Dominantly Inherited Alzheimer Network: Cognition Core

显性遗传阿尔茨海默病网络：认知核心

• 批准号: 10665742
• 负责人: Jason J Hassenstab
• 金额: $ 53.2万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665742
• 关键词: Adherence; Alzheimer' s Disease; Attention; Biological Markers; Categories; Cellular Phone; Certification; Characteristics; Charge; Clinic; Clinical; Clinical Trials; Cognition; Cognitive; Cognitive Science; Communication; Consultations; Consumption; Data; Data Analyses; Data Set; Dedications; Development; Distributed Systems; Documentation; Drops; Ensure; Episodic memory; Evaluation; Freezing; Funding; Goals; Good Clinical Practice; Grant; Home; Industry; Inherited; Institution; Learning; Linguistics; Maintenance; Manuscripts; Measurement; Measures; Memory; Methodology; Methods; Mission; Modification; Neuropsychology; Online Systems; Participant; Personal Computers; Pilot Projects; Population; Preparation; Procedures; Process; Protocols documentation; Psychometrics; Quality Control; Registries; Reproducibility; Research; Research Personnel; Running; Semantics; Site; System; Technology; Testing; Time; Training; Translations; Validation; Work; autosomal dominant Alzheimer' s disease; cognitive change; cognitive process; cognitive testing; computerized; forgetting; implicit memory; improved; insight; instrument; novel; pre-clinical; processing speed; remote administration; remote grading; smartphone application; standard measure; web-based assessment

Core H: Cognition SUMMARY The Cognition Core of the Dominantly Inherited Alzheimer Network (DIAN) is a newly formed core that will serve the overall grant by overseeing rater training and maintaining rigorous quality control (QC) and documentation standards that ensure the fidelity of longitudinal cognitive assessments. A primary goal of the core is to revise the cognitive assessment battery to align with scientific aims and minimize participant burden. We will remove burdensome and insensitive measures and incorporate novel measures and novel assessment methodologies that are more sensitive to early cognitive changes. These methodologies will improve reliability in measurement of the key features of autosomal dominant Alzheimer disease (ADAD). The assessment of cognition is central for achieving the scientific aims of all DIAN Projects and Cores. The Cognition Core will work with the Project and Core leaders to ensure that fully validated cognitive data is available for DIAN data freezes and provide guidance on appropriate cognitive measures and data analyses to support project and core aims. Due to the unique value of the ADAD population, there is great enthusiasm from DIAN investigators and external investigators to add novel cognitive measures to DIAN. However, any revisions or additions to the battery can be extraordinarily complicated in a global study like DIAN. The Cognition Core has formed an advisory board including leaders in clinical neuropsychology and cognitive psychology from academic institutions and industry who have specific expertise in global AD studies, clinical trials, computerized assessment, and remote technologies. In consultation with the advisory board, the Cognition Core has developed a formalized process for evaluating, piloting, and integrating new cognitive measures. This process involves scrutiny of preliminary data, test characteristics, availability of translations and suitability for remote test administration. A goal of the DIAN renewal is to harmonize DIAN across all affiliated studies to maximize the power of this remarkable dataset for insights into the essential characteristics of ADAD and to support more effective clinical trials. A dedicated Cognition Core serves this mission directly by creating multiple efficiencies across DIAN, the DIAN-Trials Unit (DIAN-TU) and the DIAN Expanded Registry (DIAN EXR). Core measures of the cognitive assessment battery in DIAN formed the basis for the DIAN-TU battery, but there remain crucial differences in the assessments collected, differences in rater training and certification, differences in QC processes, and DIAN only recently has implemented a rigorous system of documentation. A dedicated core will align these procedures, improve QC processes, and facilitate communications between sites and the DIAN Coordinating Center, thus achieving a critical aim of the core: to improve the rigor and reproducibility of cognitive data collected across all DIAN studies.

核心H：认知总结 显性遗传性阿尔茨海默病网络的认知核心是一个新形成的核心，它将 通过监督评分员培训和保持严格的质量控制(QC)和 确保纵向认知评估的准确性的文件标准。的主要目标是 核心是修改认知评估单元，以与科学目标保持一致，并将参与者的负担降至最低。 我们将取消繁重和不敏感的措施，纳入新措施和新评估 对早期认知变化更敏感的方法。这些方法将提高可靠性 在衡量常染色体显性遗传性阿尔茨海默病(ADAD)的关键特征方面。评估 认识是实现所有DIAN项目和核心的科学目标的核心。认知核心意志 与项目和核心领导合作，确保完全有效的认知数据可用于DIAN数据 冻结并就适当的认知措施和数据分析提供指导，以支持项目和 核心目标。 由于ADAD种群的独特价值，DIAN调查人员和 外部调查人员将为DIAN增加新的认知措施。但是，对 在像DIAN这样的全球研究中，电池可能会变得异常复杂。认知核心已经形成了一种 顾问委员会包括临床神经心理学和认知心理学的领导者来自学术界 在全球AD研究、临床试验、计算机化方面拥有特定专业知识的机构和行业 评估和远程技术。在与顾问委员会协商后，认知核心已经 为评估、引导和整合新的认知测量制定了一个正式的过程。这一过程 包括审查初步数据、测试特征、翻译的可用性以及是否适合远程 测试管理。 DIAN更新的目标是在所有附属研究中协调DIAN，以最大限度地发挥DIAN的力量 卓越的数据集，可深入了解ADAD的基本特征并支持更有效的临床 审判。一个专门的认知核心直接服务于这一使命，通过在DIAN、 Dian-Trials股(DIAN-TU)和DIAN扩展登记处(DIAN EXR)。认知能力的核心衡量标准 DIAN的评估电池构成了DIAN-TU电池的基础，但在 收集的评估、评分员培训和认证的差异、质量控制流程的差异，以及 直到最近，Dian才实施了一套严格的文件系统。一个专用的核心将使这些 程序，改进QC流程，并促进现场和DIAN协调之间的沟通 中心，从而实现了核心的一个关键目标：提高认知数据的严密性和可重复性 从所有的DIAN研究中收集的。