Clinical Center for NIH's Nutrition for Precision Health: The All Of Us New England Research Collaborative

项目摘要 我们所有的新英格兰临床中心（AoU-NE-CC）是一个合作的新英格兰为基础的研究 在营养和临床转化科学方面拥有必要专业知识和资源的团队， 成功完成NIH共同基金精准健康营养（NPH）临床中心的所有3个模块 程序.塔夫茨大学（Tufts University）的让·迈耶（Jean Mayer）美国农业部人类营养衰老研究中心（Tufts- HNRCA）和马萨诸塞州总医院（MGH）将领导AoU-NE-CC，并与All of Us New合作 英格兰确保参与者的多样性和确定个体间差异所需的科学严谨性 对饮食模式的反应。AoU-NE-CC致力于我们所有人的核心价值观，并已实施 团队科学的最佳实践贯穿其发展始终。AoU-NE-CC将作为 制定严格的NPH共同协议，并检查习惯性饮食摄入量（模块1），测量 对混合餐挑战的生理反应（模块1-3），并确定对3种干预的反应 在自由生活（模块2）和圈养（模块3）控制饲养条件下的饮食。加上 标准的All of Us数据，通过这些模块收集的生理反应将用于开发 预测算法，为长期健康提供精确的营养方法。达到最大 代谢和微生物组反应的可变性，我们提出了以下模块2的14天等热量饮食 和3，间隔4周洗脱期：（1）高坚持饮食方法停止高血压 DASH饮食;（2）低依从性DASH饮食;和（3）生酮饮食。我们还建议使用 经过彻底测试的混合餐挑战PhenFlex，可以在临床中心标准化， 提供代谢灵活性的多系统评估。凭借其卓越的核心设施，包括 代谢厨房和封闭的喂养和护理中心，以及丰富的遗产，进行严格的 喂养研究，AoU-NE-CC是唯一熟练的，并定位为NPH的临床中心。 AoU-NE-CC的其他优势包括招募临床人群的丰富经验， 生物库，通过社区外展吸引志愿者，积极参与全球精准营养 倡议，以及在营养，组学和 精准健康重要的是，Tufts-HNRCA和MGH团队与All of Us New保持密切联系 英格兰队及其高参与者招募和保留的记录及其多样化的队列，这将 支持NPH联盟的目标。通过与NPH和All of Us合作， 科学研究，AoU-NE-CC及其经验丰富，前瞻性思维，高度协作的团队将做出贡献 发展精确的营养方法，以支持整个成年期的最佳健康。

PROJECT SUMMARY The All of Us New England Clinical Center (AoU-NE-CC) is a collaboration of New England–based research teams with the necessary expertise and resources in nutrition and clinical translational science to implement successfully all 3 modules of the NIH Common Fund’s Nutrition for Precision Health (NPH) Clinical Center program. The Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (Tufts- HNRCA) and Massachusetts General Hospital (MGH) will lead the AoU-NE-CC and partner with All of Us New England to ensure the diversity of participants and scientific rigor required to identify inter-individual variability of response to dietary patterns. The AoU-NE-CC is committed to All of Us core values and has implemented best practices of team science throughout its development. The AoU-NE-CC will serve as a key partner in the development of a rigorous NPH common protocol and examine habitual dietary intake (Module 1), measure physiological responses to a mixed-meal challenge (Modules 1-3), and identify responses to 3 intervention diets in both free-living (Module 2) and domiciled (Module 3) controlled feeding conditions. Coupled with standard All of Us data, the physiological responses collected through these modules will be used to develop predictive algorithms that inform precision nutrition approaches for long-term health. To attain maximum metabolic and microbiome response variability, we propose the following 14-day isocaloric diets for Modules 2 and 3, separated by 4-week washout periods: (1) a high-adherence Dietary Approaches to Stop Hypertension (DASH) diet; (2) a low-adherence DASH diet; and (3) a ketogenic diet. We also propose the use of the thoroughly tested mixed-meal challenge PhenFlex, which can be standardized across clinical centers to provide a multisystem assessment of metabolic flexibility. With its outstanding core facilities, including metabolic kitchens and domiciled feeding and nursing centers, as well as a rich legacy of conducting rigorous feeding studies, the AoU-NE-CC is uniquely skilled and positioned to serve as a clinical center for the NPH. Additional strengths of the AoU-NE-CC include extensive experience in recruiting clinical populations and biobanking, engaging volunteers through community outreach, active participation in global precision nutrition initiatives, and an outstanding track record of productive multisite collaborations in nutrition, omics, and precision health. Importantly, the Tufts-HNRCA and MGH teams are closely aligned with the All of Us New England team and its record of high participant recruitment and retention and its diverse cohort, which will support the NPH consortium goals. By partnering with NPH and All of Us in this novel modular discovery science study, the AoU-NE-CC and its experienced, forward-thinking, highly collaborative team will contribute to the development of precision nutrition approaches that support optimal health across the adult lifespan.