Translating pharmacokinetic and pharmacodynamic data to better design new drugs for the treatment of Trypanosoma cruzi infection

治疗弓形虫感染的新药是迫切需要的，然而，由于对复杂的宿主-寄生虫相互作用的了解不完整，在药物发现过程中没有足够的体外和体内工具来严格定义活性，以及对浓度/效应关系的认识不足，这些药物的设计一直受到阻碍。该项目旨在开发新的和迫切需要的体外方法，以更好地确定新药候选的动力学和动态活性，并将为将这些信息转化为长时间的旋毛虫感染动物模型提供合理的基础。其结果旨在设计合理的候选药物，在较短的时间内可供使用，并适合进一步开发。

New drugs to treat T. cruzi infection are urgently needed, however their design has been hampered by an incomplete understanding of complex host-parasite interactions, inadequate in vitro and in vivo tools to rigorously define activity during drug discovery, and a poor appreciation of concentration/effect relationships. This project aims to develop new and much needed in vitro methods to better define the kinetic and dynamic activity of new drug candidates, and will provide a rational basis for translating this information into lengthy animal models of T. cruzi infection. The outcome aims to be rationally designed drug candidates that are available in a shorter period of time and are suitable for further development.