Multidisciplinary Investigations in Visual Science
视觉科学的多学科研究
基本信息
- 批准号:10663388
- 负责人:
- 金额:$ 61.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAcuteAnteriorBioinformaticsBiometryBiostatistics CoreCOVID-19 pandemicCOVID-19 testingCenter Core GrantsCommunicationCommunitiesComputing MethodologiesData SetElectroretinographyEquipmentExperimental DesignsFacultyFluorescein AngiographyFundingFundusGene ExpressionGoalsGonioscopyGrantHistologicInvestigationIowaLaboratoriesLaboratory PersonnelLightMethodsMusNational Eye InstituteOptical Coherence TomographyOutcomePhenotypePhotographyPhysiologic Intraocular PressureProceduresProductivityPupil light reflexRattusReproducibilityResearchResearch ActivityResearch PersonnelResearch TechnicsResourcesRodentRoentgen RaysServicesStandardizationStatistical MethodsSupervisionTechnical ExpertiseTechniquesTestingTissuesTrainingUniversitiesUpdateVisionVision researchWorkbehavior measurementconfocal imagingcostdatabase of Genotypes and Phenotypesexperienceexperimental analysisimprovedlaser capture microdissectionlive cell imagingmeetingsmembermolecular imagingmultidisciplinarynew technologyopen sourceprogramsreconstructionresponsevision science
项目摘要
PROJECT SUMMARY
The goal of this National Eye Institute (NEI) P30 competitive renewal is to continue to enhance
the research activities of NEI-funded investigators at The University of Iowa. This will be
achieved by providing a suite of Core Services, performed by skilled technical staff and
supervised by experienced NEI-funded faculty members, employing standardized, automated
procedures when possible. We have modified the Core Services in this renewal application to
continue to provide the most up-to-date state-of-the-art services to meet the evolving needs of
NEI-funded faculty at The University of Iowa. The combination of centralization (allowing
specialization and concomitant increases in efficiency) and the breadth of services available
from the various Cores are expected to continue to provide utility and increased productivity to
all vision researchers at The University of Iowa.
The University of Iowa NEI P30 program is aimed at supporting three primary service cores: 1)
Molecular Imaging Core; 2) Rodent Phenotyping Core; and 3) Bioinformatics and Biostatistics
Core. The capabilities of and research activities provided by these cores all require specialized
equipment and highly trained staff that would be inefficient and costly to duplicate in every
laboratory seeking to employ these techniques.
项目摘要
此次国家眼科研究所(NEI)P30竞争性更新的目标是继续增强
爱荷华州大学NEI资助的研究人员的研究活动。这将是
通过提供一套由熟练的技术人员执行的核心服务来实现,
由经验丰富的NEI资助的教师监督,采用标准化,自动化
尽可能的程序。我们已修改此续订申请中的核心服务,
继续提供最先进的服务,以满足不断变化的需求,
NEI资助的爱荷华州大学教师。集中化(允许
专业化和随之而来的效率提高)和提供服务的广度
从各种核心预计将继续提供实用程序和提高生产力,
爱荷华州大学的所有视觉研究人员。
爱荷华州大学NEI P30计划旨在支持三个主要服务核心:1)
分子成像核心; 2)啮齿动物表型核心; 3)生物信息学和生物统计学
核心这些核心的能力和提供的研究活动都需要专门的
设备和训练有素的工作人员,这将是效率低下和昂贵的重复,在每一个
实验室正在寻找这些技术。
项目成果
期刊论文数量(111)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Using Goldmann Visual Field Volume to Track Disease Progression in Choroideremia.
使用 Goldmann 视野体积追踪无脉络膜症的疾病进展。
- DOI:10.1016/j.xops.2023.100397
- 发表时间:2023-12
- 期刊:
- 影响因子:0
- 作者:Deluca, Adam P.;Whitmore, S. Scott;Tatro, Nicole J.;Andorf, Jeaneen L.;Faga, Ben P.;Faga, Laurel A.;Colins, Malia M.;Luse, Meagan A.;Fenner, Beau J.;Stone, Edwin M.;Scheetz, Todd E.
- 通讯作者:Scheetz, Todd E.
Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma.
- DOI:10.1167/iovs.16-20672
- 发表时间:2017-04-01
- 期刊:
- 影响因子:4.4
- 作者:Zhu W;Jain A;Gramlich OW;Tucker BA;Sheffield VC;Kuehn MH
- 通讯作者:Kuehn MH
Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.
大量和单细胞基因表达分析表明,衰老的人类脉络膜毛细血管具有促炎表型。
- DOI:10.1016/j.mvr.2020.104031
- 发表时间:2020
- 期刊:
- 影响因子:3.1
- 作者:Voigt,AndrewP;Whitmore,SScott;Mulfaul,Kelly;Chirco,KathleenR;Giacalone,JosephC;Flamme-Wiese,MilesJ;Stockman,Adam;Stone,EdwinM;Tucker,BuddA;Scheetz,ToddE;Mullins,RobertF
- 通讯作者:Mullins,RobertF
Choroidal Neovascularization Is Common in Best Vitelliform Macular Dystrophy and Plays a Role in Vitelliform Lesion Evolution.
