Activation of BMP4 signalling to inhibit breast cancer metastasis

激活BMP4信号抑制乳腺癌转移

• 批准号: nhmrc : GNT1121199
• 负责人: A/Pr Andrew Redfern
• 金额: $ 74.87万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/activation-bmp4-signalling-cancer-metastasis/1347191
• 关键词: Activation; BMP4; signalling; inhibit; breast

The spread of cancer cells to other organs is a common cause of breast cancer-related death in women. Current therapies for advanced breast cancer are often palliative since the secondary tumours become resistant to the chemotherapy. Here, we are using preclinical models of advanced breast cancer to develop a treatment that should be effective in patients with secondary tumours and should reduce the risk of dying of this disease.

癌细胞扩散到其他器官是女性乳腺癌相关死亡的常见原因。目前晚期乳腺癌的治疗通常是姑息性的，因为继发性肿瘤对化疗产生了耐药性。在这里，我们正在使用晚期乳腺癌的临床前模型来开发一种治疗方法，这种治疗方法应该对继发性肿瘤患者有效，并且应该降低死于这种疾病的风险。