Approaches to Studying Social Motivation in Schizophrenia

研究精神分裂症社会动机的方法

基本信息

批准号：
10663065
负责人：
Lauren Theresa Catalano
金额：
--
依托单位：
VA GREATER LOS ANGELES HEALTHCARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10663065
关键词：
Acute Address Affect Area Attention Award Budgets California Cellular Phone Community Integration Consensus Cues Delusions Detection Disease Doctor of Philosophy Ecological momentary assessment Education Electroencephalography Environment Event-Related Potentials Evidence based treatment Global Positioning System Goals Grain Hallucinations Health system Healthcare Healthcare Systems Home Homelessness Human Impairment Infrastructure Interpersonal Relations Intervention Interview K-Series Research Career Programs Knowledge Los Angeles Measures Memory Mental disorders Mentors Methodology Methods Modernization Motivation National Institute of Mental Health Patient Self-Report Patients Pattern Phenotype Process Psychology Public Health Recovery Reporting Research Research Domain Criteria Research Personnel Retrieval Schizophrenia Services Social Functioning Social Interaction Specificity Stimulus Techniques Technology Time Training Translational Research United States National Institutes of Health Universities Veterans Work career clinical center cost digital disability experience functional disability improved indexing innovation member memory encoding memory recognition memory retrieval multimodality neural novel pharmacologic phenotypic data preference programs psychotic symptoms severe mental illness smartphone based assessment social social attention social influence social learning social neuroscience sustained attention temporal measurement therapy development treatment center

项目摘要

Humans are highly social beings that are motivated to seek out, engage in, and maintain interpersonal relationships with others. This fundamental human drive is referred to as social motivation. However, Veterans with schizophrenia often experience disruptions in social motivation, resulting in poor social functioning. Current evidence-based treatments are not sufficiently effective at improving impairments in social motivation in Veterans with schizophrenia. To inform novel treatment development, new experimental approaches are needed that will generate a more complete understanding of this pervasive problem. The current proposal adapts a theoretical framework of social motivation from the National Institutes of Health (NIMH) Research Domain Criteria (RDoC), which parses social motivation into two major components: social attention and social memory. Social attention refers to the bias to preferentially attend to social aspects of the environment, and involves stages of attention capture and sustained attention. Social memory refers to the ability to remember who we interacted with to establish and maintain relationships, and involves stages of memory encoding and retrieval. It is not clear the stage at which social motivation impairments begin to emerge for Veterans with schizophrenia. Additionally, the relative contribution of these two social motivation components on social functioning is not known. Social functioning in schizophrenia has traditionally been assessed using clinician- rated interviews, which has limited specificity in understanding the complexities of real-world social functioning. The overall goal of this proposal is to elucidate the relative contribution of the two social motivation components (social attention and social memory) and their specific stages of processing on real-world social functioning in Veterans with schizophrenia. The proposal utilizes an innovative multi-modal approach that elucidates stages of processing with electroencephalography (EEG), and real-world social functioning with digital phenotyping via smartphone technology. The results of this study have the potential to advance our understanding of social motivation in schizophrenia and to identify specific treatment targets that will reduce the cost and burden associated with this debilitating disorder at the VA. In addition to addressing the above research goals, this Career Development Award (CDA) will provide the applicant, Lauren T. Catalano, PhD, with the training in the areas of: (1) translational research in the social neuroscience of schizophrenia and social motivation; (2) advanced electroencephalography (EEG) techniques; and (3) digital phenotyping via mobile smartphone technology. The applicant’s career goal is to become a VA- based psychology clinician researcher, working to improve the social disability experienced by Veterans with serious mental illness. The training outlined in this CDA application will lay the groundwork for the applicant to develop an independent research program within the VA focused on social motivation in schizophrenia. The VISN 22 Mental Illness Research, Education, and Clinical Center (MIRECC) at the VA Greater Los Angeles Healthcare System (GLA), and the University of California, Los Angeles (UCLA) provides an excellent environment and infrastructure to complete the proposed study. The primary mentor will be Michael F. Green, PhD, the Director of the VISN 22 MIRECC Treatment Unit, Director of the VA Research Enhancement Award Program (REAP) for Enhancing Community Integration in Homeless Veterans, and an established researcher in the field of schizophrenia. The applicant will also receive specialized training from an expert in EEG methodology in Veterans with serious mental illness (Jonathan K. Wynn, PhD), and a leading expert in mobile assessment methodology in Veterans with serious mental illness (Eric L. Granholm, PhD).

人类是高度社会的生物，有动力寻找，参与人际关系与他人的关系。这种基本的人类驱动力被称为社会动机。但是，退伍军人精神分裂症经常在社会动机中遭受中断，导致社会功能不佳。当前的基于证据的治疗在改善社会动机的损害方面没有足够的有效在精神分裂症的退伍军人中。为了告知新的治疗开发，新的实验方法是需要，这将对这个普遍的问题产生更完整的理解。当前的建议改编国立卫生研究院（NIMH）研究的社会动机理论框架领域标准（RDOC），将社会动机解析为两个主要组成部分：社会关注和社会记忆。社会关注是指优选地参与环境的社会方面的偏见，并且涉及关注的阶段和持续关注。社交记忆是指记住的能力我们与谁进行互动以建立和维持关系，涉及记忆编码的阶段和检索。目前尚不清楚社交动机障碍开始为退伍军人带来的阶段精神分裂症。此外，这两个社会动机组成部分对社会的相对贡献功能尚不清楚。传统上，精神分裂症的社会功能是使用临床评估的评分的访谈在理解现实世界社会功能的复杂性方面的特殊性有限。该提案的总体目标是阐明两个社会动机的相对贡献组成部分（社会关注和社交记忆）及其在现实世界中处理的具体阶段在精神分裂症的退伍军人中发挥作用。该提案利用一种创新的多模式方法通过脑电图（EEG）阐明处理的阶段，以及现实世界的社会功能通过智能手机技术进行数字表型。这项研究的结果有可能进步了解精神分裂症中的社会动机，并确定将减少的特定治疗目标 VA的这种使人衰弱的障碍相关的成本和燃烧。除了解决上述研究目标外，该职业发展奖（CDA）还将提供申请人劳伦·卡塔拉诺（Lauren T. Catalano）博士，并在以下领域进行了培训精神分裂症和社会动机的神经科学；（2）高级脑电图（EEG）技术；（3）通过移动智能手机技术进行数字表型。申请人的职业目标是成为VA- 基于心理学的临床研究人员，致力于改善退伍军人经历的社会残疾严重的精神疾病。此CDA申请中概述的培训将为该申请奠定基础在VA中制定独立研究计划的重点是精神分裂症的社会动机。 VISN 22精神疾病研究，教育和临床中心（MIRECC）医疗保健系统（GLA）和加利福尼亚大学洛杉矶分校（UCLA）提供了出色的完成拟议的研究的环境和基础设施。主要导师将是Michael F. Green，博士，VISN 22 MIRECC治疗部门的主任，VA研究增强奖的主任计划（REAP），以增强无家可归者的社区融合和一位既定的研究人员在精神分裂症领域。申请人还将获得脑电图专家的专业培训患有严重精神疾病的退伍军人的方法论（Jonathan K. Wynn，PhD）和移动领域的领先专家严重精神疾病的退伍军人评估方法（Eric L. Granholm，PhD）。