Glycemic reduction approaches in polycystic ovary syndrome: a comparative effectiveness study

多囊卵巢综合征的降血糖方法:比较有效性研究

基本信息

  • 批准号:
    10540706
  • 负责人:
  • 金额:
    $ 61.33万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-12-15 至 2026-11-30
  • 项目状态:
    未结题

项目摘要

ABSTRACT Polycystic ovary syndrome (PCOS) is the most common endocrine disorder for women of reproductive age. Women with PCOS are at a high risk of health complications. In fact, women with PCOS have a 3-7 times higher risk for type 2 diabetes, and obese women with PCOS have an even higher risk of type 2 diabetes. Experts recommend that the first-line treatment for overweight and obese women with PCOS should be diet and lifestyle interventions. Yet, experts disagree about the specific nutritional advice these interventions should encourage, with different groups recommending no particular diet, a high-carbohydrate Dietary Approaches to Stop Hypertension (DASH) diet, or a lower carbohydrate diet. A systematic review of previous dietary trials in PCOS did find a slight benefit of lower carbohydrate diets for glucose control, weight loss, insulin, and insulin resistance. This may be because carbohydrate intake raises glucose levels, which in turn increases insulin secretion. Insulin then stimulates ovarian androgen production and inhibits the release of fatty acids from cells. Previous research in type 2 diabetes suggests that not simply lower carbohydrate intake, but a very low- carbohydrate (VLC) diet, with less than 20% of calories from carbohydrates, designed to reduce body weight and glucose levels more significantly than other types of lower carbohydrate diets, would be even more effective for improving metabolic health in PCOS. Although reviews note that a VLC diet has shown promise for type 2 diabetes, prediabetes, obesity, and cardiovascular risk, evidence for PCOS is only emerging. In our recently completed 4-month trial of 29 overweight or obese women with PCOS following a VLC diet, we found significant improvements in outcomes, including glycated hemoglobin (HbA1c; -0.21%) and body weight (-7.7%). We propose a 12-month randomized, controlled trial for 184 overweight or obese (BMI of 28-55 kg/m2) adults with PCOS comparing a VLC diet and a standard-of-care low-fat, Dietary Approaches to Stop Hypertension (DASH) diet. The program for both groups is delivered online, as in our pilot study. Aim 1: To compare changes in glycemic control. We hypothesize that the VLC version will lead to greater improvements in HbA1c at 12-months. Aim 2: To compare changes in secondary health outcomes tied to type 2 diabetes risk, including glycemic variability, conversion to normoglycemia, body weight, and body fat percentage. We hypothesize that the VLC version will lead to greater improvements in secondary health outcomes at 12- months. Aim 3: To explore intervention satisfaction and acceptability. The guiding objective of this proposal is to explore a novel diet and lifestyle approach for reducing the future risk of type 2 diabetes for overweight or obese women with PCOS. We anticipate that the proposed research will have an important impact on diet and lifestyle recommendations for this high-risk, understudied population.
摘要

项目成果

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Laura Saslow其他文献

Laura Saslow的其他文献

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{{ truncateString('Laura Saslow', 18)}}的其他基金

A small steps, low-literacy, breakfast-focused dietary self-management intervention for adults with poorly controlled type 2 diabetes
针对控制不佳的 2 型糖尿病成人的小步骤、低识字率、以早餐为重点的饮食自我管理干预
  • 批准号:
    10417553
  • 财政年份:
    2023
  • 资助金额:
    $ 61.33万
  • 项目类别:
Testing a very low-carbohydrate diet version of the Diabetes Prevention Program to reduce risk factors for type 2 diabetes
测试极低碳水化合物饮食版本的糖尿病预防计划,以减少 2 型糖尿病的危险因素
  • 批准号:
    10468043
  • 财政年份:
    2021
  • 资助金额:
    $ 61.33万
  • 项目类别:
Testing a very low-carbohydrate diet version of the Diabetes Prevention Program to reduce risk factors for type 2 diabetes
测试极低碳水化合物饮食版本的糖尿病预防计划,以减少 2 型糖尿病的危险因素
  • 批准号:
    10206909
  • 财政年份:
    2021
  • 资助金额:
    $ 61.33万
  • 项目类别:
Comparing Two Dietary Approaches for Type 2 Diabetes
比较 2 型糖尿病的两种饮食方法
  • 批准号:
    10297487
  • 财政年份:
    2021
  • 资助金额:
    $ 61.33万
  • 项目类别:
Glycemic reduction approaches in polycystic ovary syndrome: a comparative effectiveness study
多囊卵巢综合征的降血糖方法:比较有效性研究
  • 批准号:
    10363371
  • 财政年份:
    2021
  • 资助金额:
    $ 61.33万
  • 项目类别:
Testing a very low-carbohydrate diet version of the Diabetes Prevention Program to reduce risk factors for type 2 diabetes
测试极低碳水化合物饮食版本的糖尿病预防计划,以减少 2 型糖尿病的危险因素
  • 批准号:
    10602503
  • 财政年份:
    2021
  • 资助金额:
    $ 61.33万
  • 项目类别:
Comparing Two Dietary Approaches for Type 2 Diabetes
比较 2 型糖尿病的两种饮食方法
  • 批准号:
    10437898
  • 财政年份:
    2021
  • 资助金额:
    $ 61.33万
  • 项目类别:
Comparing Two Dietary Approaches for Type 2 Diabetes
比较 2 型糖尿病的两种饮食方法
  • 批准号:
    10621922
  • 财政年份:
    2021
  • 资助金额:
    $ 61.33万
  • 项目类别:
The WELL Study (Wellness Education for Liver Health Study): Reducing liver disease in genetically predisposed adults
WELL 研究(肝脏健康健康教育研究):减少有遗传倾向的成年人的肝病
  • 批准号:
    10112901
  • 财政年份:
    2020
  • 资助金额:
    $ 61.33万
  • 项目类别:

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    2022
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