Genetic determinants of thoracic aortic stiffness and remodeling
胸主动脉僵硬度和重塑的遗传决定因素
基本信息
- 批准号:10539295
- 负责人:
- 金额:$ 19.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-01 至 2025-12-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAdoptionAdultAgeAgingAortaAortic SegmentAwardBiologicalClinicalClinical InvestigatorClinical SciencesCollaborationsDataDedicationsDepositionDevelopmentDiameterDistalDoctor of PhilosophyEFRACEchocardiographyElasticityElastinElectrocardiogramEnrollmentEnvironmentEpidemiologyEquationEquipmentExhibitsFacultyFemurFibrosisGenerationsGenetic DeterminismGenetic studyGenomicsGoalsHealthHeart failureHeritabilityHumanImageIndividualInstitutionK-Series Research Career ProgramsLeadershipLeftLengthLocationMagnetic Resonance ImagingMeasurementMeasuresMedicineMendelian randomizationMentorsMentorshipMethodologyMethodsMuscleParticipantPathologic ProcessesPatientsPennsylvaniaPhenotypePhysiciansPhysiologic pulsePlayPopulationPopulation StudyPrevention approachProcessProductivityProfessional OrganizationsResearchResearch PersonnelResourcesRespiratory DiaphragmRestRoleSample SizeScienceScientistSiteSurfaceSystemThoracic aortaTimeTrainingTraining SupportTranslational ResearchUniversitiesVentricularWorkage relatedaging populationaortic valvearterial tonometryascending aortabiobankburden of illnesscalcificationcareercareer developmentclinical imagingclinical practicedeep learningelectric impedanceepidemiology studyexomeexperiencegenome wide association studygenomic datahemodynamicsimaging studyimprovedinfancyinnovationinsightinterestlarge datasetsmedical schoolsmeetingsmid-career facultymultidisciplinarynext generationnext generation sequencingnovelpatient orientedpatient oriented researchpreservationprogramsprospectiveresearch and developmentresearch studyskillssuccesstime usetranslational studyultrasound
项目摘要
Project Summary / Abstract
This is an application for a K24 mentoring award for patient-oriented research (POR) from Julio Chirinos, MD,
PhD, Associate Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania
(Penn). Dr. Chirinos‘ long-term goals are to: (1) Substantially contribute to our understanding and approaches to
the prevention and treatment of aortic aging and its associated disease burden, and; (2) to mentor the next
generation of investigators interested in the epidemiology of aortic aging and its consequences in human health.
This mid-career development award will be critical to help him achieve these goals via dedicated/protected time
for mentoring activities, research and development of new skills that are anticipated to greatly enhance the
applicant’s impact in this field throughout the rest of his career, as well as the impact and success of his trainees.
The candidate has a strong record of mentorship, leadership, and research productivity. His research program
encompasses epidemiologic, translational and POR studies of arterial aging and its role in Heart Failure with
Preserved Ejection Fraction (HFpEF) and other conditions that afflict our aging population. The scientific goal of
this proposal is to investigate the genetic determinants of age-related thoracic aortic stiffening and elongation
using large available biobanks with associated genomic and aortic imaging data. These include the UK Biobank
and the Penn Medicine Biobank. The projects will include the application of a novel method for quantification of
aortic pulse wave velocity that can, for the first time, be applied retrospectively in widely available clinical imaging
studies. Deep learning for high-throughput aortic phenotyping will play an important role in this research. The
mentoring goals of this application are to engage and support the training of Penn fellows and junior faculty to
conduct POR in arterial aging. The career development goal of this application is to support the candidate’s
professional development and acquisition of new skills for POR research in aging, specifically: (1) genomics
(genome-wide association studies, next generation sequencing, and Mendelian Randomization); (2) Applied
deep learning to leverage large banks of imaging data in order to accomplish accurate high-throughput
phenotyping of aortic aging. This will be achieved through formal training courses and engaging in sustained
collaboration experiences with experts in these topics. The candidate will also engage in career development
and promotion of arterial aging research through convening scientific meetings on aortic aging research and
improving the national network of POR research in arterial aging through existing professional societies. The
institutional environment for clinical and translational science at Penn is outstanding. The Department of
Medicine at Penn has made a substantial commitment, including protected time and dedicated space, toward
the candidate’s sustained success as a patient-oriented researcher responsible for training a new generation of
junior investigators who conduct research in older participants.
