse sampling framework using public and commercially available annual county-level HIV and STI testing data and 3) evaluate predictors, mediators and moderators for STI/HIV incidence and PrEP use and adherence in the Camellia Cohort by collecting demographic, behavioral, and community level assessments via the HMP digital platform and HIV/STI testing through ADPH’s home testing program at regular intervals; we will purposefully sample women with high HIV vulnerability and/or PrEP use within the cohort for in-depth interviews (n = 30) to further explore factors contributing to PrEP use to guide future intervention development. This research will lay the groundwork for a larger research program testing the implementation of a further adapted HMP digital platform designed to improve HIV/STI testing, PrEP utilization and persistence among women in the Deep South, focusing on areas with higher HIV incidence.

摘要