Genomics-Accelerated Discovery and Biosynthesis of Phosphonic Acid Natural Products
基因组学-膦酸天然产物的加速发现和生物合成
基本信息
- 批准号:10665605
- 负责人:
- 金额:$ 30.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-15 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationActinobacteria classAcuteAgricultureAminationAmino AcidsAnabolismAntibioticsAntimalarialsAntimicrobial ResistanceArginineBiochemicalBiochemistryBiologicalBiotechnologyCarbonChemicalsClassificationClassification SchemeCommunicable DiseasesDNA SequenceDevelopmentDwarfismEngineeringEnzymatic BiochemistryEnzymesEstersFamilyFutureGene ClusterGeneticGenetic VariationGenomeGenomicsGoalsHealthHemeHumanHydroxylationInfectionKnowledgeLigaseLigationMedicineMetabolicMiningModificationMolecularMolecular TargetNatural ProductsNatureOutcomeOxidoreductasePathway interactionsPeptidesPhosphonic AcidsPhosphorusPropertyResearchRouteSourceStreamSubstrate SpecificitySystemTransfer RNAViralantimicrobialcommercializationdrug developmenteffective therapygenomic datagrasphuman mortalityimprovedinnovationinsightinterestmicrobialmicrobial genomemicrobial genomicsmimicrymulti-drug resistant pathogennovelpharmacophorephosphonatepublic repositoryresponse
项目摘要
PROJECT SUMMARY
Microbial phosphonic acids are a class of understudied natural products with significant utility in medicine. The
antimicrobial, antiviral, and antimalarial activity of many useful phosphonic acids derives from potent and
specific inhibition of metabolic enzymes through chemical mimicry of their natural substrates. These properties,
along with the trove of novel biosynthetic gene clusters encoded within microbial genomic datasets, highlight
their potential of phosphonic acid natural products new antimicrobials. In this project we focus our efforts on
realizing their genomic potential of these compounds by establishing fundamental genetic and biochemical
principles that define their biosynthetic and bioactivity landscape. Filling these gaps in knowledge will provide a
systems-level understanding of natural product biosynthesis necessary to improve discovery and engineering
of new phosphonic acids. Specifically, we investigate three recently discovered phosphonic acid peptides to
uncover unusual hydroxylation, reduction, amination, and amino acid ligation enzymes, and the molecular
basis of their antimicrobial activity. We expand and refine the framework for phosphonic acid natural product
genomics through the isolation of new compounds from cryptic gene clusters, discovery of new pathways and
enzymes for C-P bond formation, and the development of a classification scheme to improve prediction of
phosphonic acid gene clusters and their chemical products.
项目总结
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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Genomics-Accelerated Discovery and Biosynthesis of Phosphonic Acid Natural Products
基因组学-膦酸天然产物的加速发现和生物合成
- 批准号:
10798945 - 财政年份:2020
- 资助金额:
$ 30.43万 - 项目类别:
Genomics-Accelerated Discovery and Biosynthesis of Phosphonic Acid Natural Products
基因组学-膦酸天然产物的加速发现和生物合成
- 批准号:
10449297 - 财政年份:2020
- 资助金额:
$ 30.43万 - 项目类别:
Genomics-Accelerated Discovery and Biosynthesis of Phosphonic Acid Natural Products
基因组学-膦酸天然产物的加速发现和生物合成
- 批准号:
10260569 - 财政年份:2020
- 资助金额:
$ 30.43万 - 项目类别:
Discovery and Characterization of Novel Nitroaromatic Antibiotics
新型硝基芳香族抗生素的发现和表征
- 批准号:
8397213 - 财政年份:2013
- 资助金额:
$ 30.43万 - 项目类别:














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