Summer Undergraduate Program to Educate Radiation Scientists (SUPERS)

辐射科学家教育暑期本科生计划（SUPERS）

• 批准号: 10663158
• 负责人: JAY FITZGERALD DORSEY
• 金额: $ 21.19万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-08 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663158
• 关键词: Bioethics; Biomedical Research; CCL7 gene; Cancer Biology; Cancer Center; Career Choice; Chalk; Collaborations; Critical Thinking; Data; Discipline; Education; Educational process of instructing; Electronic Mail; Equipment; Evaluation; Faculty; Female; Foundations; Functional disorder; Funding; Gender; Goals; Graduate Degree; Grant; Hour; Image; Institution; International; Interview; Journals; Laboratories; Laboratory Research; Malignant Neoplasms; Measures; Mentors; Methodology; Methods; Minority; Minority Enrollment; Modality; Online Systems; Oral; Participant; Patient Recruitments; Pennsylvania; Physics; Postbaccalaureate; Process; Productivity; Public Speaking; Radiation; Radiation Oncology; Radiation Physics; Radiation therapy; Radiobiology; Radiology Specialty; Recruitment Activity; Research; Research Personnel; Research Project Grants; School Enrollments; Schools; Science; Scientist; Series; Social Network; Student recruitment; Students; Study Section; Surveys; Talents; Training; Training Programs; Underrepresented Populations; Underrepresented Students; United States; United States National Institutes of Health; Universities; Visit; academic program; anticancer research; cancer imaging; cancer therapy; career; college; experience; field study; graduate school; improved; interest; learning strategy; lectures; medical schools; next generation; ovid; programs; recruit; social media; socioeconomic disadvantage; student retention; success; summer research; supportive environment; undergraduate student; web site

PROJECT SUMMARY/ABSTRACT Despite the fact that radiation therapy is one of the three primary modalities used in the treatment of cancer, the active number of researchers in the fields of radiation biology or physics has been in decline over the past three decades. The Summer Undergraduate Program to Educate Radiation Scientists at the University of Pennsylvania (SUPERS@PENN) was proposed as a means to begin to reverse this recognized crisis. We hypothesize that by providing undergraduate students with a supportive environment that teaches them the underpinnings of cancer and radiation biology, physics and imaging, early in their college careers, that we will encourage a significant number of these students to ultimately pursue cancer and radiation research as a career path. A key thrust of our training program is to identify and recruit participants from various underrepresented populations, thereby promoting greater diversity among radiation scientists. Initially submitted in 2009, the program obtained strong support from study section (score 11, 1.0 percentile) received NIH funding in 2010 and was successful in competitive renewal in 2015. We have continued to successfully meet the proposed aims of the program, with a large percentage of our alumni (including minority, socioeconomically underprivileged and female gender) having now moved on to graduate programs, with a continued focus on an eventual career in cancer and radiation research. Our goal for this competitive renewal is to continue to build upon these robust successes. Individualized research projects tailored to each student's interests and experience remain as the core component of the SUPERS program. In addition, didactic lectures from faculty experts in the fields of cancer biology, radiation biology, radiation physics and cancer imaging provide a foundation for students. Four hours of bioethics training are incorporated into the didactic lecture series, as per NIH requirements. We continue with the programmatic assessment and evaluative component. Working with colleagues in the Office of Evaluation and Assessment in the Academic Programs at the Perelman School of Medicine, SUPERS has developed methodologies to measure the immediate and long term impact of the program on student participants as they transition from undergraduate to post-baccalaureate studies and eventually into the early part of their research careers. In summary, by completing the specific aims underlying this proposal, we anticipate that we will continue to have a positive impact on quantity, quality and diversity of the next generation of scientists engaged in cancer and radiation related research.

