New York City Virus Hunters - A Community Science Initiative

纽约市病毒猎人 - 社区科学倡议

• 批准号: 10665143
• 负责人: Florian Krammer
• 金额: $ 27.18万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-11 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665143
• 关键词: Adult; Avulavirus; Awareness; Bioinformatics; Birds; Collaborations; Collection; Columbidae; Communication; Communities; Data; Data Analyses; Data Collection; Development; Disadvantaged; Drops; Education; Education and Outreach; Educational Curriculum; Educational process of instructing; Educational workshop; Ensure; Environment; Equipment; Event; Experimental Designs; Feces; Fostering; Genbank; Goals; Health; High School Student; Human; Individual; Infrastructure; Institution; Internet; Internships; Knowledge; Laboratories; Learning; Mentors; Mentorship; Methods; Middle School Student; Modernization; Molecular; Molecular Biology; New York; New York City; Newcastle disease virus; Nucleic Acids; Participant; Peer Review; Phase; Phylogenetic Analysis; Process; Protocols documentation; Publications; Race; Research; Research Design; Research Infrastructure; STEM career; Sampling; Schools; Science; Scientist; Sequence Analysis; Structure; Student recruitment; Students; System; Teacher Professional Development; Techniques; Training; Underrepresented Minority; Underrepresented Populations; Universities; Update; Viral; Virus; Work; Youth; after-school program; broadening participation research; community organizations; community science; data dissemination; design; future pandemic; health literacy; high school; influenzavirus; innovation; interest; junior high school; learning engagement; medical schools; member; next generation; novel therapeutics; novel vaccines; nucleic acid detection; peer; personalized approach; prevent; programs; recruit; sample collection; service learning; symposium; teacher; university student; urban area; virology

PROJECT ABSTRACT We aim to increase student’s understanding and interest in science through active participation in the first large- scale surveillance initiative targeting avian viruses like influenza viruses (AIV) and avian paramyxoviruses (APMV, also known as Newcastle disease virus) ever conducted in an urban area - New York City (NYC) - via analysis of bird droppings. The New York City Virus Hunters (NYCVH) initiative will enable teachers, students and interested community members to gain an understanding of the interaction of natural environments and human health, while increasing their knowledge, confidence, and interest in science. The NYCVH initiative will build on strong collaborations between the Krammer Laboratory at the Icahn School of Medicine at Mount Sinai (ISMMS), a globally leading laboratory in virology, and BioBus, a leading NYC science outreach and education institution. NYCVH will develop and provide all the training, equipment, materials, and infrastructure needed to support this large-scale, community-science-driven research effort. NYCVH will be designed to offer multiple entry points and levels of engagement for interested community scientists - such as students, teachers or community members - to participate. Trainings will ensure that interested teachers gain an understanding of modern viral surveillance techniques and have ways to easily incorporate NYCVH program aspects of their choice into their work. Over the course of the program, 6000 middle and high school students will be led by 100 teachers trained at workshops held at BioBus’s BioBase Harlem inside Columbia University’s Zuckerman Institute. Workshops will introduce teachers to modern viral surveillance using molecular techniques, experimental design, laboratory and bioinformatics methods, sampling kit components, and detail how teachers and students can participate in research to prevent the next pandemic. Through BioBus’ network we will enlist partner schools to broaden participation in the program including through large-scale sampling events. In addition, and importantly, 25 high school students from historically underrepresented communities in science will be trained to spearhead the initiative as Junior Research Scientists who will join the NYCVH as interns over the academic year and get an intensive training in sampling, nucleic acid detection, sequencing, phylogenetic analysis and virology in general to become the next generation of leading virologists. With ISMMS, BioBus and plus a network of scientists from academic institutions and wildlife rehabilitators, those students will be supported throughout their research process – study design, sample collection, sample processing, analyzing results, and presenting their research at symposia. This project will be evaluated using a mixed-methods approach tailored to understanding the impact of program participation on all individuals. The structure of this program is designed to determine the feasibility and impact of large-scale studies at the urban human – avian interface through participatory research, and influence on student’s long-term STEM career goals.

项目摘要 我们的目标是通过积极参与第一次大型的科学活动，增加学生对科学的理解和兴趣- 针对禽流感病毒和禽副粘病毒等禽流感病毒的大规模监测举措 (APMV，也称为纽卡斯尔病病毒）在城市地区-纽约市（NYC）-通过 鸟粪的分析纽约市病毒猎人（NYCVH）计划将使教师、学生 和感兴趣的社区成员，以了解自然环境的相互作用， 人类健康，同时增加他们的知识，信心和对科学的兴趣。 NYCVH计划将建立在伊坎学院Krammer实验室与 西奈山医学（ISMMS），一个全球领先的病毒学实验室，和BioBus，一个领先的纽约科学 外展和教育机构。NYCVH将开发和提供所有的培训，设备，材料， 这是支持这一大规模、社区科学驱动的研究工作所需的基础设施。NYCVH将是 旨在为感兴趣的社区科学家提供多个切入点和参与级别-例如 学生，教师或社区成员-参与。培训将确保有兴趣的教师获得 了解现代病毒监测技术，并有方法轻松纳入NYCVH计划 把自己的选择融入到工作中。在这个项目的过程中，6000名初中和高中学生 将由100名教师领导，他们在哥伦比亚大学内部的生物巴士生物基地哈莱姆举行的研讨会上接受了培训。 朱克曼研究所。研讨会将向教师介绍使用分子技术的现代病毒监测， 实验设计，实验室和生物信息学方法，采样试剂盒的组成部分，并详细说明如何教师 学生们可以参与研究，以防止下一次大流行。通过BioBus的网络， 伙伴学校扩大参与该方案，包括通过大规模抽样活动。在 此外，重要的是，25名来自历史上科学代表性不足的社区的高中生将 接受培训，作为初级研究科学家带头倡议，他们将作为实习生加入NYCVH 一个学年，并得到密集的培训，在采样，核酸检测，测序，系统发育 分析和病毒学，成为下一代领先的病毒学家。随着ISMMS，BioBus和 加上来自学术机构的科学家和野生动物康复者的网络，这些学生将得到支持， 在整个研究过程中-研究设计，样本收集，样本处理，分析结果， 在研讨会上展示他们的研究。 该项目将使用混合方法进行评估，以了解计划的影响 所有个人的参与。本方案的结构设计是为了确定可行性和影响 通过参与性研究在城市人-鸟界面进行大规模研究， 学生的长期职业目标。