Approaches to Studying Social Motivation in Schizophrenia

人类是高度社会化的生物，有动机去寻找、参与和维持人际关系。 与他人的关系。这种基本的人类驱动力被称为社会动机。然而，退伍军人 精神分裂症患者的社会动机经常受到干扰，导致社会功能低下。 目前的循证治疗在改善社会动机障碍方面并不足够有效 退伍军人精神分裂症患者为了告知新的治疗开发，新的实验方法是 需要一个更全面的了解这个普遍存在的问题。现时的建议 采用了美国国立卫生研究院（NIMH）研究的社会动机理论框架 领域标准（RDoC），它将社会动机分为两个主要组成部分：社会关注和社会 记忆社会关注是指优先关注环境的社会方面的偏见， 包括注意力捕捉和持续注意力的阶段。社会记忆指的是记忆的能力 我们与谁互动，以建立和维持关系，并涉及记忆编码的阶段， 检索目前尚不清楚退伍军人社会动机障碍开始出现的阶段， 精神分裂症此外，这两个社会动机成分对社会的相对贡献 功能尚不清楚。精神分裂症的社会功能传统上是通过临床医生- 评级访谈，这在理解现实世界社会功能的复杂性方面具有有限的特异性。 本提案的总体目标是阐明这两种社会动机的相对贡献 成分（社会注意力和社会记忆）及其在现实社会中的具体处理阶段 在退伍军人精神分裂症患者中发挥作用该提案采用了创新的多模式方法， 阐明了处理阶段与脑电图（EEG），和现实世界的社会功能与 通过智能手机技术进行数字表型分析。这项研究的结果有可能推动我们的 了解精神分裂症的社会动机，并确定具体的治疗目标， 退伍军人事务部因这种令人衰弱的疾病而产生的费用和负担。 除了解决上述研究目标，这个职业发展奖（CDA）将提供 申请人Lauren T. Catalano博士，在以下领域接受过培训：（1）社会领域的翻译研究 精神分裂症和社会动机的神经科学;（2）先进的脑电图（EEG）技术; 和（3）通过移动的智能手机技术进行数字表型分析。申请人的职业目标是成为VA- 基于心理学临床研究人员，致力于改善退伍军人所经历的社会残疾， 严重的精神疾病。本CDA申请中概述的培训将为申请人奠定基础， 在退伍军人事务部内开展一项独立的研究计划，重点关注精神分裂症的社会动机。的 VISN 22精神疾病研究，教育和临床中心（MIRECC）在VA大洛杉矶 医疗保健系统（GLA）和加州大学洛杉矶分校（UCLA）提供了一个优秀的 环境和基础设施，以完成拟议的研究。主要导师将是迈克尔F。绿色， 博士，VISN 22 MIRECC治疗中心主任，VA研究增强奖主任 计划（REAP）为加强无家可归的退伍军人的社区融合，和一个既定的研究员 精神分裂症领域的研究申请人还将接受脑电图专家的专门培训 方法在退伍军人与严重的精神疾病（乔纳森K。Wynn博士），也是移动的领域的领先专家 严重精神疾病退伍军人的评估方法（埃里克L。Granholm，PhD）。

Humans are highly social beings that are motivated to seek out, engage in, and maintain interpersonal relationships with others. This fundamental human drive is referred to as social motivation. However, Veterans with schizophrenia often experience disruptions in social motivation, resulting in poor social functioning. Current evidence-based treatments are not sufficiently effective at improving impairments in social motivation in Veterans with schizophrenia. To inform novel treatment development, new experimental approaches are needed that will generate a more complete understanding of this pervasive problem. The current proposal adapts a theoretical framework of social motivation from the National Institutes of Health (NIMH) Research Domain Criteria (RDoC), which parses social motivation into two major components: social attention and social memory. Social attention refers to the bias to preferentially attend to social aspects of the environment, and involves stages of attention capture and sustained attention. Social memory refers to the ability to remember who we interacted with to establish and maintain relationships, and involves stages of memory encoding and retrieval. It is not clear the stage at which social motivation impairments begin to emerge for Veterans with schizophrenia. Additionally, the relative contribution of these two social motivation components on social functioning is not known. Social functioning in schizophrenia has traditionally been assessed using clinician- rated interviews, which has limited specificity in understanding the complexities of real-world social functioning. The overall goal of this proposal is to elucidate the relative contribution of the two social motivation components (social attention and social memory) and their specific stages of processing on real-world social functioning in Veterans with schizophrenia. The proposal utilizes an innovative multi-modal approach that elucidates stages of processing with electroencephalography (EEG), and real-world social functioning with digital phenotyping via smartphone technology. The results of this study have the potential to advance our understanding of social motivation in schizophrenia and to identify specific treatment targets that will reduce the cost and burden associated with this debilitating disorder at the VA. In addition to addressing the above research goals, this Career Development Award (CDA) will provide the applicant, Lauren T. Catalano, PhD, with the training in the areas of: (1) translational research in the social neuroscience of schizophrenia and social motivation; (2) advanced electroencephalography (EEG) techniques; and (3) digital phenotyping via mobile smartphone technology. The applicant’s career goal is to become a VA- based psychology clinician researcher, working to improve the social disability experienced by Veterans with serious mental illness. The training outlined in this CDA application will lay the groundwork for the applicant to develop an independent research program within the VA focused on social motivation in schizophrenia. The VISN 22 Mental Illness Research, Education, and Clinical Center (MIRECC) at the VA Greater Los Angeles Healthcare System (GLA), and the University of California, Los Angeles (UCLA) provides an excellent environment and infrastructure to complete the proposed study. The primary mentor will be Michael F. Green, PhD, the Director of the VISN 22 MIRECC Treatment Unit, Director of the VA Research Enhancement Award Program (REAP) for Enhancing Community Integration in Homeless Veterans, and an established researcher in the field of schizophrenia. The applicant will also receive specialized training from an expert in EEG methodology in Veterans with serious mental illness (Jonathan K. Wynn, PhD), and a leading expert in mobile assessment methodology in Veterans with serious mental illness (Eric L. Granholm, PhD).