项目摘要/摘要 尽管放射治疗是治疗癌症的三种主要方法之一 癌症，活跃在辐射生物学或物理学领域的研究人员一直在 在过去的三十年里有所下降。暑期本科辐射教育计划 宾夕法尼亚大学的科学家(Supers@Penn)被提议作为一种开始 扭转这场公认的危机。我们假设，通过为本科生提供 支持性环境，向他们传授癌症和辐射生物学、物理学的基础 想象一下，在他们大学生涯的早期，我们将鼓励相当多的这样的人 学生最终将从事癌症和辐射研究作为一条职业道路。我们的一个主要推动力是 培训计划是从不同代表性不足的人群中确定和招募参与者， 从而促进辐射科学家之间的更大多样性。最初于2009年提交， 该计划得到了研究部的大力支持(分数11，百分位数1.0)，在#年获得了NIH的资助 2010年，并在2015年成功地进行了竞争更新。我们继续成功地满足了 该计划的拟议目标，我们的大部分校友(包括少数族裔、 社会经济上的弱势群体和女性)现在进入了研究生课程， 继续专注于癌症和辐射研究的最终职业生涯。我们的目标是 竞争性更新将继续建立在这些强劲成功的基础上。个性化研究 为每个学生的兴趣和经验量身定做的项目仍然是 超级程序。此外，来自癌症生物学领域的教员专家的说教讲座， 辐射生物学、辐射物理学和癌症成像为学生提供了基础。四个小时 根据美国国立卫生研究院的要求，生物伦理培训的内容被纳入到教学系列讲座中。我们 继续进行方案评估和评价部分。与同事一起在 佩雷尔曼学院学术项目评估和评估办公室 医学，Supers已经开发出方法来衡量 该计划针对从本科生过渡到后学士学位的学生参与者 学习，并最终进入他们研究生涯的早期阶段。总而言之，通过完成 作为这项提议背后的具体目标，我们预计我们将继续对 从事癌症和辐射研究的下一代科学家的数量、质量和多样性 相关研究。

项目成果

Monte Carlo modeling in CT-based geometries: dosimetry for biological modeling experiments with particle beam radiation.

基于 CT 的几何形状中的蒙特卡罗建模：粒子束辐射生物建模实验的剂量测定。

• DOI: 10.1093/jrr/rrt118
• 发表时间: 2014
• 期刊: Journal of radiation research
• 影响因子: 2
• 作者: Diffenderfer,EricS;Dolney,Derek;Schaettler,Maximilian;Sanzari,JenineK;McDonough,James;Cengel,KeithA
• 通讯作者: Cengel,KeithA

Mechanisms of blood flow and hypoxia production in rat 9L-epigastric tumors.

• DOI: 10.2478/tumor-2012-0001
• 发表时间: 2013-01
• 期刊: Tumor microenvironment and therapy
• 作者: Koch CJ;Jenkins WT;Jenkins KW;Yang XY;Shuman AL;Pickup S;Riehl CR;Paudyal R;Poptani H;Evans SM
• 通讯作者: Evans SM

The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer.

• DOI: 10.1016/j.bbrc.2015.09.157
• 发表时间: 2015-11-27
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Makvandi M;Tilahun ED;Lieberman BP;Anderson RC;Zeng C;Xu K;Hou C;McDonald ES;Pryma DA;Mach RH
• 通讯作者: Mach RH

Endothelial targeting of polymeric nanoparticles stably labeled with the PET imaging radioisotope iodine-124.

用 PET 成像放射性同位素碘 124 稳定标记的聚合物纳米颗粒的内皮靶向。

• DOI: 10.1016/j.biomaterials.2012.04.036
• 发表时间: 2012-07
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Simone, Eric A.;Zern, Blaine J.;Chacko, Ann-Marie;Mikitsh, John L.;Blankemeyer, Eric R.;Muro, Silvia;Stan, Radu V.;Muzykantov, Vladimir R.
• 通讯作者: Muzykantov, Vladimir R.

Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy.

• DOI: 10.1158/2767-9764.crc-22-0494
• 发表时间: 2023-09
• 期刊: Cancer research communications