TRAF7突变侵袭性脑膜瘤的分子机制-猫眼课题宝

TRAF7突变侵袭性脑膜瘤的分子机制

批准号：

10665542

负责人：

MURAT GUNEL

金额：

$50.86万

依托单位：

YALE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2020

资助国家：

美国

项目状态：

未结题

起止时间：

2020-07-01 至 2025-04-30

来源：

https://reporter.nih.gov/project-details/10665542

关键词：

Acute Adult Anaplastic Meningioma Animal Model Architecture Automobile Driving Benign Benign Meningiomas Biochemical Biological Assay Blood - brain barrier anatomy Brain Brain Neoplasms Cell Line Cell Proliferation Cells ChIP-seq Clinical Trials Code Collection DNA Methylation Deubiquitinating Enzyme Drug Targeting Effectiveness Event Excess Mortality Future Genes Genital Genitalia Genomic approach Genomics Glioblastoma Glioma Hand Histologic Histology Human Incidence Intracranial Neoplasms Intraneural perineurioma Invaded Malignant - descriptor Meningeal Mesothelioma Molecular Morbidity - disease rate Mutate Mutation NF-kappa B Neurofibromin 2 Neurologic Neurologic Deficit Oncogenic Operative Surgical Procedures PIK3CG gene Pathway interactions Patients Pharmaceutical Preparations Population Primary Brain Neoplasms Principal Investigator Public Health Radiation Recurrence Recurrent tumor Reporting Research Resected Role Signal Pathway Signaling Molecule Stroke Structure Subgroup Testing Therapeutic United States Untranslated RNA adenoma candidate validation driver mutation drug efficacy efficacy testing epigenomics exome exome sequencing genomic profiles inhibitor insight meningioma mouse model mutant neurovascular new therapeutic target next generation sequencing novel therapeutics programs protein function response skull base subcutaneous transcriptome sequencing tumor tumor progression ubiquitin isopeptidase ubiquitin ligase ubiquitin-protein ligase whole genome

项目摘要

项目成果

MURAT GUNEL的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

PROJECT SUMMARY / ABSTRACT Meningiomas are the most common primary brain tumors. While typically of benign histology, they can be associated with significant neurological morbidity and have the potential for malignant transformation. In our previous studies, we completed genomic analysis of over 700 meningiomas using whole exome and targeted next-generation sequencing, identifying driver mutations in 12 genes and establishing mutually exclusive molecular subgroups. We now propose to investigate the molecular mechanisms underlying the formation of TRAF7-dependent meningiomas (which represent up to one quarter of all meningiomas), undertake molecular genomic analyses to identify somatic coding and non-coding or genomic events in TRAF7 tumors that progress to higher grades. We also propose to test and validate candidate drug efficacy using primary cultures from surgically resected meningiomas carrying TRAF7 aberrations, as well as mouse models of meningioma that we have established.

期刊论文(1)

专著(0)

科研奖励(0)

会议论文

Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease.

DOI： 10.1073/pnas.2214997120

发表时间： 2023-04-18

期刊：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

影响因子： 11.1

作者：

[Mishra-Gorur, Ketu, Barak, Tanyeri, Kaulen, Leon D., Henegariu, Octavian, Jin, Sheng Chih, Aguilera, Stephanie Marie, Yalbir, Ezgi, Goles, Gizem, Nishimura, Sayoko, Miyagishima, Danielle, Djenoune, Lydia, Altinok, Selin, Rai, Devendra K., Viviano, Stephen, Prendergast, Andrew, Zerillo, Cynthia, Ozcan, Kent, Baran, Burcin, Sencar, Leman, Goc, Nukte, Yarman, Yanki, Ercan-Sencicek, A. Gulhan, Bilguvar, Kaya, Lifton, Richard P., Moliterno, Jennifer, Louvi, Angeliki, Yuan, Shiaulou, Deniz, Engin, Brueckner, Martina, Gunel, Murat]

通讯作者： Gunel, Murat