脉络膜新生血管在最佳卵黄样黄斑营养不良中很常见,并且在卵黄样病变演变中发挥作用。
- DOI:10.1016/j.oret.2022.11.014
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Han,IanC;Coussa,RazekGeorges;Mansoor,Mahsaw;Critser,DBrice;Sohn,ElliottH;Russell,JonathanF;Stone,EdwinM
- 通讯作者:Stone,EdwinM
GENE EXPRESSION WITHIN A HUMAN CHOROIDAL NEOVASCULAR MEMBRANE USING SPATIAL TRANSCRIPTOMICS.
使用空间转录组学在人类脉络膜新生血管膜内进行基因表达。
- DOI:10.1101/2023.06.16.544770
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Voigt,AndrewP;Mullin,NathanielK;Navratil,EmmaM;Flamme-Wiese,MilesJ;Lin,Li-Chun;Scheetz,ToddE;Han,IanC;Stone,EdwinM;Tucker,BuddA;Mullins,RobertF
- 通讯作者:Mullins,RobertF
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Val C. Sheffield其他文献
Three autosomal dominant corneal dystrophies map to chromosome 5q
三种常染色体显性遗传性角膜营养不良定位于 5q 染色体
- DOI:
10.1038/ng0194-47 - 发表时间:
1994-01-01 - 期刊:
- 影响因子:29.000
- 作者:
Edwin M. Stone;William D. Mathers;George O.D. Rosenwasser;Edward J. Holland;Robert Folberg;Jay H. Krachmer;Brian E. Nichols;Peter D. Gorevic;Chris M. Taylor;Luan M. Streb;Jill A. Fishbaugh;Thomas E. Daley;Brian M. Sucheski;Val C. Sheffield - 通讯作者:
Val C. Sheffield
De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis
与莱伯先天性黑蒙症相关的 CRX 同源框基因的从头突变
- DOI:
10.1038/ng0498-311 - 发表时间:
1998-04-01 - 期刊:
- 影响因子:29.000
- 作者:
Carol L. Freund;Qing-Ling Wang;Shiming Chen;Brenda L. Muskat;Carmella D. Wiles;Val C. Sheffield;Samuel G. Jacobson;Roderick R. Mclnnes;Donald J. Zack;Edwin M. Stone - 通讯作者:
Edwin M. Stone
Gene therapy and gene correction: targets, progress, and challenges for treating human diseases
基因治疗和基因校正:治疗人类疾病的靶点、进展和挑战
- DOI:
10.1038/s41434-020-00197-8 - 发表时间:
2020-10-09 - 期刊:
- 影响因子:4.500
- 作者:
Matthew R. Cring;Val C. Sheffield - 通讯作者:
Val C. Sheffield
Identification of the gene that, when mutated, causes the human obesity syndrome BBS4
对导致人类肥胖综合征 BBS4 的基因突变基因的鉴定
- DOI:
10.1038/88925 - 发表时间:
2001-06-01 - 期刊:
- 影响因子:29.000
- 作者:
Kirk Mykytyn;Terry Braun;Rivka Carmi;Neena B. Haider;Charles C. Searby;Mythreyi Shastri;Gretel Beck;Alan F. Wright;Alessandro Iannaccone;Khalil Elbedour;Ruth Riise;Alfonso Baldi;Annick Raas-Rothschild;Susan W. Gorman;David M. Duhl;Samuel G. Jacobson;Thomas Casavant;Edwin M. Stone;Val C. Sheffield - 通讯作者:
Val C. Sheffield
A denaturing gradient gel electrophoresis assay for sensitive detection of p53 mutations
- DOI:
10.1007/bf00230217 - 发表时间:
1993-03-01 - 期刊:
- 影响因子:3.600
- 作者:
John S. Beck;Anne E. Kwitek;Phillip H. Cogen;Andrew K. Metzger;Geoffrey M. Duyk;Val C. Sheffield - 通讯作者:
Val C. Sheffield
Val C. Sheffield的其他文献
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{{ truncateString('Val C. Sheffield', 18)}}的其他基金
Evaluation of Orthogonally Oriented Electromagnetic Fields to Stabilize ROS, Induce DNA damage and Improve Survival in Non-Small Cell Lung Cancer
正交定向电磁场稳定 ROS、诱导 DNA 损伤和提高非小细胞肺癌生存率的评估
- 批准号:
10447184 - 财政年份:2021
- 资助金额:
$ 61.8万 - 项目类别:
Evaluation of Orthogonally Oriented Electromagnetic Fields to Stabilize ROS, Induce DNA damage and Improve Survival in Non-Small Cell Lung Cancer
正交定向电磁场稳定 ROS、诱导 DNA 损伤和提高非小细胞肺癌生存率的评估
- 批准号:
10290446 - 财政年份:2021
- 资助金额:
$ 61.8万 - 项目类别:
Multidisciplinary Investigations in Visual Science
视觉科学的多学科研究
- 批准号:
10271728 - 财政年份:2016
- 资助金额:
$ 61.8万 - 项目类别:
Multidisciplinary Investigations in Visual Science
视觉科学的多学科研究
- 批准号:
10488228 - 财政年份:2016
- 资助金额:
$ 61.8万 - 项目类别:
Role of Neural Progenitor Cells in the Development of Neonatal Hydrocephalus
神经祖细胞在新生儿脑积水发展中的作用
- 批准号:
8657125 - 财政年份:2013
- 资助金额:
$ 61.8万 - 项目类别:
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