The vaginal microenvironment in asymptomatic versus symptomatic bacterial vaginosis

无症状与有症状细菌性阴道病的阴道微环境

基本信息

  • 批准号:
    10666011
  • 负责人:
  • 金额:
    $ 27.82万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-03-01 至 2025-02-28
  • 项目状态:
    未结题

项目摘要

Bacterial vaginosis (BV), which is characterized by a dysbiotic vaginal microbiota low in Lactobacillus species, affects nearly 30% of U.S. women; the majority (55%) are asymptomatic (aBV). Guidelines currently recommend testing and treatment only for symptomatic BV (sBV). BV (a composite variable with aBV and symptomatic BV [sBV]) has been associated with an increased risk of sexually transmitted infections (STIs) and HIV acquisition. Although studies to distinguish the differential risk of incident STI or HIV between women with aBV and sBV have not been published, preliminary data from our group suggests that aBV is strongly associated with incident STI and a published pilot study of BV suppressive therapy in women with aBV indicated a decrease in chlamydia cases. To date, enthusiasm for research on or clinical treatment of aBV has been limited, primarily by lack of data on aBV risks and perceptions of low efficacy of currently available BV treatments. However, while BV treatment is challenging, approximately 50% of women with sBV taking currently available therapies do achieve lasting cure. Moreover, novel, more effective therapies for BV are on the horizon: a recent high-profile randomized trial of Lactin V, a L. crispatus intravaginal live biotherapeutic product, showed reduced BV recurrence13. As new, better treatments for sBV become available, it is critical to determine whether women with aBV should also be treated, in order to prevent sequelae such as STI or HIV acquisition. If the vaginal microenvironment is shown to be identical in women with sBV and aBV, this will be an important initial step demonstrating that aBV is a condition that should not be ignored, and will galvanize further studies to define aBV, STI and HIV risk, and advance treatment. In a large epidemiologic study of over 300 women, our specific aims are to assess whether women with aBV and sBV differ in two broad areas (1) biobehavioral factors and (2) the vaginal microenvironment, including factors associated with HIV and STI acquisition risk (vaginal microbiota, key metabolites and soluble mediators of inflammation). This is a secondary analysis leveraging existing data from a previously funded study (NIAID R01-AI116799, PI: Brotman) for which 16S rRNA gene amplicon, metabolomic, and immunologic profiles have already been generated from cervicovaginal lavage samples collected in the NIH's Longitudinal Study of Vaginal Flora. Information gained through this proposed study will provide foundational data to better define aBV, and to determine whether future studies to define the risk of HIV and STI acquisition associated with aBV, or studies of aBV treatment as a method to prevent HIV and STIs are needed. This resubmission application is in response to a program announcement (PAR-20-291) which is designed for Exploratory and Developmental Research Grant Program for NIAID K-award Recipients. It will provide career development for the PI to transition to research independence with a highly feasible and valuable clinical research project focused on the vaginal microbiome and women's health.
细菌性阴道病(BV),其特点是阴道菌群缺乏乳酸杆菌,

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Susan Anne Tuddenham其他文献

Susan Anne Tuddenham的其他文献

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{{ truncateString('Susan Anne Tuddenham', 18)}}的其他基金

The rectal microbiome and incident rectal sexually transmitted infections
直肠微生物组和直肠性传播感染事件
  • 批准号:
    10349502
  • 财政年份:
    2021
  • 资助金额:
    $ 27.82万
  • 项目类别:
Dysbiosis, Recurrent Bacterial Vaginosis and the Vaginal Microbiome
菌群失调、复发性细菌性阴道病和阴道微生物组
  • 批准号:
    9297211
  • 财政年份:
    2016
  • 资助金额:
    $ 27.82万
  • 项目类别:
Dysbiosis, Recurrent Bacterial Vaginosis and the Vaginal Microbiome
菌群失调、复发性细菌性阴道病和阴道微生物组
  • 批准号:
    9163096
  • 财政年份:
    2016
  • 资助金额:
    $ 27.82万
  • 项目类别:
Dissemination Core
传播核心
  • 批准号:
    10714420
  • 财政年份:
    2007
  • 资助金额:
    $ 27.82万
  • 项目类别:

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