Dominantly Inherited Alzheimer Network: Cognition Core

显性遗传阿尔茨海默病网络：认知核心

• 批准号: 10017839
• 负责人: Jason J Hassenstab
• 金额: $ 15.59万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10017839
• 关键词: Adherence; Alzheimer' s Disease; Attention; Biological Markers; Cellular Phone; Certification; Characteristics; Charge; Clinic; Clinical; Clinical Trials; Cognition; Cognitive; Cognitive Science; Communication; Consultations; Consumption; Data; Data Analyses; Data Set; Development; Distributed Systems; Documentation; Drops; Ensure; Episodic memory; Evaluation; Freezing; Funding; Goals; Gold; Good Clinical Practice; Grant; Home environment; Industry; Inherited; Institution; Learning; Linguistics; Maintenance; Manuscripts; Measurement; Measures; Memory; Methodology; Methods; Mission; Modification; Neuropsychology; Online Systems; Participant; Personal Computers; Pilot Projects; Population; Preparation; Procedures; Process; Protocols documentation; Psychometrics; Quality Control; Registries; Reproducibility; Research; Research Personnel; Running; Semantics; Site; System; Technology; Testing; Time; Training; Translations; Validation; Work; base; cognitive change; cognitive process; cognitive testing; computerized; forgetting; implicit memory; improved; insight; instrument; novel; pre-clinical; processing speed; smartphone Application; standard measure; web-based assessment

Core H: Cognition SUMMARY The Cognition Core of the Dominantly Inherited Alzheimer Network (DIAN) is a newly formed core that will serve the overall grant by overseeing rater training and maintaining rigorous quality control (QC) and documentation standards that ensure the fidelity of longitudinal cognitive assessments. A primary goal of the core is to revise the cognitive assessment battery to align with scientific aims and minimize participant burden. We will remove burdensome and insensitive measures and incorporate novel measures and novel assessment methodologies that are more sensitive to early cognitive changes. These methodologies will improve reliability in measurement of the key features of autosomal dominant Alzheimer disease (ADAD). The assessment of cognition is central for achieving the scientific aims of all DIAN Projects and Cores. The Cognition Core will work with the Project and Core leaders to ensure that fully validated cognitive data is available for DIAN data freezes and provide guidance on appropriate cognitive measures and data analyses to support project and core aims. Due to the unique value of the ADAD population, there is great enthusiasm from DIAN investigators and external investigators to add novel cognitive measures to DIAN. However, any revisions or additions to the battery can be extraordinarily complicated in a global study like DIAN. The Cognition Core has formed an advisory board including leaders in clinical neuropsychology and cognitive psychology from academic institutions and industry who have specific expertise in global AD studies, clinical trials, computerized assessment, and remote technologies. In consultation with the advisory board, the Cognition Core has developed a formalized process for evaluating, piloting, and integrating new cognitive measures. This process involves scrutiny of preliminary data, test characteristics, availability of translations and suitability for remote test administration. A goal of the DIAN renewal is to harmonize DIAN across all affiliated studies to maximize the power of this remarkable dataset for insights into the essential characteristics of ADAD and to support more effective clinical trials. A dedicated Cognition Core serves this mission directly by creating multiple efficiencies across DIAN, the DIAN-Trials Unit (DIAN-TU) and the DIAN Expanded Registry (DIAN EXR). Core measures of the cognitive assessment battery in DIAN formed the basis for the DIAN-TU battery, but there remain crucial differences in the assessments collected, differences in rater training and certification, differences in QC processes, and DIAN only recently has implemented a rigorous system of documentation. A dedicated core will align these procedures, improve QC processes, and facilitate communications between sites and the DIAN Coordinating Center, thus achieving a critical aim of the core: to improve the rigor and reproducibility of cognitive data collected across all DIAN studies.

核心H：认知总结 显性遗传阿尔茨海默病网络（DIAN）的认知核心是一个新形成的核心， 通过监督评分员培训和保持严格的质量控制（QC）来服务于整体赠款， 确保纵向认知评估准确性的文件标准。的主要目标 核心是修订认知评估组合，使其符合科学目标，并尽量减少参与者的负担。 我们将取消繁琐和不敏感的措施，并纳入新的措施和新的评估 对早期认知变化更敏感的方法。这些方法将提高可靠性 常染色体显性阿尔茨海默病（ADAD）的主要特征的测量。评估 认知是实现所有DIAN项目和核心科学目标的核心。认知核心将 与项目和核心领导人合作，确保充分验证的认知数据可用于DIAN数据 冻结并指导适当的认知措施和数据分析，以支持项目， 核心目标。 由于ADAD人群的独特价值，DIAN调查人员对此抱有极大的热情， 外部研究者在DIAN中添加新的认知测量。但是，对 在像DIAN这样的全球研究中，电池可能非常复杂。认知核心已经形成了一个 顾问委员会包括来自学术界的临床神经心理学和认知心理学领导者 在全球AD研究、临床试验、计算机化 评估和远程技术。在咨询委员会的意见后，认知核心已经 开发了一个正式的过程，用于评估，试点和整合新的认知措施。这个过程 包括审查初步数据、测试特性、翻译的可用性和远程应用的适用性。 试验管理。 DIAN更新的目标是协调所有附属研究的DIAN，以最大限度地发挥其作用 一个卓越的数据集，用于深入了解ADAD的基本特征，并支持更有效的临床治疗。 审判专门的认知核心通过在DIAN中创造多种效率，直接服务于这一使命， DIAN试验单位（DIAN-TU）和DIAN扩展登记研究（DIAN EXR）。认知的核心措施 DIAN中的评估组合构成了DIAN-TU组合的基础，但在 收集的评估、评估员培训和认证的差异、QC流程的差异，以及 直到最近，国家税务局才实施了严格的文件系统。一个专门的核心将使这些 程序，改进质量控制流程，并促进研究中心与DIAN协调部门之间的沟通 中心，从而实现了一个关键的核心目的：提高认知数据的严谨性和可重复性 在所有DIAN研究中收集。