Multidisciplinary Investigations in Visual Science

视觉科学的多学科研究

• 批准号: 10663388
• 负责人: Val C. Sheffield
• 金额: $ 61.8万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663388
• 关键词: 3-Dimensional; Acute; Anterior; Bioinformatics; Biometry; Biostatistics Core; COVID-19 pandemic; COVID-19 testing; Center Core Grants; Communication; Communities; Computing Methodologies; Data Set; Electroretinography; Equipment; Experimental Designs; Faculty; Fluorescein Angiography; Funding; Fundus; Gene Expression; Goals; Gonioscopy; Grant; Histologic; Investigation; Iowa; Laboratories; Laboratory Personnel; Light; Methods; Mus; National Eye Institute; Optical Coherence Tomography; Outcome; Phenotype; Photography; Physiologic Intraocular Pressure; Procedures; Productivity; Pupil light reflex; Rattus; Reproducibility; Research; Research Activity; Research Personnel; Research Technics; Resources; Rodent; Roentgen Rays; Services; Standardization; Statistical Methods; Supervision; Technical Expertise; Techniques; Testing; Tissues; Training; Universities; Update; Vision; Vision research; Work; behavior measurement; confocal imaging; cost; database of Genotypes and Phenotypes; experience; experimental analysis; improved; laser capture microdissection; live cell imaging; meetings; member; molecular imaging; multidisciplinary; new technology; open source; programs; reconstruction; response; vision science

PROJECT SUMMARY The goal of this National Eye Institute (NEI) P30 competitive renewal is to continue to enhance the research activities of NEI-funded investigators at The University of Iowa. This will be achieved by providing a suite of Core Services, performed by skilled technical staff and supervised by experienced NEI-funded faculty members, employing standardized, automated procedures when possible. We have modified the Core Services in this renewal application to continue to provide the most up-to-date state-of-the-art services to meet the evolving needs of NEI-funded faculty at The University of Iowa. The combination of centralization (allowing specialization and concomitant increases in efficiency) and the breadth of services available from the various Cores are expected to continue to provide utility and increased productivity to all vision researchers at The University of Iowa. The University of Iowa NEI P30 program is aimed at supporting three primary service cores: 1) Molecular Imaging Core; 2) Rodent Phenotyping Core; and 3) Bioinformatics and Biostatistics Core. The capabilities of and research activities provided by these cores all require specialized equipment and highly trained staff that would be inefficient and costly to duplicate in every laboratory seeking to employ these techniques.

项目摘要 此次国家眼科研究所（NEI）P30竞争性更新的目标是继续增强 爱荷华州大学NEI资助的研究人员的研究活动。这将是 通过提供一套由熟练的技术人员执行的核心服务来实现， 由经验丰富的NEI资助的教师监督，采用标准化，自动化 尽可能的程序。我们已修改此续订申请中的核心服务， 继续提供最先进的服务，以满足不断变化的需求， NEI资助的爱荷华州大学教师。集中化（允许 专业化和随之而来的效率提高）和提供服务的广度 从各种核心预计将继续提供实用程序和提高生产力， 爱荷华州大学的所有视觉研究人员。 爱荷华州大学NEI P30计划旨在支持三个主要服务核心：1） 分子成像核心; 2）啮齿动物表型核心; 3）生物信息学和生物统计学 核心这些核心的能力和提供的研究活动都需要专门的 设备和训练有素的工作人员，这将是效率低下和昂贵的重复，在每一个 实验室正在寻找这些技术。

项目成果

Using Goldmann Visual Field Volume to Track Disease Progression in Choroideremia.

使用 Goldmann 视野体积追踪无脉络膜症的疾病进展。

• DOI: 10.1016/j.xops.2023.100397
• 发表时间: 2023-12
• 期刊: OPHTHALMOLOGY SCIENCE
• 作者: Deluca, Adam P.;Whitmore, S. Scott;Tatro, Nicole J.;Andorf, Jeaneen L.;Faga, Ben P.;Faga, Laurel A.;Colins, Malia M.;Luse, Meagan A.;Fenner, Beau J.;Stone, Edwin M.;Scheetz, Todd E.
• 通讯作者: Scheetz, Todd E.

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma.

• DOI: 10.1167/iovs.16-20672
• 发表时间: 2017-04-01
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Zhu W;Jain A;Gramlich OW;Tucker BA;Sheffield VC;Kuehn MH
• 通讯作者: Kuehn MH

CRISPR-Cas9-Based Genome Editing of Human Induced Pluripotent Stem Cells.

• DOI: 10.1002/cpsc.46
• 发表时间: 2018-02-28
• 期刊: Current protocols in stem cell biology
• 作者: Giacalone, Joseph C;Sharma, Tasneem P;Tucker, Budd A
• 通讯作者: Tucker, Budd A

Long-Term Outcomes and Risk Factors for Severe Vision Loss in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV).

• DOI: 10.1016/j.ajo.2021.07.015
• 发表时间: 2022-01
• 期刊: AMERICAN JOURNAL OF OPHTHALMOLOGY
• 影响因子: 4.2
• 作者: Boyce, Timothy M.;Whitmore, S. Scott;Varzavand, Katayoun;Russell, Stephen R.;Sohn, Elliott H.;Folk, James C.;Stone, Edwin M.;Han, Ian C.
• 通讯作者: Han, Ian C.

Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein.

• DOI: 10.1371/journal.pgen.1006936
• 发表时间: 2017-07
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Scott CA;Marsden AN;Rebagliati MR;Zhang Q;Chamling X;Searby CC;Baye LM;Sheffield VC;Slusarski DC
• 通讯作者: Slusarski DC