Approaches to Studying Social Motivation in Schizophrenia

人类是高度社会性的存在，他们有寻找、参与和维持人际关系的动机 与他人的关系。这种基本的人类动力被称为社会动力。然而，退伍军人 精神分裂症患者经常经历社交动机的中断，导致社交功能不佳。 目前的循证治疗在改善社会动机方面还不够有效。 患有精神分裂症的退伍军人。为了通知新的治疗方法的开发，新的实验方法是 这将产生对这个普遍存在的问题的更全面的理解。目前的提案 采用了美国国立卫生研究院(NIMH)研究的社会动机理论框架 领域标准(RDoC)，它将社会动机解析为两个主要组成部分：社会关注和社会 记忆。社会关注指的是优先关注环境的社会方面的偏见，以及 包括注意力捕捉和持续注意力两个阶段。社会记忆指的是记忆的能力 我们与谁互动以建立和维护关系，并涉及记忆编码和 取回。目前尚不清楚退伍军人在什么阶段开始出现社会动机障碍 精神分裂症。此外，这两个社会动机成分对社会的相对贡献 功能尚不清楚。精神分裂症的社会功能传统上是由临床医生评估的- 评级访谈，在理解现实世界社会功能的复杂性方面的专业性有限。 这项建议的总体目标是阐明这两种社会动机的相对贡献 构成要素(社会注意和社会记忆)及其在现实社会中的特定加工阶段 精神分裂症退伍军人的功能。该提案利用了一种创新的多模式方法， 阐明了脑电(EEG)的处理阶段，以及现实世界中的社会功能 通过智能手机技术进行数字表型。这项研究的结果有可能推动我们的 了解精神分裂症患者的社会动机，并确定特定的治疗目标 退伍军人管理局与这种衰弱障碍相关的成本和负担。 除了解决上述研究目标外，该职业发展奖(CDA)还将提供 申请者，Lauren T.Catalano，博士，接受过以下领域的培训：(1)社会领域的翻译研究 精神分裂症和社会动机的神经科学；(2)先进的脑电技术； 以及(3)通过移动智能手机技术进行数字表型。申请者的职业目标是成为一名退伍军人- 基于心理学的临床研究人员，致力于改善退伍军人经历的社会残疾 严重的精神疾病。此CDA申请中概述的培训将为申请者奠定基础 在退伍军人管理局内制定一个独立的研究计划，专注于精神分裂症的社会动机。这个 退伍军人事务部大洛杉矶精神疾病研究、教育和临床中心(MIRECC) 医疗保健系统(GLA)和加州大学洛杉矶分校(UCLA)提供了出色的 环境和基础设施以完成拟议的研究。主要导师将是迈克尔·F·格林， 博士，VISN 22 MIRECC治疗单元主任，退伍军人研究促进奖主任 加强无家可归退伍军人社区融合计划(REAP)，以及一位知名研究人员 在精神分裂症领域。申请者还将接受脑电专家的专门培训 患有严重精神疾病的退伍军人的方法论(乔纳森·K·韦恩博士)，移动领域的领先专家 患有严重精神疾病的退伍军人的评估方法(埃里克·L·格兰霍姆博士)。

Humans are highly social beings that are motivated to seek out, engage in, and maintain interpersonal relationships with others. This fundamental human drive is referred to as social motivation. However, Veterans with schizophrenia often experience disruptions in social motivation, resulting in poor social functioning. Current evidence-based treatments are not sufficiently effective at improving impairments in social motivation in Veterans with schizophrenia. To inform novel treatment development, new experimental approaches are needed that will generate a more complete understanding of this pervasive problem. The current proposal adapts a theoretical framework of social motivation from the National Institutes of Health (NIMH) Research Domain Criteria (RDoC), which parses social motivation into two major components: social attention and social memory. Social attention refers to the bias to preferentially attend to social aspects of the environment, and involves stages of attention capture and sustained attention. Social memory refers to the ability to remember who we interacted with to establish and maintain relationships, and involves stages of memory encoding and retrieval. It is not clear the stage at which social motivation impairments begin to emerge for Veterans with schizophrenia. Additionally, the relative contribution of these two social motivation components on social functioning is not known. Social functioning in schizophrenia has traditionally been assessed using clinician- rated interviews, which has limited specificity in understanding the complexities of real-world social functioning. The overall goal of this proposal is to elucidate the relative contribution of the two social motivation components (social attention and social memory) and their specific stages of processing on real-world social functioning in Veterans with schizophrenia. The proposal utilizes an innovative multi-modal approach that elucidates stages of processing with electroencephalography (EEG), and real-world social functioning with digital phenotyping via smartphone technology. The results of this study have the potential to advance our understanding of social motivation in schizophrenia and to identify specific treatment targets that will reduce the cost and burden associated with this debilitating disorder at the VA. In addition to addressing the above research goals, this Career Development Award (CDA) will provide the applicant, Lauren T. Catalano, PhD, with the training in the areas of: (1) translational research in the social neuroscience of schizophrenia and social motivation; (2) advanced electroencephalography (EEG) techniques; and (3) digital phenotyping via mobile smartphone technology. The applicant’s career goal is to become a VA- based psychology clinician researcher, working to improve the social disability experienced by Veterans with serious mental illness. The training outlined in this CDA application will lay the groundwork for the applicant to develop an independent research program within the VA focused on social motivation in schizophrenia. The VISN 22 Mental Illness Research, Education, and Clinical Center (MIRECC) at the VA Greater Los Angeles Healthcare System (GLA), and the University of California, Los Angeles (UCLA) provides an excellent environment and infrastructure to complete the proposed study. The primary mentor will be Michael F. Green, PhD, the Director of the VISN 22 MIRECC Treatment Unit, Director of the VA Research Enhancement Award Program (REAP) for Enhancing Community Integration in Homeless Veterans, and an established researcher in the field of schizophrenia. The applicant will also receive specialized training from an expert in EEG methodology in Veterans with serious mental illness (Jonathan K. Wynn, PhD), and a leading expert in mobile assessment methodology in Veterans with serious mental illness (Eric L. Granholm, PhD).