Translating pharmacokinetic and pharmacodynamic data to better design new drugs for the treatment of Trypanosoma cruzi infection

转化药代动力学和药效学数据以更好地设计治疗克氏锥虫感染的新药

• 批准号: LP140100560
• 负责人: Prof Susan Charman
• 金额: $ 35.75万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-06 至 2017-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP140100560
• 关键词: Translating; pharmacokinetic; pharmacodynamic; data; better

New drugs to treat T. cruzi infection are urgently needed, however their design has been hampered by an incomplete understanding of complex host-parasite interactions, inadequate in vitro and in vivo tools to rigorously define activity during drug discovery, and a poor appreciation of concentration/effect relationships. This project aims to develop new and much needed in vitro methods to better define the kinetic and dynamic activity of new drug candidates, and will provide a rational basis for translating this information into lengthy animal models of T. cruzi infection. The outcome aims to be rationally designed drug candidates that are available in a shorter period of time and are suitable for further development.

治疗T. Cruzi感染，但是它们的设计受到以下因素的阻碍：对复杂的宿主-寄生虫相互作用的不完全理解，在药物发现期间严格定义活性的体外和体内工具不足，以及对浓度/效应关系的认识不足。该项目旨在开发新的和急需的体外方法，以更好地定义新候选药物的动力学和动态活性，并将为将这些信息转化为T.克氏感染该结果旨在合理设计候选药物，在较短的时间内可用，并适合进一步开发。