Clinical Center for NIH's Nutrition for Precision Health: The All Of Us New England Research Collaborative

美国国立卫生研究院精准健康营养临床中心：我们所有人新英格兰研究合作组织

• 批准号: 10539337
• 负责人: Sai Krupa Das
• 金额: $ 189.89万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-10 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10539337
• 关键词: Address; Adherence; Adult; Adverse event; Aging; Algorithms; All of Us Research Program; Behavioral; Chronic Disease; Clinical; Cognitive; Collaborations; Community Outreach; Community Participation; Core Facility; Coupled; Cross-Over Studies; DASH diet; Data; Development; Diet; Dietary Formulations; Dietary Intervention; Dietary Practices; Dietary intake; Discipline of Nursing; Domiciles; Enrollment; Ensure; Environmental Risk Factor; Food; Formulation; Funding; General Hospitals; Genomics; Goals; Health; Human; Individual; Individual Differences; Inpatients; Longevity; Massachusetts; Measures; Metabolic; Metagenomics; Methods; Modeling; Movement; New England; Non-Insulin-Dependent Diabetes Mellitus; Nutritional Study; Oral; Outcome; Outcome Assessment; Participant; Patient Recruitments; Phase; Physiological; Population; Positioning Attribute; Precision Health; Productivity; Protocols documentation; Public Health; Randomized; Recommendation; Records; Research; Resources; Risk Reduction; Science; Site; Standardization; Surveys; System; Testing; Thinking; Translational Research; United States Department of Agriculture; United States National Institutes of Health; Universities; Variant; Visit; algorithm development; biobank; clinical center; clinical research site; clinical translation; cohort; contextual factors; dietary; dietary adherence; dietary control; doubly-labeled water; eHealth; experience; feeding; flexibility; individual response; individual variation; inter-individual variation; ketogenic diet; metabolomics; microbiome; new technology; non-compliance; novel; nutrition; participant retention; personalized approach; population based; precision nutrition; prediction algorithm; programs; recruit; response; skills; tool; volunteer

PROJECT SUMMARY The All of Us New England Clinical Center (AoU-NE-CC) is a collaboration of New England–based research teams with the necessary expertise and resources in nutrition and clinical translational science to implement successfully all 3 modules of the NIH Common Fund’s Nutrition for Precision Health (NPH) Clinical Center program. The Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (Tufts- HNRCA) and Massachusetts General Hospital (MGH) will lead the AoU-NE-CC and partner with All of Us New England to ensure the diversity of participants and scientific rigor required to identify inter-individual variability of response to dietary patterns. The AoU-NE-CC is committed to All of Us core values and has implemented best practices of team science throughout its development. The AoU-NE-CC will serve as a key partner in the development of a rigorous NPH common protocol and examine habitual dietary intake (Module 1), measure physiological responses to a mixed-meal challenge (Modules 1-3), and identify responses to 3 intervention diets in both free-living (Module 2) and domiciled (Module 3) controlled feeding conditions. Coupled with standard All of Us data, the physiological responses collected through these modules will be used to develop predictive algorithms that inform precision nutrition approaches for long-term health. To attain maximum metabolic and microbiome response variability, we propose the following 14-day isocaloric diets for Modules 2 and 3, separated by 4-week washout periods: (1) a high-adherence Dietary Approaches to Stop Hypertension (DASH) diet; (2) a low-adherence DASH diet; and (3) a ketogenic diet. We also propose the use of the thoroughly tested mixed-meal challenge PhenFlex, which can be standardized across clinical centers to provide a multisystem assessment of metabolic flexibility. With its outstanding core facilities, including metabolic kitchens and domiciled feeding and nursing centers, as well as a rich legacy of conducting rigorous feeding studies, the AoU-NE-CC is uniquely skilled and positioned to serve as a clinical center for the NPH. Additional strengths of the AoU-NE-CC include extensive experience in recruiting clinical populations and biobanking, engaging volunteers through community outreach, active participation in global precision nutrition initiatives, and an outstanding track record of productive multisite collaborations in nutrition, omics, and precision health. Importantly, the Tufts-HNRCA and MGH teams are closely aligned with the All of Us New England team and its record of high participant recruitment and retention and its diverse cohort, which will support the NPH consortium goals. By partnering with NPH and All of Us in this novel modular discovery science study, the AoU-NE-CC and its experienced, forward-thinking, highly collaborative team will contribute to the development of precision nutrition approaches that support optimal health across the adult lifespan.

项目总结 我们所有人新英格兰临床中心(AOU-NE-CC)是新英格兰研究中心的一个合作项目 在营养和临床转化科学方面拥有必要的专业知识和资源的团队 成功地完成了NIH共同基金精确健康营养(NPH)临床中心的所有三个模块 程序。美国农业部塔夫茨大学人体营养衰老研究中心(塔夫茨- HNRCA)和马萨诸塞州综合医院(MGH)将领导AOU-NE-CC并与我们所有人建立合作伙伴关系 英格兰确保参与者的多样性和确定个体间差异所需的科学严谨性 对饮食模式的反应。AOU-NE-CC致力于我们所有人的核心价值观，并已实施 团队科学在整个发展过程中的最佳实践。AOU-NE-CC将成为 制定严格的NPH通用方案并检查习惯性饮食摄入量(模块1)，测量 对混合膳食挑战的生理反应(模块1-3)，并确定对3种干预的反应 自由生活(模块2)和家养(模块3)的日粮控制饲养条件。再加上 我们所有人的标准数据，通过这些模块收集的生理反应将用于开发 预测算法，为长期健康的精确营养方法提供信息。要达到最大限度 代谢和微生物组反应的可变性，我们建议模块2的14天等卡路里饮食如下 3、为期4周的冲洗期：(1)控制高血压的高依从性饮食方法 (DASH)饮食；(2)低粘附性DASH饮食；以及(3)生酮饮食。我们还建议使用 经过全面测试的混合膳食挑战PhenFlex，可以跨临床中心标准化，以 提供代谢灵活性的多系统评估。凭借其出色的核心设施，包括 新陈代谢厨房和寄宿的喂养和护理中心，以及进行严格的 在喂养研究方面，AOU-NE-CC具有独特的技能和定位，可以作为NPH的临床中心。 AOU-NE-CC的其他优势包括在招募临床人群和 生物库，通过社区推广吸引志愿者，积极参与全球精准营养 计划，以及在营养、组学和营养领域富有成效的多站点合作的出色记录 精准健康。重要的是，塔夫茨-HNRCA和MGH团队与我们所有人都保持着密切的联系 英格兰队及其高招募和留住球员的记录及其多样化的队列，这将 支持NPH联盟的目标。通过与NPH和我们所有人合作，在这个新的模块发现中 科学研究，AOU-NE-CC及其经验丰富、前瞻性思维、高度合作的团队将做出贡献 发展精确营养方法，以支持成年人的最佳健康。