Enhancing Research capacity for Sickle Cell Disease and related NCDs across the Lifespan in Uganda. ''Enrich Project''

加强乌干达全生命周期镰状细胞病和相关非传染性疾病的研究能力。

• 批准号: 10665128
• 负责人: Sarah Kiguli
• 金额: $ 24.73万
• 依托单位: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665128
• 关键词: Accounting; Acute Renal Failure with Renal Papillary Necrosis; Adult; Advocacy; Affect; Africa; Africa South of the Sahara; Brain; Cessation of life; Child; Childhood; Chronic; Disease; Growth; Health Sciences; Heart; High Prevalence; Home; Intervention; Kidney; Life Expectancy; Longevity; Lung; Microalbuminuria; Morbidity - disease rate; Neurocognitive Deficit; Nutritional; Patients; Perinatal; Persons; Population; Professional Education; Research; Research Training; Scientist; Sickle Cell Anemia; Stroke; Survivors; Training; Uganda; Universities; Work; acute chest syndrome; clinical care; college; cost; health related quality of life; innovation; mortality; multidisciplinary

Project Abstract: Chronic Non-communicable Diseases and Disorders (NCDs) are the leading cause of global mortality, accounting for 71% of all deaths. It is projected that by 2030, deaths from NCDs in Africa will exceed deaths due to communicable, maternal, perinatal, and nutritional diseases combined. Sub-Saharan Africa is home to 90% of the 300,000 children born worldwide with Sickle Cell Disease (SCD) annually and SCD in Sickle Cell Anemia SSA is associated with 16% of childhood mortality . SCD is both an NCD and a recognized as a significant cause of NCD-related morbidity and mortality in persons with (SSA). SCD related NCDs have been observed in the brain, kidneys, heart, and lungs. The overall objective of the work that is proposed in this application is to enhance the SCD associated NCD research capacity in Uganda. This has been informed by the following observations: (a) SCD is very common, affecting over 350,000 people in Uganda, and accounts for 18% of all childhood morbidity . SCD is also associated with reduced life expectancy and poor health related quality of life for survivors. (b) Previous studies on children and adults with SCD in Uganda have highlighted a high prevalence of stroke (6.8%), neurocognitive impairment (21.5%), acute chest syndrome (22.7%), micro-albuminuria, and acute kidney injury. The team will work to achieve the overall objective through the following aims: Aim 1: To train a multi-disciplinary team of research scientists. Aim 2: To increase SCD and associated NCD research capacity across the lifespan. Aim 3: To strengthen local and regional partnerships for advancing SCD and associated NCD research training and advocacy. The activities in this application innovatively exploit the access to large numbers of SCD patients and the multi-disciplinary/inter professional education expertise at Makerere University College of Health Sciences and Busitema University, both in Uganda to increase the local SCD associated NCD research capacity. It is anticipated that by the end of the 5-years support, a critical mass of local research scientists will have been created to support the further growth of a high quality SCD associated NCDs research and clinical care portfolio, focused on low-cost sustainable interventions for SCD affected populations in Uganda and other settings including the USA. 1

项目摘要： 慢性非传染性疾病和疾病是全球死亡的主要原因， 占所有死亡人数的71%。预计到2030年，非洲死于非传染性疾病的人数将超过 传染病、孕产妇、围产期和营养性疾病造成的死亡人数合计。 撒哈拉以南非洲 是世界上90%的 全球每年有300,000名出生时患有镰状细胞病(SCD)的儿童 在……里面 镰状细胞性贫血SSA与16%的儿童死亡率有关 。SCD既是一种非传染病，也是一种 被认为是与非传染性疾病相关的发病率和死亡率的一个重要原因。SCD 相关的非传染性疾病已经在大脑、肾脏、心脏和肺中被观察到。工作的总目标 在本申请中提出的这一建议是为了加强乌干达与SCD相关的非传染性疾病研究能力。 根据以下观察所得：(A)SCD非常普遍，影响超过350,000人 占所有儿童发病率的18% 。SCD也与减少 幸存者的预期寿命和与健康相关的不良生活质量。(B)以前关于儿童的研究和 乌干达患有SCD的成年人强调中风(6.8%)、神经认知障碍的高患病率 (21.5%)、急性胸部综合征(22.7%)、微量白蛋白尿、急性肾损伤。该团队将致力于 通过以下目标实现总体目标：目标1：培养一支多学科的团队 研究科学家。目标2：在整个生命周期内增加SCD和相关的NCD研究能力。 目标3：加强地方和区域伙伴关系，推进可持续发展和相关的非传染性疾病研究 培训和宣传。此应用程序中的活动创新性地利用了对大量 Makerere大学的SCD患者和多学科/跨专业的教育专长 健康科学学院和布希特马大学，都在乌干达增加了当地的SCD相关 非传染性疾病研究能力。预计到5年支持结束时，将有相当数量的地方 将创建研究科学家，以支持与高质量SCD相关的进一步增长 非传染性疾病研究和临床护理组合，重点是针对受影响的SCD的低成本可持续干预 乌干达和包括美国在内的其他地区的人口。 1