New York City Virus Hunters - A Community Science Initiative

项目摘要 我们的目标是通过积极参与第一个大型的- 针对流感病毒(AIV)和副粘病毒等禽流感病毒的规模监测倡议 (APMV，也称为新城疫病毒)曾在城市地区-纽约市(NYC)-通过 鸟类粪便的分析。纽约市病毒猎人(NYCVH)倡议将使教师、学生 和感兴趣的社区成员了解自然环境和 人类健康，同时增加他们对科学的知识、信心和兴趣。 NYCVH计划将建立在伊坎学院克拉默实验室之间强有力的合作基础上 西奈山医学(ISMMS)，全球领先的病毒学实验室，以及纽约市领先的科学BioBus 外展和教育机构。NYCVH将开发和提供所有培训、设备、材料和 需要基础设施来支持这种大规模的、社区科学驱动的研究工作。NYCVH将是 旨在为感兴趣的社区科学家提供多个切入点和参与程度-例如 学生、教师或社区成员--参与其中。培训将确保有兴趣的教师获得 了解现代病毒监测技术，并有办法轻松纳入NYCVH计划 把他们的选择融入到他们的工作中。在该计划的过程中，6000名初中生和高中生 将由100名教师领导，这些教师在哥伦比亚大学哈莱姆区BioBus生物基地举行的研讨会上接受培训 扎克曼研究所。研讨会将向教师介绍使用分子技术进行现代病毒监测， 实验设计，实验室和生物信息学方法，采样试剂盒组件，以及详细说明教师如何 学生还可以参与预防下一次大流行的研究。通过BioBus的网络，我们将招募 合作学校扩大对该方案的参与，包括通过大规模抽样活动。在……里面 此外，重要的是，来自科学界历史上代表性不足的社区的25名高中生将 接受培训，作为初级研究科学家带头开展这项活动，他们将以实习生的身份加入NYCVH 一学年，接受采样、核酸检测、测序、系统发育方面的强化培训 分析和病毒学一般成为下一代领先的病毒学家。使用ISMMS、BioBus和 加上学术机构的科学家和野生动物康复者组成的网络，这些学生将得到支持 在整个研究过程中-研究设计、样本收集、样本处理、分析结果，以及 在座谈会上展示他们的研究成果。 该项目将使用混合方法进行评估，以了解计划的影响 所有个人都可以参与。这一方案的结构设计是为了确定其可行性和影响 通过参与性研究在城市人-鸟界面进行大规模研究，以及对 学生的长期STEM职业目标。

PROJECT ABSTRACT We aim to increase student’s understanding and interest in science through active participation in the first large- scale surveillance initiative targeting avian viruses like influenza viruses (AIV) and avian paramyxoviruses (APMV, also known as Newcastle disease virus) ever conducted in an urban area - New York City (NYC) - via analysis of bird droppings. The New York City Virus Hunters (NYCVH) initiative will enable teachers, students and interested community members to gain an understanding of the interaction of natural environments and human health, while increasing their knowledge, confidence, and interest in science. The NYCVH initiative will build on strong collaborations between the Krammer Laboratory at the Icahn School of Medicine at Mount Sinai (ISMMS), a globally leading laboratory in virology, and BioBus, a leading NYC science outreach and education institution. NYCVH will develop and provide all the training, equipment, materials, and infrastructure needed to support this large-scale, community-science-driven research effort. NYCVH will be designed to offer multiple entry points and levels of engagement for interested community scientists - such as students, teachers or community members - to participate. Trainings will ensure that interested teachers gain an understanding of modern viral surveillance techniques and have ways to easily incorporate NYCVH program aspects of their choice into their work. Over the course of the program, 6000 middle and high school students will be led by 100 teachers trained at workshops held at BioBus’s BioBase Harlem inside Columbia University’s Zuckerman Institute. Workshops will introduce teachers to modern viral surveillance using molecular techniques, experimental design, laboratory and bioinformatics methods, sampling kit components, and detail how teachers and students can participate in research to prevent the next pandemic. Through BioBus’ network we will enlist partner schools to broaden participation in the program including through large-scale sampling events. In addition, and importantly, 25 high school students from historically underrepresented communities in science will be trained to spearhead the initiative as Junior Research Scientists who will join the NYCVH as interns over the academic year and get an intensive training in sampling, nucleic acid detection, sequencing, phylogenetic analysis and virology in general to become the next generation of leading virologists. With ISMMS, BioBus and plus a network of scientists from academic institutions and wildlife rehabilitators, those students will be supported throughout their research process – study design, sample collection, sample processing, analyzing results, and presenting their research at symposia. This project will be evaluated using a mixed-methods approach tailored to understanding the impact of program participation on all individuals. The structure of this program is designed to determine the feasibility and impact of large-scale studies at the urban human – avian interface through participatory research, and influence on student’s long-term STEM career goals.