项目总结/摘要
这是Julio Chirinos博士为面向患者的研究(POR)申请K24指导奖,
宾夕法尼亚大学佩雷尔曼医学院医学博士、副教授
(佩恩)。Chirinos博士的长期目标是:(1)为我们的理解和方法做出实质性贡献,
预防和治疗主动脉老化及其相关疾病负担,以及;(2)指导下一个
一代对主动脉衰老的流行病学及其对人类健康的后果感兴趣的研究人员。
这个职业生涯中期发展奖对于帮助他通过专用/受保护的时间实现这些目标至关重要
指导活动,研究和开发新的技能,预计将大大提高
申请人在其职业生涯中对该领域的影响,以及他的学员的影响和成功。
候选人有很强的指导,领导和研究生产力的记录。他的研究计划
包括动脉老化及其在心力衰竭中的作用的流行病学、转化和POR研究,
保留射血分数(HFpEF)和其他困扰我们老龄化人口的疾病。的科学目标
本研究旨在探讨与年龄相关的胸主动脉硬化和延长的遗传决定因素
使用具有相关基因组和主动脉成像数据的大型可用生物库。其中包括英国生物银行
和宾州医学生物库这些项目将包括应用一种新的方法,
主动脉脉搏波速度,首次可在广泛可用的临床成像中回顾性应用
问题研究高通量主动脉表型的深度学习将在这项研究中发挥重要作用。的
本申请的指导目标是参与和支持宾夕法尼亚大学研究员和初级教师的培训,
在动脉老化中进行POR。此应用程序的职业发展目标是支持候选人的
专业发展和获取新技能的POR研究在老龄化,特别是:(1)基因组学
(全基因组关联研究、下一代测序和孟德尔随机化);(2)应用
深度学习,利用大量成像数据,以实现准确的高通量
主动脉老化的表型。这将通过正规培训课程和参与持续的
与这些领域的专家合作。候选人还将从事职业发展
通过召开关于主动脉老化研究的科学会议,促进动脉老化研究,
通过现有的专业协会,改善动脉老化POR研究的国家网络。的
宾夕法尼亚大学临床和转化科学的机构环境是杰出的。部
宾夕法尼亚大学的医学已经做出了实质性的承诺,包括保护时间和专用空间,
候选人作为一个以病人为导向的研究人员,负责培养新一代的
在老年参与者中进行研究的初级研究人员。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JULIO ALONSO CHIRINOS MEDINA其他文献
JULIO ALONSO CHIRINOS MEDINA的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JULIO ALONSO CHIRINOS MEDINA', 18)}}的其他基金
Cardiovascular Risk, Vascular and Kidney Damage in COVID-19 Survivors
COVID-19 幸存者的心血管风险、血管和肾脏损伤
- 批准号:
10364096 - 财政年份:2022
- 资助金额:
$ 19.5万 - 项目类别:
Cardiovascular Risk, Vascular and Kidney Damage in COVID-19 Survivors
COVID-19 幸存者的心血管风险、血管和肾脏损伤
- 批准号:
10553207 - 财政年份:2022
- 资助金额:
$ 19.5万 - 项目类别:
Genetic determinants of thoracic aortic stiffness and remodeling
胸主动脉僵硬度和重塑的遗传决定因素
- 批准号:
10322755 - 财政年份:2021
- 资助金额:
$ 19.5万 - 项目类别:
Efficacy of Fenofibrate for COVID-19: A phase II randomized controlled trial
非诺贝特对 COVID-19 的疗效:II 期随机对照试验
- 批准号:
10245967 - 财政年份:2021
- 资助金额:
$ 19.5万 - 项目类别:
HeartShare: Next-Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets - Clinical Centers
HeartShare:定义心力衰竭亚型和治疗目标的下一代表型组学 - 临床中心
- 批准号:
10679106 - 财政年份:2021
- 资助金额:
$ 19.5万 - 项目类别:
HeartShare: Next-Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets - Clinical Centers
HeartShare:定义心力衰竭亚型和治疗目标的下一代表型组学 - 临床中心
- 批准号:
10327536 - 财政年份:2021
- 资助金额:
$ 19.5万 - 项目类别:
Efficacy of Fenofibrate for COVID-19: A phase II randomized controlled trial
非诺贝特对 COVID-19 的疗效:II 期随机对照试验
- 批准号:
10459754 - 财政年份:2021
- 资助金额:
$ 19.5万 - 项目类别:
HeartShare: Next-Generation Phenomics to Define Heart Failure Subtypes and Treatment Targets - Clinical Centers
HeartShare:定义心力衰竭亚型和治疗目标的下一代表型组学 - 临床中心
- 批准号:
10483139 - 财政年份:2021
- 资助金额:
$ 19.5万 - 项目类别:
Efficacy of Potassium Nitrate in Heart Failure with Preserved Ejection Fraction
硝酸钾治疗射血分数保留的心力衰竭的疗效
- 批准号:
8963158 - 财政年份:2015
- 资助金额:
$ 19.5万 - 项目类别:
Efficacy of Potassium Nitrate in Heart Failure with Preserved Ejection Fraction
硝酸钾治疗射血分数保留的心力衰竭的疗效
- 批准号:
9304280 - 财政年份:2015
- 资助金额:
$ 19.5万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 19.5万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 19.5万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 19.5万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 19.5万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 19.5万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 19.5万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 19.5万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 19.5万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 19.5万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 19.5万 - 项目类别:
Research Grant