Multidisciplinary Investigations in Visual Science
Multidisciplinary Investigations in Visual Science
批准号:
10663388
负责人:
Val C. Sheffield
金额:
$61.8万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
未结题
起止时间:
2016-09-01 至 2026-06-30
关键词:
3-DimensionalAcuteAnteriorBioinformaticsBiometryBiostatistics CoreCOVID-19 pandemicCOVID-19 testingCenter Core GrantsCommunicationCommunitiesComputing MethodologiesData SetElectroretinographyEquipmentExperimental DesignsFacultyFluorescein AngiographyFundingFundusGene ExpressionGoalsGonioscopyGrantHistologicInvestigationIowaLaboratoriesLaboratory PersonnelLightMethodsMusNational Eye InstituteOptical Coherence TomographyOutcomePhenotypePhotographyPhysiologic Intraocular PressureProceduresProductivityPupil light reflexRattusReproducibilityResearchResearch ActivityResearch PersonnelResearch TechnicsResourcesRodentRoentgen RaysServicesStandardizationStatistical MethodsSupervisionTechnical ExpertiseTechniquesTestingTissuesTrainingUniversitiesUpdateVisionVision researchWorkbehavior measurementconfocal imagingcostdatabase of Genotypes and Phenotypesexperienceexperimental analysisimprovedlaser capture microdissectionlive cell imagingmeetingsmembermolecular imagingmultidisciplinarynew technologyopen sourceprogramsreconstructionresponsevision science
中文摘要
项目总结
本次国家眼科研究所(NEI)P30竞争更新的目标是继续增强
爱荷华大学NEI资助的研究人员的研究活动。这将是
通过提供一套核心服务来实现,由熟练的技术人员和
由经验丰富的NEI资助的教职员工监督,使用标准化、自动化
如有可能,请按程序行事。我们已将此续订申请中的核心服务修改为
继续提供最先进的服务,以满足不断发展的
爱荷华大学NEI资助的教职员工。集中化的组合(允许
专业化和随之而来的效率提高)和可用服务的广度
预计将继续从各个核心提供实用程序并提高工作效率,以
爱荷华大学的所有视觉研究人员。
爱荷华大学NEI P30计划旨在支持三个主要服务核心:1)
分子成像核心;2)啮齿动物表型核心;以及3)生物信息学和生物统计学
核心。这些核心的能力和研究活动都需要专门的
设备和训练有素的员工,如果在每个项目中复制,效率低且成本高
寻求使用这些技术的实验室。
英文摘要
PROJECT SUMMARY
The goal of this National Eye Institute (NEI) P30 competitive renewal is to continue to enhance
the research activities of NEI-funded investigators at The University of Iowa. This will be
achieved by providing a suite of Core Services, performed by skilled technical staff and
supervised by experienced NEI-funded faculty members, employing standardized, automated
procedures when possible. We have modified the Core Services in this renewal application to
continue to provide the most up-to-date state-of-the-art services to meet the evolving needs of
NEI-funded faculty at The University of Iowa. The combination of centralization (allowing
specialization and concomitant increases in efficiency) and the breadth of services available
from the various Cores are expected to continue to provide utility and increased productivity to
all vision researchers at The University of Iowa.
The University of Iowa NEI P30 program is aimed at supporting three primary service cores: 1)
Molecular Imaging Core; 2) Rodent Phenotyping Core; and 3) Bioinformatics and Biostatistics
Core. The capabilities of and research activities provided by these cores all require specialized
equipment and highly trained staff that would be inefficient and costly to duplicate in every
laboratory seeking to employ these techniques.
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Using Goldmann Visual Field Volume to Track Disease Progression in Choroideremia.
使用 Goldmann 视野体积追踪无脉络膜症的疾病进展。
DOI:
10.1016/j.xops.2023.100397
发表时间:
2023-12
期刊:
OPHTHALMOLOGY SCIENCE
影响因子:
--
作者:
[Deluca, Adam P., Whitmore, S. Scott, Tatro, Nicole J., Andorf, Jeaneen L., Faga, Ben P., Faga, Laurel A., Colins, Malia M., Luse, Meagan A., Fenner, Beau J., Stone, Edwin M., Scheetz, Todd E.]
通讯作者:
Scheetz, Todd E.
DOI:
10.1167/iovs.16-20672
发表时间:
2017-04-01
期刊:
Investigative ophthalmology & visual science
影响因子:
4.4
作者:
[Zhu W, Jain A, Gramlich OW, Tucker BA, Sheffield VC, Kuehn MH]
通讯作者:
Kuehn MH
Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.
大量和单细胞基因表达分析表明,衰老的人类脉络膜毛细血管具有促炎表型。
DOI:
10.1016/j.mvr.2020.104031
发表时间:
2020
期刊:
Microvascular research
影响因子:
3.1
作者:
[Voigt,AndrewP, Whitmore,SScott, Mulfaul,Kelly, Chirco,KathleenR, Giacalone,JosephC, Flamme-Wiese,MilesJ, Stockman,Adam, Stone,EdwinM, Tucker,BuddA, Scheetz,ToddE, Mullins,RobertF]
通讯作者:
Mullins,RobertF
Choroidal Neovascularization Is Common in Best Vitelliform Macular Dystrophy and Plays a Role in Vitelliform Lesion Evolution.
脉络膜新生血管在最佳卵黄样黄斑营养不良中很常见,并且在卵黄样病变演变中发挥作用。
DOI:
10.1016/j.oret.2022.11.014
发表时间:
2023
期刊:
Ophthalmology. Retina
影响因子:
--
作者:
[Han,IanC, Coussa,RazekGeorges, Mansoor,Mahsaw, Critser,DBrice, Sohn,ElliottH, Russell,JonathanF, Stone,EdwinM]
通讯作者:
Stone,EdwinM
GENE EXPRESSION WITHIN A HUMAN CHOROIDAL NEOVASCULAR MEMBRANE USING SPATIAL TRANSCRIPTOMICS.
使用空间转录组学在人类脉络膜新生血管膜内进行基因表达。
DOI:
10.1101/2023.06.16.544770
发表时间:
2023
期刊:
bioRxiv : the preprint server for biology
影响因子:
--
作者:
[Voigt,AndrewP, Mullin,NathanielK, Navratil,EmmaM, Flamme-Wiese,MilesJ, Lin,Li-Chun, Scheetz,ToddE, Han,IanC, Stone,EdwinM, Tucker,BuddA, Mullins,RobertF]
通讯作者:
Mullins,RobertF
共 57 条
Evaluation of Orthogonally Oriented Electromagnetic Fields to Stabilize ROS, Induce DNA damage and Improve Survival in Non-Small Cell Lung Cancer
-
批准号:10447184
-
项目类别:
-
资助金额:$17.7万
-
财政年份:2021
-
负责人:Val C. Sheffield
-
依托单位:
Evaluation of Orthogonally Oriented Electromagnetic Fields to Stabilize ROS, Induce DNA damage and Improve Survival in Non-Small Cell Lung Cancer
-
批准号:10290446
-
项目类别:
-
资助金额:$21.67万
-
财政年份:2021
-
负责人:Val C. Sheffield
-
依托单位:
Multidisciplinary Investigations in Visual Science
-
批准号:10271728
-
项目类别:
-
资助金额:$61.8万
-
财政年份:2016
-
负责人:Val C. Sheffield
-
依托单位:
Administrative Core
-
批准号:10271729
-
项目类别:
-
资助金额:$9.19万
-
财政年份:2016
-
负责人:Val C. Sheffield
-
依托单位:
Multidisciplinary Investigations in Visual Science
-
批准号:9762933
-
项目类别:
-
资助金额:$52.1万
-
财政年份:2016
-
负责人:Val C. Sheffield
-
依托单位:
Administrative Core
-
批准号:10488229
-
项目类别:
-
资助金额:$9.19万
-
财政年份:2016
-
负责人:Val C. Sheffield
-
依托单位:
Multidisciplinary Investigations in Visual Science
-
批准号:10488228
-
项目类别:
-
资助金额:$61.8万
-
财政年份:2016
-
负责人:Val C. Sheffield
-
依托单位:
Administrative Core
-
批准号:10663389
-
项目类别:
-
资助金额:$9.19万
-
财政年份:2016
-
负责人:Val C. Sheffield
-
依托单位:
Multidisciplinary Investigations in Visual Science
-
批准号:9334864
-
项目类别:
-
资助金额:$52.86万
-
财政年份:2016
-
负责人:Val C. Sheffield
-
依托单位:
Role of Neural Progenitor Cells in the Development of Neonatal Hydrocephalus
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批准号:8657125
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项目类别:
-
资助金额:$32.7万
-
财政年份:2013
-
负责人:Val C. Sheffield
-
依托单位:
Role of Neural Progenitor Cells in the Development of Neonatal Hydrocephalus
-
批准号:8555709
-
项目类别:
-
资助金额:$33.03万
-
财政年份:2013
-
负责人:Val C. Sheffield
-
依托单位:
Interdisciplinary approach to retinal disease gene identification
-
批准号:7264071
-
项目类别:
-
资助金额:$37.45万
-
财政年份:2007
-
负责人:Val C. Sheffield
-
依托单位:
Interdisciplinary approach to retinal disease gene identification
-
批准号:7493821
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项目类别:
-
资助金额:$15.18万
-
财政年份:2007
-
负责人:Val C. Sheffield
-
依托单位:
Interdisciplinary approach to retinal disease gene identification
-
批准号:8082667
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项目类别:
-
资助金额:$56.37万
-
财政年份:2007
-
负责人:Val C. Sheffield
-
依托单位:
Interdisciplinary approach to retinal disease gene identification
-
批准号:7903589
-
项目类别:
-
资助金额:$66.72万
-
财政年份:2007
-
负责人:Val C. Sheffield
-
依托单位:
Complex Mechanisms in Bardet-Biedl Syndrome Retinopathy
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批准号:8436095
-
项目类别:
-
资助金额:$49.04万
-
财政年份:2007
-
负责人:Val C. Sheffield
-
依托单位:
Interdisciplinary approach to retinal disease gene identification
-
批准号:7860547
-
项目类别:
-
资助金额:$57.01万
-
财政年份:2007
-
负责人:Val C. Sheffield
-
依托单位:
Interdisciplinary approach to retinal disease gene identification
-
批准号:7429652
-
项目类别:
-
资助金额:$53.19万
-
财政年份:2007
-
负责人:Val C. Sheffield
-
依托单位:
Complex Mechanisms in Bardet-Biedl Syndrome Retinopathy
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批准号:8986788
-
项目类别:
-
资助金额:$49.04万
-
财政年份:2007
-
负责人:Val C. Sheffield
-
依托单位:
Complex Mechanisms in Bardet-Biedl Syndrome Retinopathy
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批准号:8595310
-
项目类别:
-
资助金额:$48.06万
-
财政年份:2007
-
负责人:Val C. Sheffield
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依托单位:
海外基金